Clopidogrel

Clopidogrel is used to reduce atherosclerotic events (myocardial infarction, stroke, vascular deaths) in patients with atherosclerosis documented by recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Clopidogrel is an anti-platelet drug which prevents the clotting of blood in the blood vessels. People with heart problems or a blood vessel disorder can reduce their chances of suffering from heart attack or stroke by taking this medicine everyday.

This medicine is also helpful in prevention of thrombotic complications after coronary stenting. To make sure this medicine is safe for you, inform your doctor if you have any of the following conditions :

• Pregnant or breast-feeding.
• A bleeding disorder, liver or kidney problems or an allergic reaction to a medicine.
• Have recently had surgery or an injury.
• Are taking any other medicines like escitalopram, fluconazole, non-steroidal anti inflammatory drugs and isoniazid.

The usual dose prescribed for this tablet is 75mg. Skip your missed dose if you do not remember until more than 12 hours of the missed dose. Try to keep regular appointments with your doctor.

Take as directed. May cause headache or dizziness; use caution when driving or engaging in tasks that require alertness until response to drug is known. Small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may reduce nausea or vomiting.

Mild analgesics may reduce arthralgia or back pain. Report immediately unusual or acute chest pain or respiratory difficulties, skin rash, unresolved diarrhea or gastrointestinal distress, nosebleed, or acute headache.

Clopidogrel may be considered in aspirin-intolerant patients. It has not been as extensively studied as aspirin or even ticlopidine when used in patients with coronary artery disease.

When used instead of aspirin, cost may become an issue. In one study (CAPRIE), small but significantly superior effects of clopidogrel versus aspirin occurred in patients at risk for ischemic events.

For the prevention of thrombotic complications, clopidogrel is similar in efficacy to ticlopidine and is not associated with neutropenia.

Symptoms of acute toxicity include vomiting, prostration, difficulty breathing, and gastrointestinal hemorrhage. Only one case of overdose with clopidogrel has been reported to date, no symptoms were reported with this case and no specific treatments were required.

Based on its pharmacology, platelet transfusions may be an appropriate treatment when attempting to reverse the effects of clopidogrel. After decontamination, treatment is symptomatic and supportive.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Acute Coronary Syndrome

• Ischemic Stroke

• Myocardial Infarction

• Heart Attack And Stroke

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Allergy

• Bleeding Disorders

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Chest Pain

• Edema (Swelling)

• Hypertension

• Headache

• Dizziness

• Depression

• Fatigue

• Pain

• Rash

• Abdominal Pain

• Dyspepsia

• Diarrhoea

• Nausea

• Hemorrhage

• Urinary Tract Infection

• Arthralgia

• Back Pain

• Rhinitis

• Bronchitis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 12 hours.

• What is the onset of action?

  The effect of this medicine can be observed in 2 hours.

• Are there any pregnancy warnings?

  This medicine is recommended in pregnant women only if necessary. The benefits and risks should be discussed with the doctor before receiving this medicine.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  The excretion of this medicine in breast milk is unknown. It is used only if necessary. The benefits and risks should be discussed with the doctor before taking this medicine.

• Does this affect kidney function?

  If you are a kidney patient, you must discuss with your doctor before using it.

• Is it safe to drive while on this medicine?

  Discuss with your doctor before driving.

• Does this affect liver function?

  Do not consume this drug if you suffer from hepatic impairment.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Below is the list of medicines, which contains Clopidogrel as ingredient

• Clopifast 75 MG Tablet

  Mankind Pharmaceuticals Ltd

• Rosuvas Cv 10 Capsule

  Sun Pharmaceutical Industries Ltd

• Clopijoy 75 MG Tablet

  Torrent Pharmaceuticals Ltd

• Clopione 75 MG Tablet

  Wockhardt Ltd

• Delgrel 75 MG Tablet

  Gold Line

• Clopirad 75 MG Tablet

  Indoco Remedies Ltd

• Synplatt 75 MG Capsule

  Fdc Ltd

• Clopiflo 75 MG Tablet

  Cadila Pharmaceuticals Ltd

• Clopigard 75 MG Tablet

  Cipla Ltd

• Clopitab-Cv 20 Capsule

  Lupin Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

The active constituent of this medicine behaves as a prodrug with anticoagulatory properties that is broken down by CYP450 enzymes to its active metabolite that prevents adenosine diphosphate (ADP) from binding to its platelet P2Y12 receptor. This inhibits the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, which in turn inhibits coagulation.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Medicine

  • CYP2C9 inhibitor
  • Anticoagulants or other antiplatelet agents may increase the risk of bleeding.
  • Warfarin metabolism may be decreased due to clopidogrel inhibition of CYP2C9. Hypoprothrombinemic effects may be increased; monitor INR carefully during initiation or withdrawal.

• Interaction with Food

  May be taken without regard to meals.

• Interaction with Disease

  Use with caution in patients who may be at risk of increased bleeding. Consider discontinuing 7 days before elective surgery. Use caution in mixing with other antiplatelet drugs. Use with caution in patients with severe liver disease (experience is limited). Cases of thrombotic thrombocytopenic purpura (usually occurring within the first 2 weeks of therapy) have been reported.

• Ques : What is Clopidogrel?

  Ans : This drug is used to treat heart attack and stroke.

• Ques : How long do I need to use Clopidogrel before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

• Ques : At what frequency do I need to use Clopidogrel?

  Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Clopidogrel empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Clopidogrel?

  Ans : It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Clopidogrel-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/clopidogrel

• Clopidogrel-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 2 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00758

• CLOPIDOGREL Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=CLOPIDOGREL