Comig 500 Tablet

Comig 500 Tablet is a combination medication, primarily prescribed for the treatment and prevention of migraine attacks. This medication is comprized of two drugs, Naproxen and Domperidone, which belongs to the class of a non-steroidal anti-inflammatory drugs and dopamine antagonists, respectively.

On using this medicine some serious side effects may occur that include easy bruising or bleeding, painful swallowing, ringing in the ears, signs of kidney problems, mood changes, unusual tiredness, swelling of the ankles, feet and hands, unexplained stiff neck, unexplained weight gain and vision changes.

To ensure this medicine is safe for you tell your doctor if you have asthma, blood disorders, nasal polyps, liver disease, heart disease, stroke, high blood pressure or throat, stomach or intestinal problems.

Take this medicine by mouth as instructed by your doctor, usually 2 or 3 times in a day. Remember to not lie down for a minimum of 10 minutes after taking it. To prevent stomach upset, take this drug with milk, food or an antacid.

To reduce your risk of side effects, start the medication at the lowest effective dose for a short period of time. Take a higher dosage if needed, after consulting with a doctor.

• Migraine Headache

• Prevention Of Migraine Attacks

• Hypersensitivity

• Dry Mouth

• Indigestion

• Flu-Like Symptoms

• Is It safe with alcohol?

  Taking this medication with alcohol can increase the risk of stomach bleeding caused by naproxen.

• Are there any pregnancy warnings?

  This medication may be unsafe to use during pregnancy.
  Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Is it safe to drive while on this medicine?

  Do not drive, operate machinery.

• Does this affect kidney function?

  This medicine should not be given in renal failure.
  Caution should be used in patients with severe renal impairment.

• Does this affect liver function?

  There is no interaction between liver impairment and consuming this drug. So dose alteration is not needed.

Below is the list of medicines, which have the same composition, strength and form as Comig 500 Tablet , and hence can be used as its substitute.

• Macprox DP 500 Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Naxdom 500 Tablet

  Sun Pharmaceutical Industries Ltd

• Napra D 500Mg Tablet

  Intas Pharmaceuticals Ltd

• Naprodom 500Mg Tablet

  Crescent Therapeutics Ltd

• Pandex Tablet

  Mission Research Laboratories Pvt Ltd

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• Are there any missed dose instructions?

  If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

This medication is a combination of Naproxen and Domperidone. This medicine is prescribed for the treatment of migraine attacks. As both the drugs belong to two different classes, namely, NSAIDs (Non-Steroidal Anti Inflammatory Drug) and Dopamine antagonist, respectively, thus it works via dual mechanism

Firstly it inhibits prostaglandin synthesis by non selectively impeding the COX -1 and COX -2 enzymes. This helps in alleviating inflammation, as prostaglandin is a regulator for inflammation in muscles. Secondly, it gets attached to the dopaminergic receptors without causing any release of the chemical dopamine. This, in turn, eases gastric emptying and abate small bowel transit time.

• Ques : What is Comig 500 Tablet used for?

  Ans : Comig 500 Tablet is a medication used to treat migraine. This medication contains domperidone and naproxen as active ingredients. Do not chew or break this medicine, it has to be swallowed as a whole and can be taken with or without food at a fixed time.

• Ques : What are the side effects of Comig 500 Tablet?

  Ans : Comig 500 Tablet has several side effects that can appear because of it’s ingredients which are domperidone and naproxen.

  Some of the side effects are mentioned below;

  1. drowsiness
  2. headache
  3. depression
  4. itching
  5. inability of concentration
  6. swelling of eyes and lips

• Ques : Is Comig 500 Tablet safe during pregnancy?

  Ans : Kindly consult with a doctor or specialist for a recommendation on a particular case.

• Ques : How long do I need to use Comig 500 Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Comig 500 Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : What are the instructions for the storage and disposal of Comig 500 Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Naproxen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/naproxen

• Naproxen- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00788

• Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/domperidone

• Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01184