Contra Kit

A medical termination pack or Contra Kit consists of two medicines Mifepristone and Misoprostol that are used to medically terminate the pregnancy. The kit contains 5 tablets. One tablet of Mifepristone and four tablets of Misoprostol.

It is medically prescribed if you are within 63 days of gestation. Doctors do not opt for this process if you are over 10 weeks pregnant. Mifepristone is a synthetic steroid taken orally with water. It interferes with the Progesterone Secretion that terminates the Pregnancy.

Misoprostol is a Synthetic Prostaglandin that causes the cervix to soften, contract the Uterus and allows the emptying of the uterine contents. It is administered vaginally or orally depending on the patient’s condition.

Misoprostol may be self-administered or administered under a gynaecologist’s supervision so that the patient has access to the health facilities, if necessary. In case of an intrauterine pregnancy, termination by surgery is recommended.

The dosage is 1 tablet of Mifepristone, followed by 4 tablets of Misoprostol after 1-3 days. If abortion fails to occur after the administration of Misoprostol, the second dose of Misoprostol (2 tablets) is administered. In case of an intrauterine pregnancy, termination by surgery is recommended.

• Termination Of Pregnancy

• Ectopic Pregnancy

• Unexplained Vaginal Bleeding

• Chronic Adrenal Failure

• Other Bleeding Disorders

• Heavy Vaginal Bleeding

• Infections

• Unusual Tiredness And Weakness

• Abdominal Pain And Cramps

• Uterine Cramping

• Nausea Or Vomiting

• Headache

• Dizziness

• Pain In The Legs

• Decreased Appetite

• Sleeplessness

• Difficulty In Swallowing

• Loss Of Strength

• Difficulty To Breath

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 7-10 days.

• What is the onset of action?

  Mifepristone starts producing the required effects within 1-2 hours of administration.

• Are there any pregnancy warnings?

  It is advised that Mifepristone is used to terminate a pregnancy that is within 63-70 days. Use of this drug to control elevated blood sugar level should not be done if you are pregnant.

• Is it habit forming?

  It is not habit forming.

• Are there any breast-feeding warnings?

  It is recommended that you do not breastfeed your child if the administration of this drug is highly necessary.

• Is It safe with alcohol?

  Interaction with alcohol is still unknown. Consult your doctor before proceeding

• Is it safe to drive while on this medicine?

  Mifepristone may cause sleepiness. It is advised that you do not drive if you are experiencing this side-effect.

• Does this affect kidney function?

  There is no reported impairment to the kidney functioning.

• Does this affect liver function?

  There is no reported impairment to the liver functioning.

• Are there any missed dose instructions?

  For termination of pregnancy, it is a single dose therapy; it is not possible to miss a dose. If you are taking it for controlling blood sugar level and miss a dose, take it as soon as possible. But do not double dose.

• Are there any overdose instructions?

  If you overdose on Mifepristone, contact your physician right away.

This kit blocks the effect of progesterone by competitively binding to the specific receptors and sensitizing the inner linings of the uterus inducing bleeding and contractions. It also blocks the effect of cortisol at the specific receptors and reducing the effect caused by an excess of this hormone.

Misoprostol taken intravaginally behaves as a prostaglandin E1 analogue and reduces the amount of acid produced in the stomach. It further protects the stomach walls by increasing the production of bicarbonates and mucus. It can cause the smooth muscles of the uterus to contract and the cervix to relax.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

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  There are no known alcohol interactions.

• Interaction with Medicine

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  Mifepristone severely interacts with the following drugs- dexamethasone, erythromycin, hydrocortisone, ketoconazole, simvastatin, pimozide, warfarin and ergotamine.

• Interaction with Disease

  Disease

  Information not available.

• Interaction with Food

  Grapefruit juice

  Avoid the consumption of large quantities of grapefruit juice while taking mifepristone as it can alter the levels of this medicine in the blood.

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  It is recommended that you avoid grapefruit juice while taking this medication. It may modify the effects of the drug.

• Ques : What is Contra Kit?

  Ans : This kit has Mifepristone and Misoprostol as active elements present. It is primarily prescribed as a pregnancy termination kit.

• Ques : What are the Side Effects of Contra Kit?

  Ans : This kit has some commonly reported side effects. Here are some side effects of this kit which are as follows: diarrhoea, stomach pain, vaginal bleeding, pelvic pain and cramping, shortness of breath, allergic skin reaction, swelling of face, etc.

• Ques : What are the instructions for storage and disposal Contra Kit?

  Ans : Store this kit in a cool dry place and keep it in the original pack or container until it is time to take them. Store this medication out of sight and reach of children. Unused medicines should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

• Ques : How long do I need to use Contra Kit before I see improvement of my conditions?

  Ans : This kit takes 1 or 2 days before you see an improvement in your health conditions. It would be ideal if you note, it doesn't mean you will begin to notice such health improvement in a similar time span as different patients.

• Ques : What are the contraindications to Contra Kit?

  Ans : In addition, this kit should not be used if you have the following conditions such as hemorrhagic disorder, hypersensitivity, inherited porphyrias, pregnancy and lactation, suspected ectopic pregnancy, etc.

• Ques : Is Contra Kit safe to use when pregnant?

  Ans : This medication is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

• Ques : Will Contra Kit be more effective if taken in more than the recommended dose?

  Ans : No, taking higher than the recommended dose of this kit can lead to increased chances of side effects such as abdominal pain, indigestion, back pain, excessive vaginal bleeding, emesis, diarrhoea, vomiting, heavy bleeding, anxiety, etc.

• Mifepristone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/mifepristone

• Mifepristone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00834

• Misoprostol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/misoprostol

• Misoprostol- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00929