Corbutyl 65/650 MG Tablet

Corbutyl 65/650 MG Tablet helps in controlling the health conditions like hypertension and angina. Known to be a cardio-selective β1 adrenergic agent, it blocks the action of a few naturally occurring chemicals in the body.

It also helps in the prevention of heart failure and myocardial infarction (MI). The drug should only be taken as per the prescribed dose. It has certain side effects that a patient should be aware of.

This medicine is meant for oral consumption and its dosage may vary from 5 mg to 10 mg and 20 mg in some cases. Patients should inform their doctor about the medication that they are currently taking. This is primarily because some medicines, like that of diabetes interfere with the action of this medication.

Patients should also mention if they suffer from any other health issues like kidney or liver problems, slow heartbeat, diabetes, thyroid, asthma or hardened arteries as consumption of the drug may lead to severe complications in such cases.

It is not recommended for expecting or breastfeeding mothers too. If a patient is taking this medicine, he should avoid driving or drive very carefully as the drug can cause confusion and dizzy spells. Fast movement should also be avoided as it can cause dizziness.

Take exactly as directed. Do not increase, decrease, or adjust dosage without consulting the prescriber. Do not take with antacids and do not use alcohol or OTC medications (eg, cold remedies) without consulting the prescriber.

If diabetic, monitor serum sugars closely (may alter glucose tolerance or mask signs of hypoglycemia). May cause fatigue, dizziness, or postural hypotension; use caution when changing position from lying or sitting to standing, or when driving or climbing stairs until response to medication is known.

May cause alteration in sexual performance (reversible). Report palpitations, unresolved swelling of extremities, difficulty breathing or new cough, unresolved fatigue, unusual weight gain, unresolved constipation, or unusual muscle weakness.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• Hypertension

• Angina Pectoris

• Heart Failure

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• Allergy

  Avoid if you have a known history of allergy to this medication or any other medicines belonging to the group Beta Blockers.

• Cardiogenic Shock

  This medication is not recommended in the patients suffering from cardiogenic shock.

• Heart Block Greater Than First Degree

  This medication is not recommended in the patients having a heart block greater than first degree.

• Sinus Bradycardia

  This medication is not recommended in the patients suffering from Bradycardia.

• Pheochromocytoma

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• Drowsiness

• Insomnia

• Edema (Swelling)

• Depression

• Constipation

• Nausea

• Vomiting

• Stomach Discomfort

• Bronchospasm

• Cold Extremities

• Chest Pain

• Nervousness

• Headache

• Confusion

• Itching

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 12 to 24 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 2 to 4 hours of administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for use during pregnancy unless absolutely necessary.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for use in breastfeeding women unless absolutely necessary.

• Does this affect liver function?

  Caution must be taken while using this medicine in patients with liver disease. Adjustment of dose is required. Clcr <40 mL/minute: Initial: 2.5 mg/day; increase cautiously. Kindly consult your doctor before taking it.

• Does this affect kidney function?

  Caution must be taken while using this medicine in patient with kidney disease. Adjustment of dose might be needed. Kindly consult with your doctor before taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• Missed Dose instructions

  If you miss a dose of this medication, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

This medicine blocks beta receptors sites in the heart, blood vessels, and lungs. This results in inhibition of epinephrine resulting in relaxed blood vessels, thus the pressure is lowered and blood flow to the heart is improved.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Endocrinologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Consumption of alcohol should be avoided while taking this medicine, especially when you start taking the medicine or a change its dosage. Symptoms like headache, dizziness, change in pulse or heart rate should be reported to the doctor.

• Interaction with Lab Test

  False lab test may result due to fluctuation in the level of thyroxine (S), cholesterol (S), glucose; triglycerides, uric acid; HDL.

• Interaction with Medicine

  Concomitant use of the following along with the following medicines must be avoided:

  • CYP2D6 enzyme substrate
  • Clonidine: Hypertensive crisis after or during withdrawal of either agent.
  • Drugs which slow AV conduction (digoxin): Effects may be additive with beta-blockers.
  • Glucagon: Bisoprolol may blunt the hyperglycemic action of glucagon.
  • Insulin: Bisoprolol may mask tachycardia from hypoglycemia.
  • NSAIDs (ibuprofen, indomethacin, naproxen, piroxicam) may reduce the antihypertensive effects of beta-blockers.
  • Salicylates may reduce the antihypertensive effects of beta-blockers.
  • Sulfonylureas: Beta-blockers may alter response to hypoglycemic agents.

• Interaction with Disease

  Asthma

  This medication should not be used in patients suffering from bronchial asthma or any other lung disease. Inform the doctor if you had any history of lung diseases or a family history of lung disease. Dose adjustments or an alternate medicine should be considered based on the clinical condition.

  Bradyarrhythmia/Av Block

  This medication or other beta-blockers are not recommended in the patients with Sinus Bradyarrhythmia or heart block greater than the first degree. Inform the doctor if you have any heart diseases or family history of heart diseases. An alternate medicine should be considered based on the clinical condition.

  Glaucoma

  This medication should be administered with caution in a patients suffering from Glaucoma. It may further lower the pressure in the eye.

• Interaction with Food

  May be administered without regard to meals

• Ques : What is Corbutyl 65/650 MG Tablet?

  Ans : This medication is a cardio-selective B1 adrenergic agent, Bisoprolol blocks the action of a few naturally occurring chemicals in the body, thus helping in the control of health conditions like hypertension and angina.

• Ques : How long do I need to use Corbutyl 65/650 MG Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Corbutyl 65/650 MG Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Corbutyl 65/650 MG Tablet empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Corbutyl 65/650 MG Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Bisoprolol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 12 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/bisoprolol

• Bisoprolol- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 12 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00612

• Bisoprolol 10 mg Film-coated Tablet- EMC [Internet] medicines.org.uk. 2019 [Cited 12 December 2019]. Available from:

  https://www.medicines.org.uk/emc/product/8850/smpc