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Overview

Depakote 500 MG Tablet

Manufacturer :  Sanofi India Ltd
Medicine Composition :  Divalproex
Prescription vs OTC : Prescription by Doctor required

About Depakote 500 MG Tablet

Depakote 500 MG Tablet is an anticonvulsant that is used to control seizures and migraine headaches. Take this medicine at the same time regularly. Do not take this medicine if you have are suffering from impaired liver function.

Take exactly as directed (do not increase dose or frequency or discontinue without consulting prescriber). While using this medication, do not use alcohol and other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or hypnotics) without consulting prescriber.

Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). You may experience drowsiness, dizziness, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea, vomiting, loss of appetite, or dry mouth (small frequent meals, frequent mouth care, chewing gum, or sucking lozenges may help). Wear identification of epileptic status and medications.

Report CNS changes, mentation changes, or changes in cognition; muscle cramping, weakness, tremors, changes in gait; persistent GI symptoms (cramping, constipation, vomiting, anorexia); rash or skin irritations; unusual bruising or bleeding (mouth, urine, stool); worsening of seizure activity, or loss of seizure control.

Symptoms of overdose include dizziness ataxia, drowsiness, nausea, vomiting, tremor, agitation, nystagmus, urinary retention, dysrhythmias, coma, seizures, twitches, respiratory depression, neuromuscular disturbances.

Provide general supportive care. Activated charcoal is effective at binding certain chemicals and this is especially true for carbamazepine; other treatment is supportive/symptomatic.

Treatment consists of inducing emesis or gastric lavage. EKG should also be monitored to detect cardiac dysfunction. Monitor blood pressure, body temperature, pupillary reflexes, bladder function for several days following ingestion.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the uses of Depakote 500 MG Tablet

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the contraindications of Depakote 500 MG Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the side effects of Depakote 500 MG Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    Key highlights of Depakote 500 MG Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for an average of 1 to 2 days.

    • What is the onset of action?

      The peak effect of this medicine can be observed in 2 hours for a delayed release tablet.

    • Are there any pregnancy warnings?

      This medicine is not recommended for pregnant women.

    • Is it habit forming?

      No habit forming tendency has been reported

    • Are there any breast-feeding warnings?

      This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.

    • Is It safe with alcohol?

      It is unsafe to consume alcohol along with this drug.

    • Is it safe to drive while on this medicine?

      This medicine might affect the alertness of the patient, thus driving must be avoided while taking it.

    • Does this affect kidney function?

      This medicine is probably safe to be used in patients with kidney disease. Adjustment of dose is needed.

    • Does this affect liver function?

      This medicine is unsafe to be used in patients with liver disease, thus must be avoided. Kindly consult your doctor before taking it.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the substitutes for Depakote 500 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Depakote 500 MG Tablet , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      If you miss a dose of Depakote 500 MG Tablet, take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    Where is the Depakote 500 MG Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

    How does this medication work?

    This medication belongs to the class anticonvulsants. it works by increasing the levels of the neurotransmitter GABA and inhibits sodium and calcium channels thus it reduces the excitation of the brain cells.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

      What are the interactions of Depakote 500 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
      • Interaction with Lab Test

        Information not available.
      • Interaction with Medicine

        Lamotrigine

        Depakote 500 MG Tablet may increase the concentration of lamotrigine and can cause serious skin reactions. Frequent monitoring of undesired effects like skin rash, seizures, tremors is necessary. Suitable dose adjustments or an alternate medicine should be considered based under the doctor's supervision.

        Imipenem

        Use of these medicines is not recommended as it increases the concentration of Depakote 500 MG Tablet. An alternate medicine should be considered based on the clinical condition under the doctor's supervision.

        Warfarin

        Depakote 500 MG Tablet should be given with caution in patients with warfarin or other anticoagulants as this combination may increase the risk of bleeding. Frequent monitoring of blood cells count and prothrombin time is necessary. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.

        Ethinyl Estradiol

        The desired effect of Depakote 500 MG Tablet will not be observed if taken with oral contraceptives. Inform the doctor if you are receiving either of the medications. Monitoring of behavior changes and seizures are necessary. An alternate medicine should be considered based on the clinical condition of the under the doctor's supervision.

        Metoclopramide

        Use of Depakote 500 MG Tablet with metoclopramide should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.
      • Interaction with Disease

        Depression

        Depakote 500 MG Tablet should be given with caution in the patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Dose adjustments are to be made based on the outcomes in the patient.

        Liver Disease

        Depakote 500 MG Tablet is not recommended in patients with liver injury or a family history of liver injury. This risk is more in children less than 2 years of age. Liver function tests are to be performed before starting the treatment. Discontinue the medicine if any abnormality is identified.
      • Interaction with Food

        Information not available.

      FAQs about Depakote 500 MG Tablet

      • Ques : What is Depakote 500 MG Tablet?

        Ans : Depakote 500 MG Tablet is an anticonvulsant.

      • Ques : What is Depakote 500 MG Tablet used for?

        Ans : It is used to control seizures and migraine headaches.

      • Ques : How long do I need to use Depakote 500 MG Tablet before I see improvement in my condition?

        Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

      • Ques : At what frequency do I need to use Depakote 500 MG Tablet?

        Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

      • Ques : Should I use a Depakote 500 MG Tablet empty stomach, before food or after food?

        Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

      • Ques : What are the instructions for the storage and disposal of Depakote 500 MG Tablet?

        Ans : It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

      • Ques : How long does Depakote 500 MG Tablet take to work?

        Ans : Usually, Depakote 500 MG Tablet starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

      • Ques : What if I don't get better after using Depakote 500 MG Tablet?

        Ans : Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

      • Ques : Does Depakote 500 MG Tablet make you sleepy?

        Ans : Yes, Depakote 500 MG Tablet may make you feel sleepy. Avoid driving or other work that requires mental focus until you know how it affects you.

      • Ques : Does Depakote 500 MG Tablet cause hair loss?

        Ans : Yes, Depakote 500 MG Tablet may cause hair loss. However, it is only for a short time and is usually dose related.

      References

      • Divalproex-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/divalproex

      • Divalproex-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 25 May 2022].Available from:

        https://go.drugbank.com/drugs/DB00313

      • Divalproex Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=divalproex

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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