Diloxanide

Diloxanide, an antiprotozoal agent, is the most effective medicine for the patients suffering from amoeba infections (mainly caused by Entamoeba histolytica). As far as health issues are concerned, this is one of the safest medicines.

Recommended dosage is 500mg three times a day for 10 days and the course may be repeated if needed. However excess dosage should be avoided. The mechanism of action of this medicine is, however, unknown. But, as it is a luminal amoebicide it is assumed to work by destroying the trophozoites of Entamoeba histolytica which then form into cysts and the cysts are then excreted out of the body.

The structure of this medication can be related to chloramphenicol as it acts by blocking protein synthesis. The furoate salt of this drug behaves as a prodrug which is metabolized in the gastrointestinal tract to produce diloxanide, the active drug. About 90% of each dose is excreted by urine and the rest through feces.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Parasitic Infections

• Amebiasis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Allergy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Nausea

• Headache

• Abdominal Pain

• Abnormal Liver Function Tests

• Fever

• Dizziness

• Flatulence

• Urticaria

• Pruritus

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  This medication may be unsafe to use during pregnancy.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Does this affect kidney function?

  There is no data available. Please consult a doctor before consuming the drug.

• Does this affect liver function?

  There is no data available. Please consult a doctor before consuming the drug.

• What is the onset of action?

  The pharmacological action is initiated within 30 - 60 minutes after the administration of this medicine.

• How long is the duration of effect?

  This medicine will remain active for about 4 - 5 hrs after its administration.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• Are there any missed dose instructions?

  If you miss a dose of this medication, please consult your doctor.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Below is the list of medicines, which contains Diloxanide as ingredient

• Protobid Plus Tablet

  Iatros Pharmaceuticals Pvt Ltd

• Dilotin Mps 250 Mg/300 Mg/25 Mg Syrup

  Bombay Tablet Mfg Co Pvt Ltd

• Sprot Plus 100 Mg/125 Mg/50 Mg Suspension

  Mapra Laboratories Pvt Ltd

• Sprot Plus 400 Mg/500 Mg/100 Mg Tablet

  Mapra Laboratories Pvt Ltd

• Enterozol Tablet

  Union Drug

• Aristogyl Plus Tablet

  Aristo Pharmaceuticals Pvt Ltd

• Dilotin Mps 250 Mg/300 Mg/25 Mg Tablet

  Bombay Tablet Mfg Co Pvt Ltd

• Metroquin 300 Mg/200 Mg Tablet

  Noel Pharma India Pvt Ltd

• Amirid Tablet

  Menidine Pharmaceuticals

• Amodil 250 Mg/300 Mg/25 Mg Tablet

  Amogh Pharmaceuticals Pvt Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

This medicine used in treating protozoal infections like those by Entamoeba histolytica. It is a luminal amebicide that works by destroying trophozoites of the protozoa. Although the exact mechanism of action is still not clear, it is supposed to work by inhibiting protein synthesis.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Ques : What is Diloxanide?

  Ans : This medication an antiprotozoal agent, is the most effective medicine and very much safe as far as health issue is concerned

• Ques : How long do I need to use Diloxanide before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Diloxanide?

  Ans : The recommended dosage is 500 mg three times a day for 10 days and the course may be repeated if needed.

• Ques : Should I use Diloxanide empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Diloxanide?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Diloxanide- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 10 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/diloxanide

• Diloxanide- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 10 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB08792

• Diloxanide- WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition [Internet]. apps.who.int 1995 [Cited 10 December 2019]. Available from:

  https://apps.who.int/medicinedocs/en/d/Jh2922e/2.1.2.html