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Overview

Diphenoxylate

Prescription vs OTC : Prescription by Doctor required

About Diphenoxylate

Diphenoxylate helps in treating diarrhea. It should not be used in patients with dysentery (diarrhoea with blood). It is advised to drink plenty of liquids as it helps in keeping you hydrated. Also, you are advised to stop taking this medication as soon as your symptoms are relieved.

You must take medical help if your diarrhoea lasts for more than 48 hours. Do not consume this if you have blood in your stool or if you are severely constipated. Use caution while driving or doing anything that requires concentration as this drug can cause dizziness and sleepiness.

Use Diphenoxylate with caution in patients with ulcerative colitis, dehydration, and hepatic dysfunction. High doses of Diphenoxylate may cause physical and psychological dependence with prolonged use.

If chronic diarrhoea is not improved symptomatically within 10 days at a maximum dosage of 20 mg/day, control is unlikely with further use. Symptoms of overdose of Diphenoxylate include drowsiness, hypotension, blurred vision, flushing, dry mouth, miosis.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    What are the uses of Diphenoxylate

    • Severe Diarrhea

    • Loose Stools

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    What are the contraindications of Diphenoxylate ?

    • Hypersensitivity

    • Jaundice

    • Narrow Angle Glaucoma

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    What are the side effects of Diphenoxylate ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    Key highlights of Diphenoxylate

    • Are there any pregnancy warnings?

      Pregnant women are advised to consult a doctor before consuming this drug.

    • Are there any breast-feeding warnings?

      Lactating mothers are advised to take medical help before consuming this medication.

    • Is it habit forming?

      No, the medicine is not habit-forming or addictive.

    • Does this affect kidney function?

      As relevant information is not available, kindly consult your doctor to know if any dose adjustment is needed in patients suffering from kidney diseases.

    • Does this affect liver function?

      Relevant information is not available. Please consult to know if any dose adjustment is needed in patients with liver impairment.

    • How long is the duration of effect?

      The drug will remain active for about 3 - 4 hours afters its onset of action.

    • What is the onset of action?

      The effect of this drug is initiated within 45 - 60 minutes after its administration.

    • Is it safe to drive while on this medicine?

      It is advisable that you do not indulge in driving while on this medication.

    • Is It safe with alcohol?

      Additive CNS effects, avoid use

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    What are the dosage instructions?

    • Are there any overdose instructions?

      In case of an overdose, you may take medical help immediately.

    • Are there any missed dose instructions?

      It is advisable that you do not miss a dosage since there is just one dose per day. Consume the missed dosage as soon as you remember.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    Where is the Diphenoxylate approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    Medicines containing Diphenoxylate

    Below is the list of medicines, which contains Diphenoxylate as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

    How does this medication work?

    Diphenoxylate is an antidiarrheal medication. It works by slowing down the contraction of the intestines thereby decreasing the speed at which the contents pass through it. This allows more time for reabsorption of fluids and nutrients, making the stools more solid and less frequent.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

      What are the interactions of Diphenoxylate ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Using alcohol while taking this drug is not recommended. Any activity requiring a high level of mental alertness should be avoided in such cases.
      • Interaction with Medicine

        Increased toxicity: MAO inhibitors (hypertensive crisis), CNS depressants, antimuscarinics (paralytic ileus); may prolong half-life of drugs metabolized in liver
      • Interaction with Food

        Information not available.

      FAQs about Diphenoxylate

      • Ques : What is the half-life of Diphenoxylate?

        Ans : The half-life of Diphenoxylate is between 12-14 hours.

      • Ques : Is Diphenoxylate safe for pediatrics?

        Ans : The safety and efficacy of Diphenoxylate are not established for children below the age of 2, hence, it is not considered safe for children below the age of 2.

      • Ques : Is Diphenoxylate safe for use in infectious diarrhea?

        Ans : Diphenoxylate is not prescribed to patients suffering from infectious bacteria as it may worsen the symptoms, it is recommended to seek medical help in case of bloody stool and pus.

      • Ques : What are the precautions to take with Diphenoxylate?

        Ans : Diphenoxylate causes dehydration, therefore, it is important to stay well hydrated on this medication.

      • Ques : Does Diphenoxylate cause Ulcerative colitis?

        Ans : Diphenoxylate is not prescribed to patients suffering from Ulcerative colitis as it may worsen the symptoms.

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Content Details
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Anil MehtaMBBS, DNB (General Medicine)General Physician
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