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Overview

DUOFLO COMBIPACK

Manufacturer :  Cipla Ltd
Medicine Composition :  Tamsulosin, Solifenacin
Prescription vs OTC : Prescription by Doctor required

About DUOFLO COMBIPACK

DUOFLO COMBIPACK, is an alpha blocker that helps to relax the enlarged muscles of an affected prostrate and bladder. It helps to ease out the symptoms of benign prostatic hyperplasia (BPH) which includes difficulty in urination, increased need to urinate at odd times, and a weak stream.

Being a medicine for men, DUOFLO COMBIPACK is not for use for women and children. It is important that you brief the doctor about all other medication you’re currently on, as it may lead to adverse reactions with similar medicines such as prazosin, silodosin, etc. Side effects include a drop in blood pressure that may lead to dizziness or fainting.

DUOFLO COMBIPACK is not to be taken if you are allergic to it. Let your doctor know if you have:

DUOFLO COMBIPACK is taken orally, with the dosage depending on your medical condition and response to the treatment. It is important that you take the capsule at the same time every day, thirty minutes after your meal, daily. Taking it regularly would help to increase its effectiveness.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    What are the uses of DUOFLO COMBIPACK

    • Benign Prostatic Hyperplasia

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    What are the contraindications of DUOFLO COMBIPACK ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    What are the side effects of DUOFLO COMBIPACK ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    Key highlights of DUOFLO COMBIPACK

    • Is It safe with alcohol?

      Taking DUOFLO COMBIPACK with alcohol may lower your blood pressure. This can cause dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position.

    • Are there any pregnancy warnings?

      DUOFLO COMBIPACK is highly unsafe to use during pregnancy.
      Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

    • Are there any breast-feeding warnings?

      Unknown. Human and animal studies are not available. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      It may cause dizziness. Exercise caution if you have to drive or operate a machinery.

    • Does this affect kidney function?

      No dose adjustment is needed for patients with the mild to moderate renal disease. Not advisable in patients with the severe renal disease.

    • Does this affect liver function?

      No dose adjustment is needed for patients with the mild to moderate liver disease. Not advisable in patients with the severe liver disease.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

    How does this medication work?

    This medication behaves as an antagonist to alpha-1A as well as alpha-1B-adrenoceptors within the prostatic urethra, bladder neck, prostate and prostatic capsule. Alpha1-adrenoceptors subtypes such as alpha-1A, alpha-1B and alpha-1D.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

      What are the interactions of DUOFLO COMBIPACK ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        • Alpha-adrenergic blockers should not be used in combination with other alpha-adrenergic blocking agents.
        • Warfarin: Use caution with concomitant administration of warfarin and DUOFLO COMBIPACK.
        • Cimetidine resulted in a significant decrease (26%) in the clearance of DUOFLO COMBIPACK which resulted in a moderate increase in DUOFLO COMBIPACK AUC (44%); therefore, use with caution when used in combination with cimetidine (especially doses >0.4 mg).
        • No dosage adjustments necessary if administered with atenolol, enalapril, or Procardia XL®.
      • Interaction with Disease

        Not intended for use as an antihypertensive drug. May cause orthostasis, syncope or dizziness. Patients should avoid situations where injury may occur as a result of syncope. Rule out prostatic carcinoma before beginning therapy with tamsulosin. Anticipate a similar effect if therapy is interrupted for a few days, if dosage is rapidly increased, or if another antihypertensive drug is introduced.

      FAQs about DUOFLO COMBIPACK

      • Ques : What is DUOFLO COMBIPACK?

        Ans : DUOFLO COMBIPACK is an antagonist which performs its action by relaxing the muscle in the bladder. This medication treats symptoms of Benign prostatic hyperplasia and enlargement of the prostate. DUOFLO COMBIPACK is used to increase the flow of urine and also relaxes the bladder muscles. This medication is not recommended to the patients having hypertension and cardiovascular issues.

      • Ques : What are the uses of DUOFLO COMBIPACK?

        Ans : DUOFLO COMBIPACK is an antagonist medication, which is used for the treatment and prevention of conditions such as Benign prostatic hyperplasia and enlargement of the prostate. Apart from these, it can also be used to increase the flow of urine and also relaxes the bladder muscles. This medication is not adequate for patients having hypertension and cardiovascular issues. The patient should inform the doctor about any ongoing medications and treatment before using DUOFLO COMBIPACK to avoid undesirable effects.

      • Ques : What are the Side Effects of DUOFLO COMBIPACK?

        Ans : Side effects include dizziness, lightheadedness, drowsiness, running nose, and allergic reactions. It is a list of possible side-effects that may occur due to the constituting ingredients of this drug.

      • Ques : What are the instructions for storage and disposal DUOFLO COMBIPACK?

        Ans : This drug should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication. It is important to dispose of expired and unused medications properly to avoid adverse effects.

      • Ques : Apart from taking DUOFLO COMBIPACK, what should I do to manage my prostate symptoms?

        Ans : Lifestyle changes can help you manage your symptoms better. Try to urinate when you first get the urge. However, take care not to strain or push to empty your bladder. Avoid drinking fluids (especially alcohol, caffeine) a few hours before bedtime or going out.

      • Ques : When does DUOFLO COMBIPACK start to work?

        Ans : An improvement in urine flow can be seen in 4 to 8 hours after taking this drug. However, it may take 2 to 4 weeks for the full effect to come.

      • Ques : How does DUOFLO COMBIPACK help in the removal of kidney stones?

        Ans : In patients with kidney stones, this medicine helps in the removal of stones via urine. It works by relaxing the muscles of the urinary tract which causes an easy removal of the stones.

      • Ques : Can I take DUOFLO COMBIPACK with vitamin D?

        Ans : Yes, it can be taken with vitamin D. No harmful effects or interactions have been reported when these are used together.

      • Ques : Why should I stop taking DUOFLO COMBIPACK before my cataract surgery?

        Ans : It can cause floppy eye syndrome in which the muscles of the iris become floppy and the pupil constricts unexpectedly during cataract surgery. So, when the eye surgeon actually needs a dilated pupil, it will constrict and restrict the field of surgery and can affect the surgical outcomes.

      • Ques : Why does DUOFLO COMBIPACK cause a stuffy nose?

        Ans : It relaxes the smooth muscles of the blood vessels and this vasodilation of the blood vessels can cause a stuffy nose.

      • Ques : What is the best time to take DUOFLO COMBIPACK?

        Ans : You can take the capsule after breakfast or after the first meal of the day. However, some doctors prefer it to be taken at night time after dinner. You should take it approximately 30 minutes following the same meal every day.

      • Ques : What are the long-term effects of taking DUOFLO COMBIPACK?

        Ans : Usually, it does not cause any side effects in patients with benign enlargement of the prostate gland. However, long-term use of this medication may increase the chances of having infection, rhinitis, pain, and pharyngitis.

      • Ques : Can DUOFLO COMBIPACK cause frequent urination?

        Ans : No, this medication does not cause frequent urination. In fact, this medicine increases the urine flow and decreases the urge to urinate frequently, which is a symptom of benign enlargement of the prostate gland.

      • Ques : Does DUOFLO COMBIPACK cause weight gain?

        Ans : No, this does not usually cause any increase in the weight, even on long-term use.

      References

      • Tamsulosin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 10 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/tamsulosin

      • Tamsulosin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 10 June 2022].Available from:

        https://go.drugbank.com/drugs/DB00706

      • DUTASTERIDE tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 10 June 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=DUTASTERIDE

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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