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Overview

Fluorouracil

Prescription vs OTC : Prescription by Doctor required

About Fluorouracil

Fluorouracil falls under a class of drugs known as anti-metabolites. It is used to treat symptoms of colon and breast, stomach and pancreas cancer. If used topically it treats abnormal skin growth. It functions by prohibiting the growth of cancerous cells.

Before using this medication, notify your doctor if:

  • you are allergic to any ingredient contained within it
  • you have any other allergies
  • you are taking sorivudine
  • you have any serious infection
  • you are taking any prescription or non-prescription drugs
  • you have liver or kidney disorder, you are pregnant, or planning to become pregnant, or are nursing a baby

The dosage should be determined by your doctor based on your condition. The usual dose in adults for treating colon, breast, pancreas, rectum, liver, ovary or stomach cancer is 500 mg by IV infusion for 1-5 days.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the uses of Fluorouracil

    • Breast Cancer

    • Cancer Of Colon And Rectum

    • Skin Lesions

      Topical Use

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the contraindications of Fluorouracil ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the side effects of Fluorouracil ?

    • Nausea

    • Vomiting

    • Weakness

    • Reduced Blood Platelets

    • Increased Risk Of Infection

    • Decreased White Blood Cell Count

    • Bronchospasm

    • Diarrhoea

    • Esophagitis

    • Stomatitis (Inflammation Of The Mouth)

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    Key highlights of Fluorouracil

    • Is It safe with alcohol?

      Interaction with alcohol is unknown. Please consult your doctor.

    • Are there any pregnancy warnings?

      This medication is unsafe to use during pregnancy.

    • Are there any breast-feeding warnings?

      This medication is probably unsafe to use during breastfeeding. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      Caution is advised when driving or operating machinery.

    • Does this affect kidney function?

      There is no data available. Please consult a doctor before consuming the drug.

    • Does this affect liver function?

      There is no data available. Please consult a doctor before consuming the drug.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    What are the dosage instructions?

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    • Are there any missed dose instructions?

      If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    Medicines containing Fluorouracil

    Below is the list of medicines, which contains Fluorouracil as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

    How does this medication work?

    This medication is a chemotherapy drug belonging to the group of antimetabolites. It works by restricting the creation and repairing of DNA cells and thereby prevents the growth and proliferation of the cancer cells in the body.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

      What are the interactions of Fluorouracil ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        This medication interacts with the following medicine which includes inosine, guanosine, guanosine-5'-phosphate, deoxyinosine, thymidine, uridine, cytidine, methotrexate, tamoxifen, interferon, phosphonoacteyl-L-aspartate (PALA), allopurinol, hydroxyurea, dipyridamol and leucovorin.

      FAQs about Fluorouracil

      • Ques : What is Fluorouracil?

        Ans : This medication falls under a class of drugs known as anti-metabolites. It is used to treat symptoms of colon and breast, stomach and pancreas cancer. If used topically it treats abnormal skin growth.

      • Ques : How long do I need to use Fluorouracil before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Fluorouracil?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : Should I use Fluorouracil empty stomach, before food or after food?

        Ans : The dosage should be determined by your doctor based on your condition. The usual dose in adults for treating cancer is 500 mg by IV infusion for 1-5 days.

      • Ques : What are the instructions for the storage and disposal of Fluorouracil?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Fluorouracil-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/fluorouracil

      • Fluorouracil-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 7 June 2022].Available from:

        https://go.drugbank.com/drugs/DB00544

      • FLUOROURACIL injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=FLUOROURACIL

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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