Gardenal 60Mg Tablet

Gardenal 60Mg Tablet alternatively known as phenobarbitone or phenobarbital, it is used in treatment of all types of seizures barring absence seizures. It can also help to treat epilepsy, insomnia and the uncomfortable symptoms of drug withdrawal.

Gardenal 60Mg Tablet works by affecting GABA receptors. The drug facilitates the production of GABA (Gamma Amino Butryic Acid) an amino acid that helps in reducing excitability of neurons. Potential for drug dependency exists, abrupt cessation may precipitate withdrawal, including status epilepticus in epileptic patients.

The drug is contraindicated in patients who have suffered or are suffering from porphyria, hypersensitivity or allergy to barbiturates, respiratory insufficiency, hyperkinesia, liver cell deterioration and other liver problems. It has also been known to cause complications when used with drugs like aceprometazine, adipilon, etc.

Usage of Gardenal 60Mg Tablet can lead to temporary and common side effects like drowsiness, excitation, irritability, loss of balance or coordination, headache, loss of appetite, nausea, vomiting, constipation, etc. depending on the person’s health condition and medical history more severe side effects requiring medical assistance like insomnia, Hypoventilation, apnea, hypotension, syncope can also occur. Therefore, it is very essential to consult a doctor prior to the usage of the drug regarding the dosage to avoid any unwanted and severe side effects.

Symptoms of overdose include unsteady gait, slurred speech, confusion, jaundice, hypothermia, hypotension, respiratory depression, coma. If hypotension occurs, administer I.V. fluids and place the patient in the Trendelenburg position. If unresponsive, an I.V. vasopressor (eg, dopamine, epinephrine) may be required.

Repeated oral doses of activated charcoal significantly reduce the half-life of phenobarbital resulting from an enhancement of nonrenal elimination. The usual dose is 0.1-1 g/kg every 4-6 hours for 3-4 days unless the patient has no bowel movement causing the charcoal to remain in the GI tract.

Assure adequate hydration and renal function. Urinary alkalinization with I.V. sodium bicarbonate also helps to enhance elimination. Hemodialysis or hemoperfusion is of uncertain value. Patients in stage IV coma due to high serum barbiturate levels may require charcoal hemoperfusion.

• Epilepsy

• Seizures

• Allergy

• Porphyria

• Drowsiness

• Skin Rash

• Nausea

• Vomiting

• Vertigo

• Diarrhoea

• Dermatitis

• Constipation

• Respiratory Depression

• Is It safe with alcohol?

  Consult your doctor before consuming alcohol.

• Are there any pregnancy warnings?

  This medicine is unsafe to use during pregnancy. There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.

• Are there any breast-feeding warnings?

  Breastfeeding women must consult doctor before using this medication.

• Is it safe to drive while on this medicine?

  Caution is advised when driving or operating machinery.

• Does this affect kidney function?

  There is no data available. Please consult doctor before consuming the drug.

• Does this affect liver function?

  There is no data available. Please consult doctor before consuming the drug.

• How long is the duration of effect?

  The effect of this medicine will remain for about 6 - 10 hours.

• What is the onset of action?

  The effect of this medicine is initiated within 20 - 60 minutes after its administration.

Below is the list of medicines, which have the same composition, strength and form as Gardenal 60Mg Tablet , and hence can be used as its substitute.

• Phenotone 60Mg Tablet

  Cipla Ltd

• Phenobarb 60Mg Tablet

  Intas Pharmaceuticals Ltd

• Epitan 60Mg Tablet

  Reliance Formulation Pvt Ltd

• Are there any missed dose instructions?

  Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.

• Are there any overdose instructions?

  Consult your doctor in case of overdose.

It is used in the treatment of epilepsy and works by affecting GABA receptors. The drug facilitates the production of GABA (Gamma AminoButyric Acid) an amino acid that helps in reducing excitability of neurons.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Additive CNS effect, avoid use.

• Interaction with Lab Test

  Intake of this medicine may cause flactuation in the serum level of the following - ammonia (B); bilirubin (S), copper (S), assay interference of LDH, LFTs.

• Interaction with Medicine

  • Decreased effect: Gardenal 60Mg Tablet may reduce the efficacy of beta-blockers, chloramphenicol, cimetidine, clozapine, corticosteroids, cyclosporine, disopyramide, doxycycline, ethosuximide, furosemide, griseofulvin, haloperidol, lamotrigine, methadone, nifedipine, oral contraceptives, phenothiazine, phenytoin, propafenone, psychotropics, quinidine, tacrolimus, TCAs, theophylline, warfarin, and verapamil.
  • Increased toxicity when combined with other CNS depressants, benzodiazepines, valproic acid, chloramphenicol, or antidepressants; respiratory and CNS depression may be additive.
  • MAOIs may prolong the effect of Gardenal 60Mg Tablet.
  • Barbiturates stimulate the metabolism of beta-blockers and decrease their serum concentrations; consider a renally-eliminated beta-blocker (atenolol, nadolol).
  • Barbiturates may enhance the hepatotoxic potential of acetaminophen via an increased formation of toxic metabolites.
  • Barbiturates may increase chloramphenicol metabolism and chloramphenicol may inhibit the metabolism of barbiturates.
  • Barbiturates may increase the metabolism of corticosteroids, cyclosporine, disopyramide, griseofulvin, nifedipine, oral contraceptives, phenytoin, propafenone, quinidine, verapamil; dosage adjustments may be useful.
  • Barbiturates may enhance the metabolism of methadone resulting in methadone withdrawal.
  • Felbamate may increase Gardenal 60Mg Tablet concentrations leading to toxicity.
  • Gardenal 60Mg Tablet may reduce the diuretic response to furosemide; monitor.
  • Concurrent use of Gardenal 60Mg Tablet with meperidine may result in increased CNS depression.
  • Concurrent use of Gardenal 60Mg Tablet with primidone may result in elevated Gardenal 60Mg Tablet serum concentrations.
  • Valproic acid inhibits the metabolism of Gardenal 60Mg Tablet resulting in elevated serum phenobarbital concentrations.

• Interaction with Food

  • Protein-deficient diets: Increases duration of action of barbiturates. Should not restrict or delete protein from diet unless discussed with physician. Be consistent with protein intake during therapy with barbiturates.
  • Fresh fruits containing vitamin C: Displaces drug from binding sites, resulting in increased urinary excretion of barbiturate. Educate patients regarding the potential for a decreased anticonvulsant effect of barbiturates with consumption of foods high in vitamin C.
  • Vitamin D: Loss in vitamin D due to malabsorption; increase intake of foods rich in vitamin D. Supplementation of vitamin D may be necessary.

• Interaction with Disease

  Do not administer to patients in acute pain. Use caution in elderly, debilitated, renally or hepatic dysfunction, and pediatric patients. May cause paradoxical responses, including agitation and hyperactivity, particularly in acute pain and pediatric patients. Use with caution in patients with depression or suicidal tendencies, or in patients with a history of drug abuse. Tolerance, psychological and physical dependence may occur with prolonged use. May cause CNS depression, which may impair physical or mental abilities.

• Ques : What is Gardenal 60mg tablet?

  Ans : Gardenal tablet is a medication which has Phenobarbitone as an active factor present in it. This medicine performs its action by works as sedative hypnotic to control seizures. Gardenal tablet is used to treat conditions such as Anticonvulsant, Sedative, Epileptic fits, Convulsion, Agitation, Anaesthesia, etc.

• Ques : What is the use of Gardenal 60mg tablet?

  Ans : Gardenal is used for the treatment and prevention from conditions such as Epileptic seizures, Anxiety, Anticonvulsant, Sedative, and Epileptic fits. Apart from these, it can also be used to treat conditions like Convulsion, Agitation, and Anaesthesia. The patient should inform the doctor about any ongoing medications and treatment before using Gardenal 60 mg tablet to avoid undesirable effects.

• Ques : What are the side effects of Gardenal 60mg tablet?

  Ans : Side effects of this medication are Hangover, Memory problems, Loss of full control of bodily movements, Bruising or bleeding, Arthralgia, Depression, Suicidal thoughts, Sensitivity to light, Reduced thyroid hormones, Vitamin k, Sores on skin or mouth ulcers, Inflammation of tendons, Anemia, Low blood pressure, Lack of energy, Aggression, Problems with concentrating, Lack of coordination or jerky movements, Shedding of skin, Swelling in the glands, Fibromas, Softening of bones, Joint pain, Fever or jaundice, Phosphate or calcium in blood, Mental confusion, Impaired performance, and Rashes.

• Ques : Is it an enzyme inducer?

  Ans : Yes, It is an enzyme inducer.

• Ques : How long do I need to use gardenal 60mg tablet before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 2 weeks. But the same duration is not mandatory for everyone and so, it is not a standard time period for this medication's action. Please consult your doctor, for the time period you need to use this medication.

• Ques : At what frequency do I need to use gardenal 60mg tablet?

  Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use gardenal 60mg tablet empty stomach, before food or after food?

  Ans : This medication is common to be taken orally and the action of salts involved in this medication, do not depend on whether taking it pre-meal or post-meal. It is advised to consult a doctor before use and take it at a fixed time in a day.

• Ques : What are the instructions for the storage and disposal of gardenal 60mg tablet?

  Ans : This medication contains salts which are suitable to store between 20 to 25 c temperature. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, for avoiding its inadequate effect.

• Phenobarbital- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 16 May 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/50-06-6

• Phenobarbital- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 16 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB01174

• PHENOBARBITAL- phenobarbital tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2012 [Cited 16 May 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=894c57ee-0f5f-41a1-9e0d-3f1f8fdfc9ab

• Phenobarbital Accord Tablets BP 60mg- EMC [Internet]. www.medicines.org.uk. 2019 [Cited 16 May 2019]. Available from:

  https://www.medicines.org.uk/emc/product/5844/smpc