Glyceryl Trinitrate

Glyceryl Trinitrate is prescribed for the treatment of angina pectoris. The I.V. is used for congestive heart failure (especially when associated with acute myocardial infarction). It is also helpful in treating pulmonary hypertension.

During hypertensive emergencies occurring perioperatively (especially during cardiovascular surgery), this medication is primarily prescribed to make it go away. Glyceryl Trinitrate is a kind of nitrate also known as Nitroglycerin, it came into medical use in 1878.

It is used to cure heart failure, high blood pressure, relief from chronic anal fissures and control of blood flow during the course of an operation. Glyceryl Trinitrate helps to widen your blood vessels allowing the increasing flow of blood to your heart muscle.

Side effects of using Glyceryl Trinitrate include headaches, dizziness, low blood pressure, nausea, diarrhea, lightheadedness, irregular or fast heartbeat, stomach pain, restlessness, anxiety, sweating. Serious allergic reactions are trouble breathing, skin rashes or swelling.

In case you develop any of the allergic reactions notify your health care provider. Certain precautions that you should ensure before taking this medication include informing you doctor of the following conditions if you have or are:

• Pregnant or are planning to become pregnant.
• Breastfeeding a baby.
• A case of low blood pressure.
• Low levels of blood or low levels of oxygen.
• Glaucoma.
• Allergic to any medicine.
• Recent heart attack.
• Haemorrhoids.
• Migraines or frequent headache problems.
• Liver or a kidney problem.

The dosage for Glyceryl Trinitrate depends on your gender, height, weight, medical history and overall health. Glyceryl Trinitrate should be stored in a cool and dry place, out of the reach of children. It can be stored up to eight weeks after which it is recommended that you get a fresh batch.

Do not change brands without consulting prescriber. Do not discontinue abruptly. Keep medication in original container, tightly closed. Take medication while sitting down and use caution when changing position (rise from sitting or lying position slowly).

Glyceryl Trinitrate may cause dizziness. use this medicine with caution when driving or engaging in hazardous activities until response to drug is known. If chest pain is unresolved in 15 minutes, seek emergency medical help at once. Report acute headache, rapid heartbeat, unusual restlessness or dizziness, muscular weakness, or blurring vision.

Concomitant use of sildenafil (Viagra®) may precipitate acute hypotension, myocardial infarction, or death. Nitrates used in right ventricular infarction may induce acute hypotension. Nitrate use in severe pericardial effusion may reduce cardiac filling pressure and precipitate cardiac tamponade.

In the management of heart failure, the combination of isosorbide dinitrate and hydralazine confers beneficial effects on disease progression and cardiac outcomes.

May need to use nitrate-free interval (10-12 hours/day) to avoid tolerance development; gradually decrease dose in patients receiving NTG for prolonged period to avoid withdrawal reaction.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Angina Pectoris

• Hypertension During Surgeries

• Chronic Anal Fissures

• Congestive Heart Failure

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Allergy

• Anemia

• Glaucoma

• Obstructive Heart Disease

• Head Trauma/Increased Intracranial Pressure

• Medicine for erectile dysfunction

• Heparin

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Headache

• Hypotension

• Light Headedness

• Syncope

• Rash

• Dizziness

• Weakness

• Restlessness

• Vertigo

• Palpitations

• Urinary Incontinence

• Blurred Vision

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 12 hours upon oral administration. This time duration is subject to variations depending on the route of administration.

• What is the onset of action?

  The effect of this medicine can be observed within an hour of oral administration. However, this time is subject to vary depending on the route of administration. The effect of this medicine can be observed within minutes of intravenous administration and takes about 30-60 when administered topically.

• Are there any pregnancy warnings?

  The use of this medicine by pregnant women is not recommended unless necessary and the benefits outweigh the risks involved with use. Consult your doctor before using this medicine.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  The use of this medicine is not recommended by breastfeeding women unless necessary. Consult your doctor before using this medicine.

• Is It safe with alcohol?

  It is unsafe to consume alcohol along with this medicine. Kindly consult your doctor before taking it.

• Is it safe to drive while on this medicine?

  This medicine affects the alertness of the patient. Thus driving must be avoided while taking this medicine.

• Does this affect kidney function?

  This medicine is probably safe to be used in patients with kidney disease. Adjustment of dose might not be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Limited information is available regarding its use in patients with liver disease. Kindly consult your doctor before taking it.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Missed Dose instructions

  Contact your doctor immediately if you miss a scheduled dose of this medicine.

• Are there any overdose instructions?

  Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms of an overdose may include headache, confusion, fever, change in the heart beat, nausea, vomiting etc.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Below is the list of medicines, which contains Glyceryl Trinitrate as ingredient

• Angiplat 2.5 MG Capsule

  Micro Labs Ltd

• Nitract 2.5 MG Capsule SR

  Astrazeneca Pharma India Ltd

• Vasovin Xl 6.5 MG Capsule XL

  Torrent Pharmaceuticals Ltd

• G3N 6.4 MG Tablet

  Emcure Pharmaceuticals Ltd

• Nitrogard 2.6 MG Tablet

  Cipla Ltd

• Angispan 2.5 MG Capsule TR

  Usv Ltd

• Nitroject 50 MG Injection

  Sun Pharma Laboratories Ltd

• Nitroglyn 50 MG Injection

  United Biotech (P) Ltd

• Angistat 2.5 MG Tablet

  Ranbaxy Laboratories Ltd

• Vasovin Xl 2.5 MG Capsule XL

  Torrent Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

This medication works by getting converted to nitric oxide (NO) free radicals in the body which relax the blood vessels and reduces the load on the heart. This results in improved blood flow and reduced oxygen demand.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Avoid the use of alcohol while taking this medicine.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  • Alteplase (tissue plasminogen activator) has a lesser effect when used with I.V. nitroglycerin; avoid concurrent use.
  • Ergot alkaloids may cause an increase in blood pressure and decrease in antianginal effects; avoid concurrent use.
  • Heparin's effect may be reduced by I.V. nitroglycerin. May affect only a minority of patients.
  • Sildenafil potentiates the hypotensive effects of nitrates; concurrent use is contraindicated.

• Interaction with Food

  Information not available.

• Interaction with Disease

  Severe hypotension can occur. Use with caution in volume depletion, hypotension, and right ventricular infarctions. Paradoxical bradycardia and increased angina pectoris can accompany hypotension. Orthostatic hypotension can also occur. Alcohol can accentuate this. Tolerance does develop to nitrates and appropriate dosing is needed to minimize this (drug-free interval). Safety and efficacy have not been established in pediatric patients. Avoid use of long-acting agents in acute MI or CHF; cannot easily reverse. Nitrate may aggravate angina caused by hypertrophic cardiomyopathy.

• Ques : What is Glyceryl Trinitrate?

  Ans : Glyceryl Trinitrate is prescribed for the treatment of angina pectoris. The I.V. is used for congestive heart failure (especially when associated with acute myocardial infarction).

• Ques : What are the uses of Glyceryl Trinitrate?

  Ans : The primary use of this medication is as Angina Pectoris, Hypertension During Surgeries, Chronic Anal Fissures and Congestive Heart Failure.

• Ques : What are the side effects of this Glyceryl Trinitrate?

  Ans : Side effects of using Glyceryl Trinitrate include headaches, dizziness, low blood pressure, nausea, diarrhea, lightheadedness, irregular or fast heartbeat, stomach pain, restlessness, anxiety, sweating.

• Ques : How long do I need to use Glyceryl Trinitrate before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : What is the mode of action of this Glyceryl Trinitrate?

  Ans : This medication works by getting converted to nitric oxide (NO) free radicals in the body which relax the blood vessels and reduces the load on the heart.

• Ques : At what frequency do I need to use Glyceryl Trinitrate?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Glyceryl Trinitrate empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Glyceryl Trinitrate?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : How is this Glyceryl Trinitrate administered?

  Ans : This medication is administered intravenously.

• Nitroglycerin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 4 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/nitroglycerin

• Nitroglycerin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 4 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00727

• NITROGLYCERIN solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 4 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=NITROGLYCERIN