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Overview

Grafmet 500 MG Injection

Manufacturer :  Panacea Biotec Ltd
Medicine Composition :  Methyl Prednisolone
Prescription vs OTC : Prescription by Doctor required

About Grafmet 500 MG Injection

Grafmet 500 MG Injection is a steroid, which prevents the release of certain chemicals in the body that result in inflammation. The drug is quite effective in the treatment of a number of inflammatory health problems such as gland disorders, lupus, arthritis, psoriasis as well as ulcerative colitis. It also treats various other inflammatory conditions of the lungs, skin, eyes, blood cells, stomach and nervous system of the body.

Because the steroid is strong it can lead to a number of side effects which gradually disappear as the body adjusts to the medicine. Some of these side effects are weakness and slight muscle pain, headache, bloating and discomfort of the stomach. Make sure to contact your doctor if you experience the following-

  • Tunnel or blurred vision along with eye pain
  • problems with breathing
  • behavioral changes, mood swing and depression
  • pain in the arms back or leg
  • convulsions
  • Before you start the medicine the doctor needs to ensure if Grafmet 500 MG Injection is safe. Thus make sure to provide him a detailed history of your allergies, overall fitness and existing health problems. Inform him if you suffer from problems like hypertension, heart disease, kidney or liver issues, tuberculosis, pinworms, thyroid disorders, mental illness, epilepsy or cataracts. Depending on your health the doctor will then adjust the dosage of Grafmet 500 MG Injection.

    The dosage of Grafmet 500 MG Injection for adults may vary from 4mg to 48mg daily. In case of children dosage is decided depending upon the health of the patient and condition that is being treated.

    Certain precautions should also be taken to prevent side effects from aggravating. For instance avoid grapefruit juice consumption. it is also advised that ‘live’ vaccines should not be taken when on this drug. Patients taking Grafmet 500 MG Injection can easily catch infections. Thus they should also avoid interacting with sick family members or friends.

    What are the uses of Grafmet 500 MG Injection

    • Acute Gout

      Grafmet 500 MG Injection is useful in treating Gout which is a type of joint inflammation. Sudden pain at night time and redness of the joints are few symptoms of Gout.

    • Psoriasis

      Grafmet 500 MG Injection is used to cure Psoriasis which is a type of skin disease. Itchy or sore patches and red skin are few symptoms of Psoriasis.

    • Nephrotic Syndrome

      Grafmet 500 MG Injection helps against Nephrotic syndrome which is a type of kidney disease. Swelling of face, skin rash are few symptoms of this condition.

    • Rheumatoid Arthritis

      Grafmet 500 MG Injection is helpful in treating Rheumatoid Arthritis (symptoms include swelling, pain, and stiffness of joints).

    • Asthma

      Grafmet 500 MG Injection is used in the treatment of Asthma which is an inflammation of the airways. Wheezing, cough and difficulty in breathing are few symptoms of Asthma.

    What are the contraindications of Grafmet 500 MG Injection ?

    • Allergy

      Avoid taking this medicine if you are allergic to it or any other glucocorticoids.

    • Fungal Infections

      Avoid taking this medicine in patients suffering from systemic fungal infections.

    • Idiopathic Thrombocytopenic Purpura

      Intramuscular injection of Grafmet 500 MG Injection is not recommended in the patients suffering from this condition.

    What are the side effects of Grafmet 500 MG Injection ?

    • Aggression Or Anger

    • Decreased Urine Output

    • Dizziness

    • Headache

    • Difficulty In Breathing

    • Change In Mood

    • Increased Appetite

    Key highlights of Grafmet 500 MG Injection

    • How long is the duration of effect?

      The effect of this medicine lasts for a duration of 1-4 weeks after an intramuscular injection.

    • What is the onset of action?

      The peak effect of this medicine is observed within 30 minutes of an intravenous injection.

    • Are there any pregnancy warnings?

      This medicine is recommended for pregnant women only if clearly needed and if no other safer alternative is available.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is known to excreted through breast milk in small amounts. Use this medicine only if clearly needed when no other safer alternative is available.

    What are the substitutes for Grafmet 500 MG Injection ?

    Below is the list of medicines, which have the same composition, strength and form as Grafmet 500 MG Injection , and hence can be used as its substitute.

    What are the dosage instructions?

    • Missed Dose instructions

      The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    How does this medication work?

    Grafmet 500 MG Injection belongs to Glucocorticoids class of drugs. It works by binding to the receptor and inhibits the release of inflammatory substances thus helps in the treatment of inflammation or allergic disorders.

      What are the interactions of Grafmet 500 MG Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Lab

        Information not available.
      • Interaction with Medicine

        Ethinyl Estradiol

        Use with caution as this combination will increase the concentration of Grafmet 500 MG Injection. Inform the doctor if you are taking either of the medicines. Consider an alternative medicine or dose adjustments after consulting your doctor.

        Azole antifungal agents

        Use of ketoconazole and itraconazole should be avoided as these medicines may increase the concentration of Grafmet 500 MG Injection in the body which may cause swelling, high blood glucose, weight gain, and growth abnormalities in the children. Dose adjustments or an alternative medicine should be considered based on the clinical condition.

        Antihypertensives

        Use with caution as this combination will decrease the concentration of Antihypertensives. This interaction is more likely to occur if Grafmet 500 MG Injection is taken for more than a week. Inform the doctor if you are taking either of the medicines. Consider an alternative medicine or dose adjustments after consulting your doctor.

        Nonsteroidal anti-inflammatory drugs

        Use with caution as this combination will increase the risk of gastrointestinal bleeding. Inform the doctor if you are taking either of the medicines. Consider taking alternative medicine after consulting your doctor.
      • Interaction with Disease

        Gastrointestinal Bleeding

        Grafmet 500 MG Injection is used with caution in the patients with gastrointestinal diseases. The risk of bleeding is more when taken for a long duration of time. Dose adjustments are to be made based on the clinical condition.

        Diabetes

        Grafmet 500 MG Injection is used with caution in the patients with diabetes as it increases the blood glucose levels. Regular monitoring of blood glucose levels is necessary. A suitable antidiabetic agent is prescribed based on the clinical condition.
      • Interaction with Food

        Grapefruit juice

        Consumption of grapefruit juice is not recommended when you are taking Grafmet 500 MG Injection. Inform the doctor if you experience any undesired effects.
      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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