Grandem 1mg/ml Injection

Grandem 1mg/ml Injection is used as the prophylaxis and treatment of chemotherapy-related emesis; may be prescribed for patients who are refractory to or have severe adverse reactions to standard antiemetic therapy.

This medicine may be prescribed for young patients (ie, <45 years of age who are more likely to develop extrapyramidal reactions to high-dose metoclopramide) who are to receive highly emetogenic chemotherapeutic agents.

Grandem 1mg/ml Injection should not be prescribed for chemotherapeutic agents with a low emetogenic potential (eg, bleomycin, busulfan, cyclophosphamide <1000 mg, etoposide, 5-fluorouracil, vinblastine, vincristine).

Grandem 1mg/ml Injection, a 5-HT3 receptor antagonist, is used for preventing vomiting and nausea caused by cancer chemotherapy. It works by blocking serotonin in the body that can cause vomiting.

Do not use Grandem 1mg/ml Injection if you are allergic to it or if you are taking apomorphine. Some medical conditions that may interfere with the action of this medicine are heart problems, blood electrolyte problems, an abnormal electrocardiogram and stomach or bowel problems.

Common side effects of this medicine are anxiety, constipation, trouble sleeping, diarrhoea, headache, dizziness, drowsiness, nausea, vomiting and weakness. Some serious side effects include severe allergic reactions, fast or irregular heartbeat, chest pain, fainting, fever, chills, stomach pain or swelling, sore throat, severe or persistent skin irritation and unusual muscle movement.

This drug is taken orally before 24 hours of a surgery or chemotherapy. It can also be taken into a vein as directed by your doctor, usually 30 minutes before cancer chemotherapy or surgery. The drug may be directly administered into a vein in 30 seconds, or it may be mixed with IV fluid and administered into a vein in 5 minutes.

This drug will be administered on days when you receive chemotherapy to reduce nausea and vomiting. If outpatient chemotherapy, you may be given oral medication to take after return home; take as directed.

You may experience drowsiness; use caution when driving. For persistent acute headache request analgesic from prescriber. Frequent mouth care, chewing gum, or sucking on lozenges may relieve persistent nausea. Report unrelieved headache, fever, diarrhea, or constipation.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Nausea

• Vomiting

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Headache

• Dizziness

• Insomnia

• Anxiety

• Constipation

• Abdominal Pain

• Diarrhoea

• Weakness

• Arrhythmia

• Agitation

• Hot Flashes

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  Grandem 1mg/ml Injection is probably safe to use during pregnancy. Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

• Are there any breast-feeding warnings?

  Grandem 1mg/ml Injection is probably safe to use during breastfeeding. Please consult your doctor.

• Is it safe to drive while on this medicine?

  There is no interaction between driving and consuming this drug. So dose alteration is not needed.

• Does this affect kidney function?

  There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

• Does this affect liver function?

  Kinetic studies in patients with hepatic impairment showed that total clearance was approximately halved, however, standard doses were very well tolerated. Please consult doctor before consuming the drug.

• How long is the duration of effect?

  The effects generally last no more than 24 hours maximum.

• What is the onset of action?

  This medicine commonly controls emesis within 1-3 minutes of administration.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Are there any missed dose instructions?

  If you miss a dose of Grandem 1mg/ml Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Grandem 1mg/ml Injection is an antiemetic agent working as a selective antagonist of 5-HT3 serotonin receptors centrally as well as peripherally. Inhibition of 5-HT3 receptors directly as well as indirectly inhibits the visceral stimulation of the vomiting center in turn.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Concomitant use of Grandem 1mg/ml Injection along with bleomycin, busulfan, cyclophosphamide <1000 mg, etoposide, 5-fluorouracil, vinblastine, vincristine must be avoided.

• Interaction with Disease

  Use with caution in patients with liver disease or in pregnant patients.

• Ques : What is Grandem 1mg/ml Injection used for?

  Ans : Grandem 1mg/ml Injection is an antiemetic medicine used to treat and prevent nausea or vomiting caused after any surgical procedure or due to certain medicines, stomach upset, or cancer treatment. It also prevents nausea due to motion sickness to some extent.

• Ques : What are the side effects of Grandem 1mg/ml Injection?

  Ans : The most common side effects of Grandem 1mg/ml Injection are sleepiness, weakness, headache, constipation and diarrhea. However, these are not usually bothersome and resolve in some time on their own. Consult your doctor, if the symptoms worry you or persist for a longer duration. Your doctor will suggest ways to cope up with these side effects and to prevent them in future.

• Ques : Is Grandem 1mg/ml Injection safe to be used in pregnant women?

  Ans : Grandem 1mg/ml Injection did not show any adverse effects in research studies done on animals. However, since the safety and efficiency of Grandem 1mg/ml Injection in pregnant women is unknown. It is not recommended to be used in women who are pregnant women or if you are planning to conceive unless prescribed by your doctor.

• Ques : Is Grandem 1mg/ml Injection better than Ondansetron?

  Ans : Grandem 1mg/ml Injection and Ondansetron belong to the same class of medicines, that is serotonin 5-HT3 receptor antagonists. Both these medicines help prevent nausea and vomiting effectively. Grandem 1mg/ml Injection is comparatively well tolerated, quicker in action and alleviates nausea and vomiting relatively faster.

• Ques : Does Grandem 1mg/ml Injection cause constipation?

  Ans : Yes, Grandem 1mg/ml Injection may cause constipation as one of the common side effects. However, this is usually not bothersome.

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  https://druginfo.nlm.nih.gov/drugportal/name/granisetron

• Granisetron-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 10 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00889

• GRANISETRON injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 10 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=GRANISETRON