Macprox DP 500 Tablet

Macprox DP 500 Tablet is a combination medication, primarily prescribed for the treatment and prevention of migraine attack. This medication is comprized of two drugs, Naproxen and Domperidone, which belongs to the class of a non-steroidal anti-inflammatory drugs and dopamine antagonists, respectively.

On using this medicine some side effects like stomach upset, nausea, vomiting, heartburn, drowsiness, headache may occur. Serious side effects may include easy bruising or bleeding, painful swallowing, ringing in the ears, signs of kidney problems, mood changes, unusual tiredness, swelling of the ankles, feet and hands, unexplained stiff neck, unexplained weight gain and vision changes.

To ensure this medicine is safe for you tell your doctor if you have asthma, blood disorders, nasal polyps, liver disease, heart disease, stroke, high blood pressure or throat, stomach or intestinal problems.

Take this medicine by mouth as instructed by your doctor, usually 2 or 3 times in a day. Remember to not lie down for a minimum of 10 minutes after taking it. To prevent stomach upset, take this drug with milk, food or an antacid.

To reduce your risk of side effects, start the medication at the lowest effective dose for a short period of time. Take a higher dosage if needed, after consulting with a doctor.

• Prevention Of Migraine Attacks

• Tumor Of Pituitary Gland

• Allergy

• Severe Asthma And Breathing Problems

• Heart Diseases

• Dryness In Mouth

• Flu-Like Symptoms

• Indigestion

• Is It safe with alcohol?

  Taking this medication with alcohol can increase the risk of stomach bleeding.

• Are there any pregnancy warnings?

  This medication is unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Is it safe to drive while on this medicine?

  Do not drive, operate machinery.

• Does this affect kidney function?

  This medication should not be given in renal failure. Caution should be used in patients with severe renal impairment.

• Does this affect liver function?

  There is no interaction between liver impairment and consuming this medication. So dose alteration is not needed.

Below is the list of medicines, which have the same composition, strength and form as Macprox DP 500 Tablet , and hence can be used as its substitute.

• Comig 500 Tablet

  Seagull Pharmaceutical Pvt Ltd

• Naxdom 500 Tablet

  Sun Pharmaceutical Industries Ltd

• Napra D 500Mg Tablet

  Intas Pharmaceuticals Ltd

• Naprodom 500Mg Tablet

  Crescent Therapeutics Ltd

• Pandex Tablet

  Mission Research Laboratories Pvt Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as possible but skip it if almost the time for next scheduled dose.

• Are there any overdose instructions?

  Consult your doctor in case of an overdose of this medication.

This medication is a combination of Naproxen and Domperidone. This medicine is prescribed for the treatment of migraine attacks. As both the drugs belong to two different classes, namely, NSAIDs (Non-Steroidal Anti Inflammatory Drug) and Dopamine antagonist, respectively, thus it works via dual mechanism.

Firstly it inhibits prostaglandin synthesis by non selectively impeding the COX -1 and COX -2 enzymes. This helps in alleviating inflammation, as prostaglandin is a regulator for inflammation in muscles. Secondly, it gets attached to the dopaminergic receptors without causing any release of the chemical dopamine. This, in turn, eases gastric emptying and abate small bowel transit time.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  Alcohol

  Alcohol consumption is not advised when taking this medication as it may increase the risk of stomach bleeding.

• Interaction with Medicine

  Medicine

  Do not use this medication in combination with Cisapride, Erythromycin, Ketoconazole, Ramipril, Tramadol, Warfarin, Ketorolac, Bromocriptine and Prednisolone.

• Interaction with Disease

  Disease

  Patients who suffer from Asthma, kidney/liver/heart disease and Intestinal Disorders should not consume this medication.

• Ques : What is Macprox DP 500 Tablet?

  Ans : This medication has Naproxen and Domperidone as active ingredients present. It performs its action by obstructing the release of cyclooxygenase (chemical messengers) in the brain. Do not chew or break this medicine, it has to be swallowed as a whole and can be taken with or without food at a fixed time.

• Ques : What are the uses of Macprox DP 500 Tablet?

  Ans : This medication is used for the treatment and prevention from conditions and symptoms of MIgraine.

• Ques : What are the Side Effects of Macprox DP 500 Tablet?

  Ans : This is a list of possible side-effects which may occur due to the constituting ingredients of this medication. These include flu, indigestion, mouth dryness, constipation, heart failure, visual disturbances, nausea, and liver dysfunction.

• Ques : What are the instructions for storage and disposal Macprox DP 500 Tablet?

  Ans : This medication should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Naproxen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/naproxen

• Naproxen- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00788

• Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/domperidone

• Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01184