Markzole 150 MG Tablet

Markzole 150 MG Tablet is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.

Markzole 150 MG Tablet is indicated for oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-threatening Candida infections (eg, cystitis, esophagitis); treatment of hepatosplenic candidiasis and other Candida infections in persons unable to tolerate amphotericin B.

It is also prescribed for the treatment of cryptococcal infections; secondary prophylaxis for cryptococcal meningitis in persons with AIDS; antifungal prophylaxis in allogeneic bone marrow transplant recipients.

This medicine belongs to the class of triazole antifungal. Markzole 150 MG Tablet is effectively used in the treatment of meningitis. It affects the membranes in the brain and spinal cord. This drug treats fungal infections like yeast infections in the mouth, throat, food pipe, lungs, vagina, etc.

It works by decreasing the production of ergosterol, which inhibits cell membrane formation in fungi. This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation.

Some serious side effects that may occur and need immediate medical attention are:

• Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage
• Severe rash or peeling of the skin in patients suffering from cancer or AIDS
• Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)

Symptoms of overdose include decreased lacrimation, salivation, respiration and motility, urinary incontinence, cyanosis. Treatment includes supportive measures, a 3-hour hemodialysis will remove 50%.

Take as directed, around-the-clock. Take full course of medication as ordered. Follow good hygiene measures to prevent reinfection. Frequent blood tests may be required. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Oropharyngeal Candidiasis

• Vaginal Candidiasis

• Fungal Infections (Tinea Strains)

• Cryptococcal Meningitis

• Coccidioidomycosis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Headache

• Rash

• Nausea

• Vomiting

• Abdominal Pain

• Diarrhoea

• Dizziness

• Hypokalemia

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• How long is the duration of effect?

  The action of this drug in the body lasts for up to 30 hours after administration.

• What is the onset of action?

  This drug starts its action within a couple of hours after oral use.

• Are there any pregnancy warnings?

  This drug is extremely unsafe to be used during pregnancy. Studies carried out on humans and animals have shown significant adverse effects on the fetus. Doctor consultation is recommended in such cases.

• Is it habit forming?

  It does not have addictive tendencies.

• Are there any breast-feeding warnings?

  The drug should not be consumed by breastfeeding mothers as there is a higher risk of side-effects on the infant. You are suggested to consult your doctor to discuss the potential benefits and risks before taking this medicine.

• Does this affect kidney function?

  Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Markzole 150 MG Tablet. Dosing adjustment/interval in renal impairment:

  • No adjustment for vaginal candidiasis single-dose therapy.
  • For multiple dosing, administer usual load then adjust daily doses.
  • Clcr 11-50 mL/minute: Administer 50% of recommended dose or administer every 48 hours.
  • Hemodialysis: One dose after each dialysis.
  • Continuous arteriovenous or venovenous hemodiafiltration (CAVH) effects: Dose as for Clcr 10-50 mL/minute.

• Does this affect liver function?

  No relevant information available. Consult your doctor before taking Markzole 150 MG Tablet.

• Is It safe with alcohol?

  Caution is advised in consuming alcohol, if you are taking this medicine. Please consult your doctor.

• Is it safe to drive while on this medicine?

  This medicine causes side effects that affect the alertness of the patients. Thus it influences the driving ability of the patient.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as Markzole 150 MG Tablet , and hence can be used as its substitute.

• Fabizol 150 MG Tablet

  Unichem Laboratories Ltd

• Glenflu 150 MG Tablet

  Glenmark Pharmaceuticals Ltd

• Fluzon 150 MG Tablet

  Cadila Pharmaceuticals Ltd

• Trucand 150 MG Tablet

  Abbott Healthcare Pvt. Ltd

• Ultican 150 MG Tablet

  Ochoa Laboratiories Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any missed dose instructions?

  Missed dose of this medication may be taken later unless it is already time for the next dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medication works by decreasing ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Microsporum.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Keep monitoring periodic liver function tests (AST, ALT, alkaline phosphatase) and renal function tests, potassium. As these might drastically be affected by the action of the Markzole 150 MG Tablet.

• Interaction with Medicine

  • Increased effect/toxicity:
  • Coadministration with terfenadine or cisapride is contraindicated; use with caution with astemizole due to increased risk of significant cardiotoxicity.
  • Hydrochlorothiazide may decrease fluconazole clearance.
  • Fluconazole may also inhibit warfarin, phenytoin, cyclosporine, and theophylline, zidovudine, sulfonylureas, rifabutin, and warfarin clearance.
  • Nephrotoxicity of tacrolimus may be increased.
  • Should be used with caution in patients receiving cisapride or astemizole.

• Interaction with Disease

  Should be used with caution in patients with renal and hepatic dysfunction or previous hepatotoxicity from other azole derivatives. Patients who develop abnormal liver function tests during fluconazole therapy should be monitored closely and discontinued if symptoms consistent with liver disease develop.

• Interaction with Food

  No data reported

• Ques : What is Markzole 150 MG Tablet?

  Ans : This drug decreases ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Microsporum.

• Ques : How long do I need to use Markzole 150 MG Tablet before I see improvement in my condition?

  Ans : This medication should be consumed, until the complete eradication of the disease. Thus it is advised to use, till the time directed by your doctor. Also taking this medication longer than it was prescribed, can cause an inadequate effect on the patient's condition.

• Ques : At what frequency do I need to use Markzole 150 MG Tablet?

  Ans : The duration of effect for this medicine is dependent on the severity of the patient’s condition. Therefore the frequency of usage of this medication will vary from person to person. It is advised to follow the proper prescription of the doctor, directed according to the patient's condition.

• Ques : Should I use Markzole 150 MG Tablet empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken after having food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Markzole 150 MG Tablet?

  Ans : This medication contains salts which are suitable to store only at room temperature, as keeping this medication above or below that, can cause an inadequate effect. Protect it from moisture and light. Keep this medication away from the reach of children.

• Ques : Can Markzole 150 MG Tablet be taken with oral contraceptives (OCPs) or birth control pills?

  Ans : Markzole 150 MG Tablet may interact with oral contraceptives having ingredients like estradiol. Hence, consult a doctor before taking them together.

• Ques : I feel better now, can I stop taking Markzole 150 MG Tablet?

  Ans : It is important to finish the course of treatment, hence one must not stop taking this drug if they start feeling better. If you stop taking it without any doctor consultation, then it may severely affect your medical condition.

• Ques : Is Markzole 150 MG Tablet safe to be used in pregnancy?

  Ans : This drug is not suitable for pregnant women as it can harm the baby. Consult a doctor and use some other alternative to this drug.

• Ques : Can Markzole 150 MG Tablet cause hair loss?

  Ans : Hair loss is a very unusual side effect of this medicine. If you encounter this symptom, then doctor consultation is suggested.

• Ques : Is Markzole 150 MG Tablet fungistatic or fungicidal?

  Ans : Markzole 150 MG Tablet is a fungistatic medication and helps in inhibiting the growth or bacteria. It also functions as a fungicidal (kills fungus) medicine against some specific organisms.

• Ques : Is Markzole 150 MG Tablet over the counter (OTC)?

  Ans : No, this medication is not available as an over the counter (OTC) drug. You must only take it if this medicine is prescribed by a healthcare professional.

• Ques : What if I forget to take a dose of Markzole 150 MG Tablet?

  Ans : Take the missed dose as soon as possible, however, skip the missed dose if it is almost the time for the next dose.

• Ques : Is Markzole 150 MG Tablet effective?

  Ans : It is an effective medication, however, you must consume it in dose and duration suggested by a medical expert.

• Ques : Does Markzole 150 MG Tablet treat bacterial vaginosis?

  Ans : This drug is not helpful against bacterial vaginosis. If you are suffering from bacterial vaginosis, do not take this drug, rather talk to a doctor to start a treatment.

• Ques : Does Markzole 150 MG Tablet make you feel tired?

  Ans : Tiredness is a common side effect reported after consumption of this medicine. You may want to take rest after consuming this medicine.

• Ques : Is Markzole 150 MG Tablet a steroid?

  Ans : This medicine is not a steroid, in fact it is an antifungal drug.

• Ques : Can I take Markzole 150 MG Tablet for yeast infection?

  Ans : This medication can be taken for a yeast infection. Please consult a doctor before taking it.

• Fluconazole-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/fluconazole

• -DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:

  https://go.drugbank.com/drugs/DB00196

• FLUCONAZOLE Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=FLUCONAZOLE