Mitigate TH Tablet

Mitigate TH Tablet is primarily known as a pain killer. It is primarily used to treat pain caused due to muscle spasm. This medication is a combination of Aceclofenac and Thiocolchicoside.

These two drug belongs to the class of non-steroidal anti-inflammatory drugs and natural anti-inflammatory glycosides, respectively. The drug combination works together and helps in improving muscle movement and also relieves discomfort and pain associated with the spasm.

This drug works by blocking the effect of cyclooxygenase (COX) enzymes which make chemical prostaglandins at sites of injury or damage causing pain, swelling and inflammation.

The side effects of this drug include nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, drowsiness, confusion, etc. You should not be taking this medicine if–

• You are allergic to this drug or other anti-inflammatory painkillers.
• You ever had a problem with stomach or duodenal bleeding.
• You have a heart condition or impaired kidney or liver function.
• You are pregnant or breastfeeding woman.
• You have high blood pressure or blood clotting problems.

This medication interacts with medicines like lithium, digoxin, corticosteroids, antihypertensives, etc and certain diseases like asthma, gastrointestinal toxicity. It can be taken with food or after food.

Drinking an adequate amount of water minimises chances of indigestion and stomach irritations. The duration and amount of medicine should be followed as per the doctor’s prescription.

• Muscle Spasm

• Allergy

• Asthma

• Bleeding

• Dizziness

• Visual Disturbances

• Flatulence

• Flushing

• Vomiting

• Stomach Pain

• Loss Of Appetite

• Heartburn

• How long is the duration of effect?

  This medicine is excreted in urine and the effect lasts for a duration of 12 to 16 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed in 1.5 to 3 hours after oral administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for pregnant women.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for breastfeeding women.

• Are there any missed dose instructions?

  Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.

• Are there any overdose instructions?

  A doctor should be contacted immediately if an overdose of Mitigate TH Tablet is suspected.

This medication is a combination of Aceclofenac and Thiocolchicoside, thus it works via a dual mechanism of action. The former drug, Aceclofenac, belongs to the class of a non-steroidal anti-inflammatory drug that helps relieve pain. Prostaglandins are responsible for pain, inflammation, swelling and fever. It inhibits the action of cyclooxygenase in the brain which is involved in the production of prostaglandins.

The latter constituent, Thiocolchicoside, is a derivative of glucoside, colchicoside that is contained within the Colchicum autumnale plant. It is a type of synthetic sulphur derivative. This medication has a high affinity for g-aminobutyric acid receptors. It activates GABA pathways and acts on the muscular contractures.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Ethanol

  This medicine should not be consumed with alcohol. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Medicine

  This drug interacts with lithium, methotrexate, mifepristone, anti-coagulants, zidovudine, etc.

• Interaction with Food

  Food

  Information not available.

• Ques : What is Mitigate TH Tablet?

  Ans : This medication is a combination of Aceclofenac and Thiocolchicoside. Both the drugs belong to the anti-inflammatory analgesic class. Thus it is primarily prescribed to treat pain occurred due to muscle spasm.

• Ques : How long do I need to use Mitigate TH Tablet before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

• Ques : At what frequency do I need to use Mitigate TH Tablet?

  Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Mitigate TH Tablet empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Mitigate TH Tablet?

  Ans : It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Aceclofenac- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/aceclofenac

• Aceclofenac- DrugBank [Internet]. Drugbank.ca. 2010 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB06736

• Thiocolchicoside- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/thiocolchicoside

• Thiocolchicoside- DrugBank [Internet]. Drugbank.ca. 2016 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB11582