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Overview

Neksium 40 MG Tablet

Manufacturer :  Astrazeneca Pharma India Ltd
Medicine Composition :  Esomeprazole
Prescription vs OTC : Prescription by Doctor not required

About Neksium 40 MG Tablet

Neksium 40 MG Tablet is used in the treatment of conditions caused by excessive production of acid in the stomach. The conditions may include erosive esophagitis, gastroesophageal reflux disease (GERD), Helicobacter pylori infection and Zollinger-Ellison syndrome (tumors in the pancreas or in the upper part of the small intestine).

Neksium 40 MG Tablet is used for short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.

It is also used for the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis; approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer.

Apart from that, it can also help in preventing stomach ulcer that is caused due to the consumption of nonsteroidal anti-inflammatory drugs (NSAID). The medication is available as a delayed-release capsule or in the form of a liquid suspension.

Belonging to the drug group of proton pump inhibitors, this medication blocks the proton pump in your stomach’s cells. When this proton pump gets blocked, there will be less production of acid in your stomach.

The dosage of this medication is decided by your doctor based on your age, the severity of the condition, your medical history and the reaction of your body after taking the first dose.

It should be kept in mind that this medicine is processed by the liver. If you have chronic liver disease, the body will be unable to process it well, causing a build-up of the drug. Also, this medicine can pass on to a child through his/her mother by breastfeeding. Hence, both pregnant and breastfeeding mothers must consult a doctor before taking the medication.

This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Omeprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.

Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.

The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.

Other possible (albeit rare) side effects include diarrhea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, and fever.

    What are the uses of Neksium 40 MG Tablet

    • Erosive Esophagitis

    • Gastroesophageal Reflux Disease

    • Helicobacter Pylori Infection

    • Zollinger-Ellison Syndrome

    • Other Forms Of Ulcers

    • Heartburn

    • Acidity

    What are the contraindications of Neksium 40 MG Tablet ?

    What are the side effects of Neksium 40 MG Tablet ?

    Key highlights of Neksium 40 MG Tablet

    • How long is the duration of effect?

      The effect of this medication lasts for a duration of about 16-18 hours.

    • What is the onset of action?

      The effect of this medication is usually observed in an hour of administration.

    • Are there any pregnancy warnings?

      This medication should be avoided by pregnant women. However, one must consult a doctor to know the risks and benefits associated with it.

    • Is it habit forming?

      No habit forming tendencies were reported for this medication.

    • Are there any breast-feeding warnings?

      This medication should not be used by breastfeeding mothers. Doctor consultation is recommended.

    • Is It safe with alcohol?

      Caution must be taken. Avoid consuming alcohol along with this medicine.

    • Is it safe to drive while on this medicine?

      It is unknown whether this medicine alter the ability of patients driving skills. It patient experience any side effects, he must avoid driving.

    • Does this affect kidney function?

      It is safe to use Neksium 40 MG Tablet in patients with kidney disease.

    • Does this affect liver function?

      Caution must be taken in patients with liver disease. Adjustment of dose is needed, kindly consult your doctor before taking this medication.

    What are the substitutes for Neksium 40 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Neksium 40 MG Tablet , and hence can be used as its substitute.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose should be skipped.

    • Are there any overdose instructions?

      Contact your doctor immediately if an overdose is suspected.

    How does this medication work?

    This medication is a proton pump inhibitor drug and binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

      What are the interactions of Neksium 40 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Lab Test

        Neuroendocrine tumor diagnosis

        This medication should not be used while undergoing the neuroendocrine/carcinoid tumor test as it might give a false-positive result for this diagnostic test.
      • Interaction with Medicine

        Do not use this medication in combination with Clopidogrel, Ketoconazole, Methotrexate, Warfarin, Nelfinavir and Digoxin.
      • Interaction with Disease

        Patients who suffer from Liver Disease, Osteoporosis and Hypomagnesemia should avoid taking this medication.

      FAQs about Neksium 40 MG Tablet

      • Ques : What is Neksium 40 MG Tablet?

        Ans : This medication has Esomeprazole as active ingredients present. It performs its action by obstructing the release of acetylcholine (chemical messengers) in the brain.

      • Ques : What are the uses of Neksium 40 MG Tablet?

        Ans : This medication is used for the treatment and prevention from conditions and symptoms of diseases like gastroesophageal reflux disease, helicobacter pylori Infection and Zollinger-Ellison syndrome.

      • Ques : What are the Side Effects of Neksium 40 MG Tablet?

        Ans : This is a list of possible side-effects which may occur due to the constituting ingredients of this medication. These include vomiting, diarrhea, headache, abdominal pain, flatulence, constipation, stomach disorders, and nausea.

      • Ques : What are the instructions for storage and disposal Neksium 40 MG Tablet?

        Ans : This medication should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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