Nexpro 40 MG Tablet

Nexpro 40 MG Tablet is used in the treatment of conditions caused by excessive production of acid in the stomach. The conditions may include erosive esophagitis, gastroesophageal reflux disease (GERD), Helicobacter pylori infection and Zollinger-Ellison syndrome (tumors in the pancreas or in the upper part of the small intestine).

Nexpro 40 MG Tablet is used for short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.

It is also used for the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis; approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer.

Apart from that, it can also help in preventing stomach ulcer that is caused due to the consumption of nonsteroidal anti-inflammatory drugs (NSAID). The medication is available as a delayed-release capsule or in the form of a liquid suspension.

Belonging to the drug group of proton pump inhibitors, this medication blocks the proton pump in your stomach’s cells. When this proton pump gets blocked, there will be less production of acid in your stomach.

The dosage of this medication is decided by your doctor based on your age, the severity of the condition, your medical history and the reaction of your body after taking the first dose.

It should be kept in mind that this medicine is processed by the liver. If you have chronic liver disease, the body will be unable to process it well, causing a build-up of the drug. Also, this medicine can pass on to a child through his/her mother by breastfeeding. Hence, both pregnant and breastfeeding mothers must consult a doctor before taking the medication.

This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Omeprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.

Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.

The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.

Other possible (albeit rare) side effects include diarrhea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, and fever.

• Erosive Esophagitis

• Gastroesophageal Reflux Disease

• Helicobacter Pylori Infection

• Zollinger-Ellison Syndrome

• Other Forms Of Ulcers

• Heartburn

• Acidity

• Allergy

• Abdominal Pain

• Fever

• Joint Pain

• Sore Throat

• Loss Of Appetite

• Constipation

• Diarrhoea

• Difficulty In Breathing

• Dizziness

• Muscle Pain

• Drowsiness

• Rash

• Back Pain

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 16-18 hours.

• What is the onset of action?

  The effect of this medicine can be observed within an hour of administration.

• Are there any pregnancy warnings?

  The medicine should not be consumed by breastfeeding mothers as there is a higher risk of side-effects on the infant. You are suggested to consult your doctor to discuss the potential benefits and risks before taking this medicine.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for use by breastfeeding women as it may cause some harm to the infant. However, if it is absolutely necessary to use this medicine, then breastfeeding should be discontinued. Consult your doctor before taking this medicine.

• Is It safe with alcohol?

  It is not advised to consume alcohol while taking this medicine.

• Is it safe to drive while on this medicine?

  It is not known whether this medicine affects the patients ability to drive.

• Does this affect kidney function?

  It is found to be safe to use this medicine in patients with kidney disease, Adjustment of dose is not needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken while taking this medicine is patients with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

Below is the list of medicines, which have the same composition, strength and form as Nexpro 40 MG Tablet , and hence can be used as its substitute.

• Esoz Fast 40 MG Tablet

  Glenmark Pharmaceuticals Ltd

• Espra 40 MG Tablet

  Zydus Cadila

• Esofine 40 MG Tablet

  Macleods Pharmaceuticals Pvt.Ltd

• Raciper Sf 40 MG Tablet

  Ranbaxy Laboratories Ltd

• Oskar-S 40 MG Tablet

  Mankind Pharmaceuticals Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose should be skipped.

• Are there any overdose instructions?

  Contact your doctor immediately if an overdose is suspected. Symptoms may include confusion, drowsiness, blurred vision, dry mouth, and headache.

This medicine is a proton pump inhibitor drug and binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Lab Test

  Neuroendocrine tumor diagnosis

  This medication should not be used while undergoing the neuroendocrine/carcinoid tumor test as it might give a false-positive result for this diagnostic test.

• Interaction with Medicine

  • Clopidogrel : Report the use of either of the medicine to the doctor. Your doctor may prescribe a safer alternative for reducing the stomach acidity while you are being treated with Clopidogrel.
  • Ketoconazole : This medication should be used with Ketoconazole or other antifungals of the same group with caution. Inform the doctor about the usage of either of these medications so that safer alternatives can be prescribed.
  • Methotrexate : This medication should not be used with Methotrexate. The use of either of the drugs should be reported to the doctor so that a safer substitute could be prescribed.
  • Warfarin : Usage of this medication with Warfarin should be strictly monitored by the doctor. Suitable adjustment in dosage and monitoring of Prothrombin time is necessary to ensure safety. Any symptoms like unusual bleeding, swelling, vomiting, or presence of blood in urine should be reported immediately.
  • Nelfinavir : This medication is not recommended for use when the patient is already taking anti-viral medications like Nelfinavir or other drugs used in the management of HIV Infection.
  • Digoxin : This medication should be used with caution if the patient is on Digoxin. Prior usage of any of these drugs should be informed to the doctor. Any symptoms like nausea, vomiting, diarrhea, loss of appetite, disturbances in vision, and abnormalities in heartbeat should be reported immediately.

• Interaction with Disease

  • Liver Disease: Any history of liver disease has to be reported to the doctor. Suitable dose adjustment is required based on the extent of the liver impairment.
  • Osteoporosis: Suitable dose adjustment have to be made in patients who suffer from Osteoporosis related fracture.
  • Hypomagnesemia: Inform your doctor about magnesium level imbalance in the body. Regular monitoring is advised for patients taking Esomeprazole in such cases.

• Ques : What is Nexpro 40 mg tablet?

  Ans : Nexpro Tablet is a medication which has esomeprazole as an active element present in it. This medicine performs its action by reducing the amount of acid produced in the stomach.

• Ques : What are the uses of Nexpro 40 mg tablet?

  Ans : This tablet is a medication, which is used for the treatment and prevention from conditions such as Gastroesophageal reflux disease, Peptic ulcer, and Gastric ulcers, etc.

• Ques : What are the Side Effects of Nexpro 40 mg tablet?

  Ans : This medication which has some commonly reported side effects such as Headache, Nausea, Flatulence, Stomach pain, Skin rash, Swelling and redness at the injection site, Difficulty in breathing, Swelling of face, lips, etc.

• Ques : What are the instructions for storage and disposal Nexpro 40 mg tablet?

  Ans : Nexpro should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : How long do I need to use Nexpro 40 MG Tablet before I see improvement of my conditions?

  Ans : Nexpro is a medicine which takes 1 or 2 days before you see an improvement in your health conditions. It would be ideal if you note, it doesn't mean you will begin to notice such health improvement in a similar time span as different patients.

• Ques : What are the contraindications to Nexpro 40 MG Tablet?

  Ans : Contraindication to Nexpro. In addition, this medication should not be used if you have the following conditions such as tightening of the airway muscles, swelling of the lower layer of the skin, swelling in between the kidney tubules, hives, etc

• Ques : Is Nexpro 40 MG Tablet safe to use when pregnant?

  Ans : This medication is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

• Ques : Will Nexpro 40 MG Tablet be more effective if taken in more than the recommended dose?

  Ans : No, taking higher than the recommended dose of Nexpro can lead to increased chances of side effects such as acne, constipation, cramps, diarrhea, dry mouth, excessive production of urine, etc.

• Esomeprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 24 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/esomeprazole

• Esomeprazole- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 10 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00736

• Esomeprazole, Uses, Side Effects And Doses- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 15 May 2019]. Available from:

  https://www.drugsbanks.com/esomeprazole/