Nicodol Plus 325 Mg/37.5 Mg Tablet

Nicodol Plus 325 Mg/37.5 Mg Tablet is used a pain-relieving medication. It is primarily used to treat acute pain. The conditions of acute pain include backache, headache, arthritis and toothache, etc.

This medication is a combination of paracetamol and tramadol. These drugs fall under the class of analgesics, belonging to the category of NSAID and opioid agonist, respectively. This medication also reduces pain in the body caused due to fever.

You should not consume this tablet if:

• You are allergic to this medicine.
• You are suffering from a serious liver disorder.
• You normally consume more than 3 alcohol beverages per day or have a history of alcoholism.

You must not take the medicine in more than the amount prescribed or longer than the prescribed period. It can be taken with food or without it, but you must take it, in the same way, every day.

The medicine must be swallowed whole, without trying to crush, break or mixing it in water. As it is a pain reliever, it is unlikely that you will miss a dose. In case you do, refrain from taking two doses together to make up for the missed one.

• Acute Pain

• Allergy

  Nicodol Plus 325 Mg/37.5 Mg Tablet is not recommended if you have a known allergy to this medicine.

• Analgesic Nephropathy (Kidney Disease)

  Nicodol Plus 325 Mg/37.5 Mg Tablet is not recommended if you suffer from impaired kidney function due to excessive usage of painkillers or otherwise.

• Liver Disease

  Nicodol Plus 325 Mg/37.5 Mg Tablet is metabolised by the liver and is not recommended if you suffer from impaired liver function.

• Nausea Or Vomiting

• Allergic Skin Reaction

• Gastric / Mouth Ulcer

• Anemia

• Fatigue

• Stevens-Johnson Syndrome (Sjs)

• How long is the duration of effect?

  The effect lasts for an average of 4-6 hours.

• What is the onset of action?

  The effect of Paracetamol (primary constituent of Nicodol Plus 325 Mg/37.5 Mg Tablet) can be observed within an hour of oral administration. When given in the form of an intravenous injection, the pain-relieving action starts in 5-10 minutes. For fever reduction, the time taken is about 30 minutes.

• Are there any pregnancy warnings?

  This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor. Oral administration of the medicine should be preferred over intravenous route.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is safe to use during breastfeeding. It is advised to consult your doctor before taking this medicine. Any incidence of rashes on skin or diarrhea in the infant should be reported.

Below is the list of medicines, which have the same composition, strength and form as Nicodol Plus 325 Mg/37.5 Mg Tablet , and hence can be used as its substitute.

• Tramacad P 325 Mg/37.5 Mg Tablet

  Cadila Pharmaceuticals Ltd

• Trson P 325Mg/37.5Mg Tablet

  Unison Pharmaceuticals Pvt Ltd

• Synerdol Forte 325 Mg/37.5 Mg Tablet

  Seagull Labs (I) Pvt Ltd

• Tram Proxyvon 325 Mg/37.5 Mg Capsule

  Wockhardt Ltd

• Rosetra P 325 Mg/37.5 Mg Tablet

  Almet Corporation Ltd

• Kamadol P 325Mg/37.5Mg Tablet

  Karnataka Antibiotics & Pharmaceuticals Ltd

• Dol A 325 Mg/37.5 Mg Tablet

  Serve Pharmaceuticals

• Pentazen 325 mg/37.5 mg Tablet

  Ind Swift Laboratories Ltd

• Parexia T 325 mg/37.5 mg Tablet

  Heal India Laboratories

• Osteodol 325 mg/37.5 mg Tablet

  Dabur India Ltd

• Missed Dose instructions

  Nicodol Plus 325 Mg/37.5 Mg Tablet is usually taken as and when required. If the medicine is taken on a regular basis, then the missed dose should be taken as soon as possible. You should not take the missed dose if it is time for taking the next scheduled dose.

• Are there any overdose instructions?

  Nicodol Plus 325 Mg/37.5 Mg Tablet overdosage could cause harmful effects to the body. Early symptoms are loss of appetite, nausea, vomiting, stomach pain while late symptoms include yellowing of skin and eye, severe abdominal pain and dark color urine.

This medication is a combination of Paracetamol and Tramadol. Both the drugs fall under the class of analgesic. Thus medications produce its action following two different paths of the mechanism of action.

Firstly, it selectively inhibits enzyme function in the brain which allows it to treat pain and fever. It activates certain receptors in the brain that inhibit pain signals.

Secondly, it acts on certain specific pain receptors in the brain and inhibits the reuptake of norepinephrine, serotonin. It also enhances the release of serotonin thereby changing the perception and response to pain.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  N/A

  You should avoid consuming alcohol while taking this medicine. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.

• Interaction with Lab Test

  5-HIAA Urine Test

  You may get a false-positive result for this test if you take Nicodol Plus 325 Mg/37.5 Mg Tablet.

• Interaction with Medicine

  Carbamazepine

  Nicodol Plus 325 Mg/37.5 Mg Tablet should not be taken with Carbamazepine. Usage of either of the drugs should be reported to the doctor. Any symptoms like fever, chills, joint pain, skin rash, loss of appetite should be reported promptly.

  Phenytoin

  Nicodol Plus 325 Mg/37.5 Mg Tablet should not be taken with Phenytoin. Usage of either of the drugs should be reported to the doctor. Any symptoms like fever, chills, joint pain, skin rash, loss of appetite should be reported promptly.

  Sodium Nitrite

  Nicodol Plus 325 Mg/37.5 Mg Tablet should not be taken while on Sodium Nitrite. Symptoms like discoloration of skin, rashes, headache, dizziness, increased heartbeat should be promptly reported to the doctor.

  Leflunomide

  Nicodol Plus 325 Mg/37.5 Mg Tablet should not be taken while on leflunomide. Usage of either of the drug should be reported to the doctor. Symptoms like fever, chills, nausea, yellowing of skin should be promptly reported.

  Prilocaine

  Nicodol Plus 325 Mg/37.5 Mg Tablet should not be taken while on Prilocaine. Symptoms like discoloration of skin, rashes, headache, dizziness, increased heartbeat should be promptly reported to the doctor.

• Interaction with Disease

  Alcoholism

  This medicine should be given with extreme caution if you are a chronic alcoholic. Usage of alcohol should be avoided and any symptoms like nausea, fever, rashes, darkened urine should be reported to the doctor on priority.

  Liver Disease

  Nicodol Plus 325 Mg/37.5 Mg Tablet should be given with extreme caution to if you are suffering from impaired liver functioning disease. Symptoms like nausea, fever, rashes, darkened urine should be reported to the doctor on priority. Clinical monitoring of liver function should be done at regular intervals.

• Interaction with Food

  Food

  Information not available.

• Ques : What is Nicodol Plus 325 Mg/37.5 Mg Tablet?

  Ans : This medication performs its action by obstructing the release of pain and fever chemical messengers.

• Ques : What are the uses of Nicodol Plus 325 Mg/37.5 Mg Tablet?

  Ans : It is used for the treatment and prevention from conditions and symptoms of diseases like Post immunization pyrexia, menstrual cramps and fever.

• Ques : What are the Side Effects of Nicodol Plus 325 Mg/37.5 Mg Tablet?

  Ans : Allergic reaction, gastric ulcers, fatigue, anemia, nausea and vomiting are possible side effects.

• Ques : What are the instructions for storage and disposal Nicodol Plus 325 Mg/37.5 Mg Tablet?

  Ans : This medicine should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Ques : Should I use Nicodol Plus 325 Mg/37.5 Mg Tablet empty stomach, before food or after food?

  Ans : If you take this medication with the food, the reactions that took place in the body carry-outs in a much effective manner.

• Ques : How long do I need to use Nicodol Plus 325 Mg/37.5 Mg Tablet before I see improvement of my conditions?

  Ans : This medication should be consumed, until the complete eradication of the disease. It is advised to use, till the time directed by your doctor.

• Ques : Is there any food or drink I need to avoid?

  Ans : You can follow your normal diet under the usage of this medication.

• Ques : Will Nicodol Plus 325 Mg/37.5 Mg Tablet be more effective if taken in more than the recommended dose?

  Ans : There is no need to take this medication more than its recommended doses.

• Acetaminophen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 10 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/paracetamol

• Acetaminophen- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 10 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00316

• Tramadol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 10 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/tramadol

• Tramadol- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 10 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00193