Norlox Tz Tablet

Norlox Tz Tablet is a combination medicine that is used to cure bacterial infections. It is primarily used to treat diarrhoea and dysentery. It is a combination of two antibiotics Norfloxacin and Tinidazole.

However, remember that this drug will not be effective for infections that aren’t caused by bacteria (viral infections such as common cold and the flu). Using an antibiotic repetitively and for infections that aren’t bacterial will lead the medicine to lose its potency over a period of time.

The treatment plan and dosage will depend upon the severity of the condition. It is advised to take this drug minimum two hours prior to consuming other minerals/vitamins or such products containing aluminium/magnesium such as antacids.

For best results, take this medicine at regular intervals every day. Try to limit your intake of caffeinated beverages such as coffee or tea, for that matter, as caffeine can interfere with the medicine’s potency in all probability. Don’t consume any dairy product either two hours prior to or an hour after taking this medication.

Risk factors for this medicine include kidney disorders, heart afflictions and epileptic seizures. It isn’t recommended for children below the age of 12 years. Overdosing on this medicine can result in irregular (slow) heartbeats.

Few side effects include an allergic response in the form of rashes, irritation of the skin, itching, etc. (though very rare), chest pain, dizziness, confusion, seizures, liver damage, joint or muscle pain, a ringing sensation in the ears (tinnitus), lightheadedness, diarrhea, fatigue, nausea, headaches and troubled sleeping.

Don’t take narcotic pain medicines if you experience any of these side effects since these can cause you more harm than good. Yeast infection and oral thrush are other concerns that might show up if you use this medicine indiscriminately. Know from your doctor the names of all those drugs that could diminish the efficacy of this medication.

• Diarrhoea

• Dysentery

• Allergy

  Avoid taking Norlox Tz Tablet if you have a known allergy to this medicine or any other medicines belonging to the class fluoroquinolones.

• Tendinitis Or Tendon Rupture

  Avoid taking this medicine if you have a past history of tendinitis or tendon rupture after using Norlox Tz Tablet.

• Myasthenia Gravis

  Avoid taking this medicine if you have a past or family history of Myasthenia Gravis (weakness and rapid fatigue of muscles under voluntary control).

• Nausea Or Vomiting

• Dizziness

• Headache

• Abdominal Pain

• Weakness

• Constipation

• Back Pain

• Flatulence

• Heartburn

• Skin Rash

• Metallic Taste

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 9 to 12 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed in 1 to 2 hours.

• Are there any pregnancy warnings?

  This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Use of this medicine is not recommended in women who breastfeed due to the adverse effect on the development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Monitoring of undesired effects like diarrhea, diaper rash is necessary.

Below is the list of medicines, which have the same composition, strength and form as Norlox Tz Tablet , and hence can be used as its substitute.

• Norstar Tz Tablet

  Cadila Pharmaceuticals Ltd

• Norflowok Tz 400Mg/600Mg Tablet

  Wockhardt Ltd

• Noxitef Tz 400Mg/600Mg Tablet

  Leeford Healthcare Ltd

• Loc 400 mg/600 mg Tablet

  Omega Remedies Pvt Ltd

• INOR-T TABLET

  Noel Pharma India Pvt Ltd

• LOXONE TZ 400MG/600MG TABLET

  Micro Labs Ltd

• Nor-Tz Tablet

  Alkem Laboratories Ltd

• Nordys 400Mg/600Mg Tablet

  Micro Labs Ltd

• Norcip TZ Tablet

  PCI Pharmaceuticals

• Enteroflox T 400 Mg/600 Mg Tablet

  Deys Medical

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

This medicine is a combination of Norfloxacin and Tinidazole. These drugs are antibiotic and belong to fluoroquinolone and anthelmintics, respectively. Thus it works following a dual mechanism.

Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death.

Secondly, it enters into the organism and forms the free radical. A concentration gradient is created in the organism due to alteration in the molecule and promotes the influx of the molecule. Thus, the free radical and the altered molecule will interfere with the DNA synthesis and stops the growth of the organism.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Escitalopram

  You may experience dizziness, lightheadedness, shortness of breath, or heart palpitations if these medicines are used together. This interaction is more likely to happen if you suffer from any heart disease (Arrhythmia) or have a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Ethinyl Estradiol

  The desired effect of contraceptive pills will not be achieved if these medicines are used together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

  Corticosteroids

  You may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.

  Aspirin

  You may experience tremors, involuntary muscle movements, hallucinations, or seizures if these medicines are used together. This interaction is more likely to happen if you have a history of seizures or family history of seizures. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Antidiabetic drugs

  You may experience hypoglycemic effects like dizziness, headache, nervousness, confusion, tremor and weakness if these medicines are used together. Hyperglycemic effects like increased thirst, urination and hunger are less likely to occur. Regular blood glucose checkups are to be performed if you are diabetic or if you are suffering from any kidney disease. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Warfarin

  Tinidazole may increase the concentration of warfarin and increase the risk of bleeding. Inform the doctor if you have any bleeding disorder. Any symptoms of unusual bleeding, blood in stools, headache, and dizziness should be reported to the doctor. An alternate class of medicine should be considered based on the clinical condition.

  Disulfiram

  Tinidazole is not recommended in patients receiving disulfiram due to the risk of confusion and psychotic symptoms. Inform the doctor if you are receiving these medications. Any symptoms of change in behavior, irritation, and altered coordination should be reported to the doctor.

• Interaction with Disease

  Central Nervous System Depression

  If you suffer from CNS disorder and you take Norlox Tz Tablet, then you may experience tremors, restlessness, anxiety, confusion and hallucinations. Avoid consuming caffeine-containing products like coffee, chocolates and energy drinks.

  Qt Prolongation

  Avoid using Norlox Tz Tablet if you experience any chest discomfort. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.

  Colitis

  Avoid taking Norlox Tz Tablet if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

• Interaction with Food

  Dairy products

  The desired effect of Norlox Tz Tablet is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Norlox Tz Tablet and dairy products.

• Ques : What is Norlox Tz Tablet?

  Ans : This medication is a combination medicine of two antibiotics Norfloxacin and Tinidazole. These two drugs belongs to the class of fluoroquinolone and anthelmintics, respectively. It is primarily used to treat diarrhoea and dysentery.

• Ques : How long do I need to use Norlox Tz Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Norlox Tz Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Norlox Tz Tablet empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Norlox Tz Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Norfloxacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/norfloxacin

• Norfloxacin- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01059

• Tinidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/tinidazole

• Tinidazole- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00911