Norpregalin 75mg/10mg Tablet

Norpregalin tablet is composed of Pregabalin and Nortriptyline. It is an anticonvulsant and is considered to be the first-line of treatment for neurotic pain, shingles, seizures and fibromyalgia. It is used for the treatment of diabetic nerve pain, epilepsy, spinal cord injury, restless leg syndrome and generalised anxiety disorder.This medication works by binding to a certain region of the brain and reducing the pain signals sent out by the damaged nerves of the body.

Ensure your doctor is informed if you have any of the following medical conditions before starting the medication:

• If you have congestive heart failure, irregular heartbeat, diabetes, bleeding problems, muscle problems, highballed pressure or low platelet count.
• If you have improper kidney functioning or are on dialysis.
• If you have a history of angioedema.
• If you are pregnant, planning to be pregnant or are breastfeeding.
• If you take any other medicines, dietary supplements or herbal preparations.
• If you have mental or mood problems, suicidal thoughts, or are dealing with depression.

• Peripheral Neuropathy

• Postherpetic Neuralgia

• Allergy

• Myocardial Infarction

• Dizziness

• Drowsiness

• Peripheral Edema

• Nausea

• Blurred Vision

• Dry Mouth

• Weight Gain

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 10-12 hours.

• What is the onset of action?

  This medicine has a varying onset time depending on the intended use.

• Are there any pregnancy warnings?

  Pregnant women must consult doctor before using this medication.

• Is it habit forming?

  This medicine has a low abuse potential with limited physical and psychological dependence.

• Are there any breast-feeding warnings?

  Use of this medicine by breastfeeding women is not recommended. However, if it becomes necessary to use this medicine, then breastfeeding should be discontinued. Consult your doctor before using this medicine.

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

• Are there any overdose instructions?

  Contact your doctor immediately if an overdose is suspected.

This medication is a combination of Pregabalin and Nortriptyline, thus work through a dual mechanism of action. Primarily, it behaves as a GABA analogue and binds to the voltage-gated calcium channels in the central nervous system. This causes a reduced release of neurotransmitters like serotonin, dopamine, substance P thus slowing down nerve signals. Secondarily, it blocks the serotonin reuptake at the neuronal membrane. Also, it inhibits the reuptake of norepinephrine and raises its concentration in the synaptic cleft.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Ethanol

  Avoid or limit the use of alcohol while taking this medicine. One should refrain from operating heavy machinery or performing works that require a high level of mental alertness.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Medicine

  This medication interacts with Buprenorphine, Metoprolol, Oxycodone, Propoxyphene and others.

• Interaction with Food

  Food

  Information not available.

• Interaction with Disease

  Disease

  Do not use this medication if you suffer from Heart Disease, Angioedema and others.

• Ques : What is Norpregalin 75mg/10mg Tablet?

  Ans : This medication is a combination of Pregabalin and Nortriptyline and is considered to be the first-line of treatment for neurotic pain, shingles, seizures and fibromyalgia.

• Ques : What are the uses of Norpregalin 75mg/10mg Tablet?

  Ans : Norpregalin is used for the treatment and prevention from conditions such as neuropathic pain.

• Ques : What are the Side Effects of Norpregalin 75mg/10mg Tablet?

  Ans : Side effects include Constipation, Difficulty in urination, Weight gain, Sleepiness, Dizziness, Tiredness, Blurred vision, Dryness in the mouth, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing), and Uncoordinated body movements.

• Ques : What are the instructions for storage and disposal Norpregalin 75mg/10mg Tablet?

  Ans : Nor Pregalin should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets.

• Ques : How long do I need to use Norpregalin 75mg/10mg Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Nortriptyline- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/pregabalin

• Pregabalin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/nortriptyline

• Nortriptyline 10 mg Film-coated Tablets [Internet]. medicines.org.uk 2019 [Cited 23 January 2020]. Available from:

  https://www.medicines.org.uk/emc/medicine/32962