Novaclav-625 Tablet

Novaclav-625 Tablet is prescribed for the treatment of otitis media, sinusitis, and infections caused by susceptible organisms involving the lower respiratory tract, skin and skin structure, and urinary tract. This is a combination medication that has Amoxycillin and Clavulanic Acid as active ingredients. Its spectrum is the same as amoxicillin with additional coverage of beta-lactamase.

The extended coverage Novaclav-625 Tablet is due to its combination, which makes it a useful alternative when amoxicillin resistance is present and patients cannot tolerate alternative treatments.

Novaclav-625 Tablet is an antibiotic belonging to the class of penicillin antibiotic that helps in the treatment of bacterial infections. The medicine works against the synthesis of the bacteria. It also treats conditions like gonorrhoea, tonsillitis, infection in the eye, middle ear or nose. It is important that you do not consume this tablet for cold, flu or other viral infections.

Symptoms of penicillin overdose include neuromuscular hypersensitivity (agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures) and electrolyte imbalance with potassium or sodium salts, especially in renal failure.

Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise most treatment is supportive or symptom directed.

Take entire prescription, even if you are feeling better. Take at equal intervals around-the-clock; may be taken with milk, juice, or food. You may experience nausea or vomiting (small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help).

If using oral contraceptives, use additional contraceptive measures; amoxicillin may reduce the effectiveness of your oral contraceptive. Report rash; unusual diarrhoea; vaginal itching, burning, or pain; unresolved vomiting or constipation; fever or chills; unusual bruising or bleeding; or if the condition being treated worsens or does not improve by the time prescription is completed.

• Bacterial Infections

• Urinary Tract Infection

• Typhoid Fever

• Cystitis

• Prostatitis

• Sinusitis

• Skin Infection

• Bone And Joint Infections

• Allergy

• Rash

• Urticaria

• Nausea

• Vomiting

• Diarrhoea

• Headache

• Abdominal Discomfort

• Flatulence

• How long is the duration of effect?

  The effect of this medicine lasts for an average of 1.5 to 2 hours after onset of action.

• What is the onset of action?

  It will take between 1-2 hours after the administration of the medicine before it takes effect. This duration may vary depending on the age of the patient and the dosage prescribed.

• Are there any pregnancy warnings?

  Pregnant women should consume the drug only if there is a great need for the same. Furthermore, the need should outweigh the risks involved with the drug. Consult your doctor before taking Novaclav-625 Tablet during pregnancy.

• Is it habit forming?

  The drug does not have any habit forming tendencies, but you should stick to the recommended dosage and course length to avoid any health complications.

• Are there any breast-feeding warnings?

  It is generally better to avoid the medicine while you are breastfeeding. However, if you must take it, consult your physician, so that he/she may look for alternatives or enforce preventive measures to avoid harm befalling the baby.

• Is It safe with alcohol?

  Interaction of the drug with alcohol is unknown, but you should seek advice from your physician regarding mixing a dose of the drug with alcohol.

• Is it safe to drive while on this medicine?

  Driving is safe, as long as you do not experience side effects, such as drowsiness. If you do feel sleepy after consuming the medicine, avoid driving or operating any heavy machinery.

• Does this affect kidney function?

  If you suffer from kidney disorders, you should exercise extreme caution while using the drug. If severe kidney diseases affect you, you should avoid Novaclav-625 Tablet altogether, as it can lead to complications.

• Does this affect liver function?

  Patients suffering from liver disease should try to avoid the medicine. However, if prescribed, the doctor may adjust the dosage to ensure that the drug do not adversely affect the organ. Furthermore, such patients should undergo tests to monitor liver functionality.

Below is the list of medicines, which have the same composition, strength and form as Novaclav-625 Tablet , and hence can be used as its substitute.

• Amoxy Plus 500 Mg/125 Mg Tablet

  Symbiosis Lab

• Clav Den 625mg Tablet

  Ind Swift Laboratories Ltd

• Themiclav 500Mg/125Mg Tablet

  Themis Medicare Ltd

• Clavituf 500 Mg/125 Mg Tablet

  Intas Pharmaceuticals Ltd

• Clavoford 500Mg/125Mg Tablet

  Oxford Pharmaceuticals Pvt Ltd

• Clarence 500 Mg/125 Mg Tablet

  Khandelwal Laboratories Pvt Ltd

• Xoclave 500 mg/125 mg Tablet

  Corona Remedies Pvt Ltd

• Princiclav 500 mg/125 mg Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Sensiclav 625 Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Polyclav 625Mg Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. However, if it is already time to take your next dose, do not take two doses at once. Missed doses can limit the effectiveness of the Antibiotic.

• Are there any overdose instructions?

  If you overdose on Novaclav-625 Tablet, you will likely experience certain symptoms, such as Diarrhea, Drowsiness, Nausea, Vomiting, Etc. Under such a circumstance, visit your nearest emergency room or clinic immediately to receive treatment and support.

This medicine works via dual mechanism. Firstly, Clavulanic acid binds and inhibits beta-lactamases that inactivate amoxicillin resulting in amoxicillin having an expanded spectrum of activity. Secondly, Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Even though interaction with alcohol has not been proven, you should consult your doctor if you are planning to consume alcoholic drinks during the course of the medication.

• Interaction with Medicine

  Novaclav-625 Tablet can interact with certain medicines or supplements to cause severe side effects. You must discuss the medicines you currently are taking with the doctor so that he/she can prescribe your substitutes.

  • Doxycycline, methotrexate, warfarin, ethinylestradiol and live vaccines are some of the medicines that interact with this medication to cause adverse side effects.
  • Decreased effect: Efficacy of oral contraceptives may be reduced.
  • Increased effect: Disulfiram, probenecid may increase amoxicillin levels, increased effect of anticoagulants.
  • Increased toxicity: Allopurinol theoretically has an additive potential for amoxicillin rash.

• Interaction with Disease

  In patients with renal impairment, doses and/or frequency of administration should be modified in response to the degree of renal impairment; high percentage of patients with infectious mononucleosis have developed rash during therapy; a low incidence of cross-allergy with cephalosporins exists; incidence of diarrhea is higher than with amoxicillin alone. Hepatic dysfunction, although rare, is more common in elderly and/or males, and occurs more frequently with prolonged treatment.

• Interaction with Food

  Generally antibiotics are taken after meals. Therefore, the drug does not interact adversely with your foods. However, consult the physician to get a clearer idea about how and when to take the medicine. May mix with milk, formula, or juice.

• Ques : What is Novaclav-625 Tablet?

  Ans : Novaclav-625 Tablet is a medication which has Amoxycillin and Clavulanic Acid as active ingredients present in it. Being a combination of Amoxycillin and Clavulanic Acid. amoxicillin is an antibiotic. It works by avoiding the formation of the bacterial protective covering which is important for the growth of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which decreases resistance and improves the activity of amoxicillin against bacteria. Novaclav-625 Tablet is used to treat conditions such as bacterial infection, stomach ulcers, skin infection, etc.

• Ques : What is the use of Novaclav-625 Tablet?

  Ans : Novaclav-625 Tablet is a medication which is used for the treatment, control, and prevention of the below mentioned conditions such as:

  1. Ear Infection (Otitis Media)
  2. Nose Infection (Sinusitis)
  3. Throat Infection (Tonsillitis/Pharyngitis)
  4. Lower Respiratory Tract Infection
  5. Skin Infection
  6. Urinary Tract Infection
  7. Stomach Ulcers
  8. Febrile Neutropenia

• Ques : What are the side effects of Novaclav-625 Tablet?

  Ans : Novaclav-625 Tablet is a medication which has some known side effects which may or may not occur always and some of them are rare but serious. If you observe any of the below mentioned side effects, contact your doctor immediately.

  Here is a complete list of side effects caused by Novaclav-625 Tablet, which are listed below:

  1. Allergic Skin Reaction
  2. Diarrhea
  3. Fever
  4. Joint pain
  5. Skin yellowing
  6. Easy bruising and bleeding
  7. Heavy menstrual bleeding
  8. Tooth discoloration
  9. Nausea or vomiting
  10. Altered sense of taste
  11. Convulsions
  12. Painful intercourse
  13. Swelling of face, lips, eyelids, tongue, hands and feet
  14. Black or tarry stools
  15. Muscle or joint pain
  16. Sleeplessness
  17. Irregular heartbeat

• Ques : Can Novaclav-625 Tablet cause allergic reaction?

  Ans : Yes, Novaclav-625 Tablet is a medication which can cause an allergic reaction and is considered to be harmful to patients with known allergy to penicillins. Get medical help if you observe any signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue or throat. It is a prescribed medication which should only be taken on a prescription.

• Ques : How long do I need to use Novaclav-625 Tablet before I see improvement in my condition?

  Ans : This medication should be consumed, until the complete eradication of the disease. Thus it is advised to use, till the time directed by your doctor. Also taking this medication longer than it was prescribed, can cause an inadequate effect on the patient's condition. So please consult your doctor.

• Ques : At what frequency do I need to use Novaclav-625 Tablet?

  Ans : This medication is generally used twice or thrice a day, as the time interval to which this medication has an impact, is around 6 to 8 hours, but it is not the standard frequency, for using this medication. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Novaclav-625 Tablet empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken with the food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Novaclav-625 Tablet?

  Ans : This medication contains salts which are suitable to store between 20 to 25c temperature, as keeping this medication above or below that, can cause an inadequate effect. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, for avoiding its inadequate effect.

• AUGMENTIN- amoxicillin and clavulanate potassium tablet, film coated- Daily Med [Internet]. dailymed.nlm.nih.gov. 2016 [Cited 25 April 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=174cc098-fe49-4f1a-87e2-601c7573f0db

• Amoxicillin mixture with Clavulanate- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 24 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/amoxyclav

• Co amoxiclav:Uses, Side Effects, Mechanism,Dosage- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 24 April 2019]. Available from:

  https://www.drugsbanks.com/co-amoxiclav/

• Amoxicillin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 24 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/26787-78-0