Nuforce 150 MG Tablet

Nuforce 150 MG Tablet is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.

Nuforce 150 MG Tablet is indicated for oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-threatening Candida infections (eg, cystitis, esophagitis); treatment of hepatosplenic candidiasis and other Candida infections in persons unable to tolerate amphotericin B.

It is also prescribed for the treatment of cryptococcal infections; secondary prophylaxis for cryptococcal meningitis in persons with AIDS; antifungal prophylaxis in allogeneic bone marrow transplant recipients.

This medicine belongs to the class of triazole antifungal. Nuforce 150 MG Tablet is effectively used in the treatment of meningitis. It affects the membranes in the brain and spinal cord. This drug treats fungal infections like yeast infections in the mouth, throat, food pipe, lungs, vagina, etc.

It works by decreasing the production of ergosterol, which inhibits cell membrane formation in fungi. This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation.

Some serious side effects that may occur and need immediate medical attention are:

• Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage
• Severe rash or peeling of the skin in patients suffering from cancer or AIDS
• Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)

Symptoms of overdose include decreased lacrimation, salivation, respiration and motility, urinary incontinence, cyanosis. Treatment includes supportive measures, a 3-hour hemodialysis will remove 50%.

Take as directed, around-the-clock. Take full course of medication as ordered. Follow good hygiene measures to prevent reinfection. Frequent blood tests may be required. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

• Oropharyngeal Candidiasis

• Vaginal Candidiasis

• Fungal Infections (Tinea Strains)

• Cryptococcal Meningitis

• Coccidioidomycosis

• Hypersensitivity

• Nausea

• Headache

• Vomiting

• Skin Rash

• Hypokalemia

• Dizziness

• Decreased Appetite

• Insomnia

• Vertigo

• Abdominal Pain

• How long is the duration of effect?

  The action of Fluconazole in the body lasts for up to 30 hours are administration.

• What is the onset of action?

  Fluconazole starts is action within a couple of hours after oral use.

• Are there any pregnancy warnings?

  This drug is extremely unsafe to be used during pregnancy. Studies carried out on humans and animals have shown significant adverse effects on the fetus. Doctor consultation is recommended in such cases.

• Is it habit forming?

  It does not have addictive tendencies.

• Are there any breast-feeding warnings?

  The drug should not be consumed by breastfeeding mothers as there is a higher risk of side-effects on the infant. You are suggested to consult your doctor to discuss the potential benefits and risks before taking this medicine.

• Does this affect kidney function?

  Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Nuforce 150 MG Tablet. Dosing adjustment/interval in renal impairment:

  • No adjustment for vaginal candidiasis single-dose therapy.
  • For multiple dosing, administer usual load then adjust daily doses.
  • Clcr 11-50 mL/minute: Administer 50% of recommended dose or administer every 48 hours.
  • Hemodialysis: One dose after each dialysis.
  • Continuous arteriovenous or venovenous hemodiafiltration (CAVH) effects: Dose as for Clcr 10-50 mL/minute.

• Does this affect liver function?

  No relevant information available. Consult your doctor before taking this medicine.

• Is It safe with alcohol?

  Caution is advised in consuming alcohol, if you are taking this medicine. Please consult your doctor.

• Is it safe to drive while on this medicine?

  This medicine causes side effects that affect the alertness of the patients. Thus it influences the driving ability of the patient.

Below is the list of medicines, which have the same composition, strength and form as Nuforce 150 MG Tablet , and hence can be used as its substitute.

• Fungikem O 150 MG Tablet

  Alkem Laboratories Ltd

• Flucess 150 MG Tablet

  Novartis India Ltd

• Flukem 150 MG Tablet

  Alkem Laboratories Ltd

• Intawin 150 MG Tablet

  Intas Pharmaceuticals Ltd

• Flutas 150 MG Tablet

  Intas Pharmaceuticals Ltd

• Are there any missed dose instructions?

  Missed dose of Fluconazole may be taken later unless it is already time for the next dose.

• Are there any overdose instructions?

  Overdose of Fluconazole can worsen the side effects of using the medicine. You may need to seek medical help.

Nuforce 150 MG Tablet decreases ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Micosporum.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

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  Fluconazole does not interact with alcohol.

• Interaction with Lab Test

  Keep monitoring periodic liver function tests (AST, ALT, alkaline phosphatase) and renal function tests, potassium. As these might drastically be affected by the action of this medicine.

• Interaction with Medicine

  • Increased effect/toxicity:
  • Coadministration with terfenadine or cisapride is contraindicated; use with caution with astemizole due to increased risk of significant cardiotoxicity.
  • Hydrochlorothiazide may decrease fluconazole clearance.
  • Fluconazole may also inhibit warfarin, phenytoin, cyclosporine, and theophylline, zidovudine, sulfonylureas, rifabutin, and warfarin clearance.
  • Nephrotoxicity of tacrolimus may be increased.
  • Should be used with caution in patients receiving cisapride or astemizole.

• Interaction with Disease

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  Should be used with caution in patients with renal and hepatic dysfunction or previous hepatotoxicity from other azole derivatives. Patients who develop abnormal liver function tests during fluconazole therapy should be monitored closely and discontinued if symptoms consistent with liver disease develop.

• Interaction with Food

  null

  Fluconazole has no interaction with food.

• Ques : What is Nuforce 150 MG Tablet?

  Ans : Nuforce 150 MG Tablet is a medication which has Fluconazole as an active element present in it. This medicine performs its action by preventing the formation of ergosterol, which is necessary for the synthesis of the fungal cell wall. Nuforce 150 MG Tablet is used to treat conditions such as Oropharyngeal Candidiasis, Esophageal Candidiasis, Cryptococcal Meningitis, Vaginal Candidiasis, etc.

• Ques : What are the uses of Nuforce 150 MG Tablet?

  Ans : Nuforce 150 MG Tablet is a medication, which is used for the treatment and prevention from conditions such as Oropharyngeal Candidiasis, Esophageal Candidiasis, Cryptococcal Meningitis, Vaginal Candidiasis, and Urinary Tract Infection. Apart from these, it can also be used to treat conditions like Peritonitis, Candidemia, and Prophylaxis of Infections in Special Population. The patient should inform the doctor about any ongoing medications and treatment before using Nuforce 150 MG Tablet to avoid undesirable effects.

• Ques : What are the Side Effects of Nuforce 150 MG Tablet?

  Ans : Nuforce 150 MG Tablet is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Nuforce 150 MG Tablet which are as follows: Headache, Nausea and Vomiting, Abdominal pain, Diarrhea, Skin rash, QT Prolongation, Alopecia, Seizures, and Swelling of the face, lips, eyelids, tongue, hands, and feet. It is a list of possible side-effects which may occur due to the constituting ingredients of Nuforce 150 MG Tablet.

• Ques : What are the instructions for storage and disposal Nuforce 150 MG Tablet?

  Ans : Nuforce 150 MG Tablet should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

• Ques : Should I use Nuforce 150 MG Tablet empty stomach, before food or after food?

  Ans : You are free to take this medication either before or after having food. it will not create any hindrance in medication’s action, neither it will affect its effectiveness. The only advice is, take Nuforce Tablet at a particular time in a day.

• Ques : How long do I need to use Nuforce 150 MG Tablet before I see improvement of my conditions?

  Ans : The time taken by this medication to improve your health is unknown. Thus it is advised to use this medication for the time period it is prescribed by your doctor. Using this medication longer then its prescribed time may cause some side effects to the patient. Please consult your doctor before using Nuforce 150 Tablet.

• Ques : Is there any food or drink I need to avoid?

  Ans : You can follow your normal diet under the usage of this medication. Avoidance of any specific food product is not required. Though staying away from practices like drinking and smoking can improve your health.

• Ques : Will Nuforce 150 MG Tablet be more effective if taken in more than the recommended dose?

  Ans : Excess of usage of this medication can trigger side effects. The salts involved may cause inadequate effects to your health if Nuforce 150 mg Tablet is taken more than its prescribed dosage or taken more times then its prescribed frequency.

• Fluconazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/fluconazole

• Azocan-P Capsules 150mg- EMC [Internet]. www.medicines.org.uk. 2020 [Cited 23 Nov 2021]. Available from:

  https://www.medicines.org.uk/emc/product/4960/smpc

• FLUCONAZOLE tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2019 [Cited 23 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5590e3fc-b9a1-4863-9420-900bf437a3cc