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Overview

Pregamax Nt 75Mg/10Mg Tablet

Manufacturer :  Winmark Pharmaceuticals Pvt Ltd
Medicine Composition :  Pregabalin, Nortriptyline
Prescription vs OTC : Prescription by Doctor required

About Pregamax Nt 75Mg/10Mg Tablet

Pregamax Nt 75Mg/10Mg Tablet is a combination medication prescribed for the treatment of severe neuropathic pain. It is also used for the management of neuropathic disorders like diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.

It works by binding to a certain region of the brain and reducing the pain signals sent out by the damaged nerves of the body. This medicine is also utilised for treating restless leg syndrome, epilepsy, shingles, seizures, fibromyalgia and generalised anxiety disorder.

This medication is not recommended for you if you are pregnant, or have an allergic reaction towards any of its ingredients. Some medicines interact with it. Inform your doctor if you are taking any of the following:

  • Angiotensin- converting enzyme inhibitors
  • Benzodiazepines or narcotic pain medicines
  • Thiazolidinedione antidiabetic agents

Ensure your doctor is informed if you have any of the following medical conditions before starting the medication:

  • If you have congestive heart failure, irregular heartbeat, diabetes, bleeding problems, muscle problems, highballed pressure or low platelet count.
  • If you have improper kidney functioning or are on dialysis.
  • If you have a history of angioedema.
  • If you are pregnant, planning to be pregnant or are breastfeeding.
  • If you take any other medicines, dietary supplements or herbal preparations.
  • If you have mental or mood problems, suicidal thoughts, or are dealing with depression.

The dose for this medication may vary according to the age, sex, pathological conditions and other factors. The dosage can later be increased depending on efficacy and tolerability of the patient.

    What are the uses of Pregamax Nt 75Mg/10Mg Tablet

    • Neuropathic Pain

    • Diabetic Peripheral Neuropathy

    • Postherpetic Neuralgia

    What are the contraindications of Pregamax Nt 75Mg/10Mg Tablet ?

    • Hypersensitivity

    • Myocardial Infarction

    What are the side effects of Pregamax Nt 75Mg/10Mg Tablet ?

    Key highlights of Pregamax Nt 75Mg/10Mg Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 10-12 hours.

    • What is the onset of action?

      This medicine has a varying onset time depending on the intended use.

    • Are there any pregnancy warnings?

      Use of this medicine during pregnancy is not recommended unless absolutely necessary.

    • Is it habit forming?

      This medicine has a low abuse potential with limited physical and psychological dependence.

    • Are there any breast-feeding warnings?

      The use of this medicine by breastfeeding women is not recommended.

    What are the substitutes for Pregamax Nt 75Mg/10Mg Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Pregamax Nt 75Mg/10Mg Tablet , and hence can be used as its substitute.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

    • Are there any overdose instructions?

      Contact your doctor immediately if an overdose is suspected. Symptoms of overdose may include agitation, mental confusion, excessive drowsiness.

    How does this medication work?

    This medication is a combination of Pregabalin and Nortriptyline, thus work through dual mechanism of action. Primarily, it behaves as a GABA analogue and binds to the voltage-gated calcium channels in the central nervous system. This causes a reduced release of neurotransmitters like serotonin, dopamine, substance P thus slowing down nerve signals. Secondarily, it blocks the serotonin reuptake at the neuronal membrane. Also, it inhibits the reuptake of norepinephrine and raises its concentration in the synaptic cleft.

      What are the interactions of Pregamax Nt 75Mg/10Mg Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Ethanol

        Avoid or limit the use of alcohol while taking this medicine. One should refrain from operating heavy machinery or performing works that require a high level of mental alertness.
      • Interaction with Medicine

        Lorazepam

        Report the use of Lorazepam or any other medicine that you take for sleep disorders or anxiety problems. The risk of adverse effects like dizziness, drowsiness, confusion, lack of focus, etc., is very high while taking these medicines together. Special precaution is advised if these medicines are taken by an elderly person.

        Pioglitazone

        Report the use of Pregabalin to the doctor before receiving Pioglitazone or any other medicine used for controlling high blood sugar levels. These medicines could increase the risk of weight gain, fluid retention, and heart failure when taken together. You may need a dose adjustment and frequent monitoring to safely use these medicines together.

        Ramipril

        Report the use of Ramipril or any other medicine belonging to the class of ACE inhibitors used for lowering blood pressure. The risk of fluid retention and associated adverse effects on the heart are significantly increased when these medicines are used together.

        Oxycodone

        Report the use of any opiate pain medicines to the doctor before receiving Pregabalin. Using these medicines together can cause severe dizziness, confusion, lack of coordination especially in the elderly and people with a history of emotional disturbances, suicidal thoughts, alcohol abuse, or drug abuse. Any such effect while using them together should be reported to the doctor.
      • Interaction with Disease

        Angioedema

        This medicine should be administered with caution in patients who have a history of or are at risk of developing swellings of the inner layers of the skin. These swellings can cause airway blockage and prove life-threatening.
      • Interaction with Food

        Food

        Information not available.

      FAQs about Pregamax Nt 75Mg/10Mg Tablet

      • Ques : What is Pregamax Nt 75Mg/10Mg Tablet?

        Ans : This medication is a combination of Pregabalin and Nortriptyline and is considered to be the first-line of treatment for neurotic pain, shingles, seizures and fibromyalgia.

      • Ques : How long do I need to use Pregamax Nt 75Mg/10Mg Tablet before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Pregamax Nt 75Mg/10Mg Tablet?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : Should I use Pregamax Nt 75Mg/10Mg Tablet empty stomach, before food or after food?

        Ans : This medication should be taken after food in a prescribed dosage.

      • Ques : What are the instructions for the storage and disposal of Pregamax Nt 75Mg/10Mg Tablet?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Nortriptyline- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/pregabalin

      • Pregabalin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/nortriptyline

      • Nortriptyline 10 mg Film-coated Tablets [Internet]. medicines.org.uk 2019 [Cited 23 January 2020]. Available from:

        https://www.medicines.org.uk/emc/medicine/32962

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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