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Overview

Prostium ES Capsule

Banned
Manufacturer :  Pharmanova India Drugs Pvt Ltd
Medicine Composition :  Estradiol, Sildenafil
Prescription vs OTC : Prescription by Doctor required

About Prostium ES Capsule

Prostium ES Capsule is used for the treatment of atrophic vaginitis, atrophic dystrophy of vulva, menopausal symptoms, female hypogonadism, ovariectomy, primary ovarian failure, inoperable breast cancer, inoperable prostatic cancer, and mild to severe vasomotor symptoms associated with menopause.

Prostium ES Capsule (active constituent) is a type of estrogen, a sex hormone in women. It is produced by the follicles of the ovaries, adrenal glands and the placenta during the period of pregnancy. It has a number of functions and is the most important hormone in a female’s body.

Estradiol operates as the growth hormone for the reproductive organs such as cervical glands, the endometrium glands, the vagina, and the fallopian tubes. Prostium ES Capsule also functions in the maintenance of eggs in the ovary. This hormone also ensures the overall health of various other organs and tissues in your body. Although very low in men, this hormone can be found in most vertebrates. Prostium ES Capsule is produced by the Sertoli cells in the testes in Males.

Prostium ES Capsule is used in the treatment of menopausal symptoms such as hot flashes, night sweats, insomnia, burning sensation, irritability and frequent urination urges. It is sometimes also used in the treatment of cancer in both men and women.

You should not use Prostium ES Capsule if you are allergic to it or in case of any of these situations mentioned below if you have or are:

If not taken under proper supervision Prostium ES Capsule stands the risk of causing uterine cancer if you already suffer from vaginal bleeding. In case of vaginal bleeding inform your doctor right away. Prostium ES Capsule if taken when pregnant can cause harm to your fetus by way of birth defects. If taken in moderation and in the right conditions Prostium ES Capsule can significantly improve the quality of your well-being.

Use this drug in cycles or term as prescribed. Periodic gynecologic exam and breast exams are important. You may experience nausea or vomiting (small frequent meals may help); dizziness or mental depression (use caution when driving); photosensitivity (use sunscreen, wear protective clothing and eyewear, and avoid direct sunlight); rash; loss of scalp hair; enlargement/tenderness of breasts; increased/decreased libido.

Report sudden acute pain in legs or calves, chest, or abdomen; shortness of breath; severe headache or vomiting; weakness or numbness of arms or legs; unusual vaginal bleeding; yellowing of skin or eyes; change in color of urine or stool; or easy bruising or bleeding.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    What are the uses of Prostium ES Capsule

    • Hormone Replacement Therapy (Hrt)

    • Post Menopausal Osteoporosis

    • Contraception

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    What are the contraindications of Prostium ES Capsule ?

    • Allergy

      This medicine is not recommended for use in patients who have a known allergy to estrogen products or any other ingredient present along with it.

    • Undiagnosed Vaginal Bleeding

      This medicine is not recommended for use if you have an abnormal episode of vaginal bleeding which was not diagnosed.

    • Heart And Blood Vessel Disorder

      This medicine is not recommended for use in patients having a disease of the heart or blood vessels viz. deep vein thrombosis, recent heart attack, other blood clotting disorders etc.

    • Breast Cancer

      This medicine is not recommended for use in patients having breast cancer. It should also not be used if a patient has had breast cancer before or is suspected of having it. Patients having end stage breast cancer and on palliative care are an exception here.

    • Estrogen-Dependent Tumor

      This medicine is not recommended for use in patients having cancer which is attributed to abnormal levels of the hormone estrogen in the body for prolonged duration.

    • Liver Disease

      This medicine is not recommended for use in patients having an impairment of liver function owing to a disease or other contributing factors.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    What are the side effects of Prostium ES Capsule ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    Key highlights of Prostium ES Capsule

    • Is It safe with alcohol?

      Interaction with alcohol is unknown. Please consult your doctor.

    • Are there any pregnancy warnings?

      Prostium ES Capsule is highly unsafe to use during pregnancy.
      Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

    • Are there any breast-feeding warnings?

      Prostium ES Capsule is safe to use during lactation. \nHuman studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.

    • Is it safe to drive while on this medicine?

      Prostium ES Capsule does not usually affect your ability to drive.

    • Does this affect kidney function?

      Prostium ES Capsule should be used with caution in patients with kidney disease. Dose adjustment of Prostium ES Capsule may be needed. Please consult your doctor.

    • Does this affect liver function?

      Prostium ES Capsule should be used with caution in patients with liver disease. Dose adjustment of Prostium ES Capsule may be needed. Please consult your doctor. Use of Prostium ES Capsule is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    What are the substitutes for Prostium ES Capsule ?

    Below is the list of medicines, which have the same composition, strength and form as Prostium ES Capsule , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

    • Are there any overdose instructions?

      Contact your doctor if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, or vaginal bleeding.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    Where is the Prostium ES Capsule approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

    How does this medication work?

    Prostium ES Capsule is an estrogen that works by binding to and activating specific estrogen receptors throughout the body including Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). This activates the transcription of genes in the DNA for the regular functioning of the female reproductive system.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Laser Gynae before using this medicine.

      What are the interactions of Prostium ES Capsule ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Lab Test

        Doctor must be informed if you are taking this drug if you are about to get any of the following lab test to be done, as it may affect the test result as follows:
        • Decreased antithrombin III
        • Decreased serum folate concentration
        • Increased prothrombin and factors VII, VIII, IX, X
        • Increased platelet aggregability
        • Increased thyroid binding globulin
        • Increased total thyroid hormone (T4)
        • Increased serum triglycerides/phospholipids
      • Interaction with Medicine

        • CYP1A2 and 3A3/4 enzyme substrate.
        • Increased toxicity: Hydrocortisone increases corticosteroid toxic potential; increased potential for thromboembolic events with anticoagulants.
      • Interaction with Food

        Larger doses of vitamin C (eg, 1 g/day in adults) may increase serum concentrations and adverse effects of estradiol. Vitamin C supplements are not recommended, but their effect may be decreased if vitamin C supplement is administered 2-3 hours after estrogen. Dietary intake of folate and pyridoxine may need to be increased.
      • Interaction with Disease

        • Use with caution in patients with renal or hepatic insufficiency. Estrogens may cause premature closure of epiphyses in young individuals, in patients with a history of thromboembolism, stroke, myocardial infarction (especially >40 years of age who smoke), liver tumor, or hypertension.
        • Use vaginal tablets with caution in patients with severely atrophic vaginal mucosa or following gynecological surgery due to possible trauma from the applicator.
        • Estrogens have been reported to increase the risk of endometrial carcinoma; do not use estrogens during pregnancy. Before prescribing estrogen therapy to postmenopausal women, the risks and benefits must be weighed for each patient. Women should be informed of these risks and benefits, as well as possible side effects and the return of menstrual bleeding (when cycled with a progestin), and be involved in the decision to prescribe. Oral therapy may be more convenient for vaginal atrophy and stress incontinence.

      FAQs about Prostium ES Capsule

      • Ques : What is Prostium ES Capsule used for?

        Ans : Prostium ES Capsule is used in the treatment of menopausal symptoms such as hot flashes, night sweats, insomnia, burning sensation, irritability and frequent urination urges. It is sometimes also used in the treatment of cancer in both men and women.

      • Ques : What is the half-life of Prostium ES Capsule?

        Ans : The half-life of Prostium ES Capsule depends on the route of administration. The half-life of Prostium ES Capsule, when taken orally, is between 1 to 12 hours.

      • Ques : What is the onset of action of Prostium ES Capsule?

        Ans : The effect of Prostium ES Capsule takes about 14 to 30 days after oral administration.

      • Ques : What is the duration of the effect of Prostium ES Capsule?

        Ans : The effect of Prostium ES Capsule lasts between 7 to 12 days.

      • Ques : Is Prostium ES Capsule safe for usage in pediatrics?

        Ans : Prostium ES Capsule is not recommended for usage in pediatrics as its safety and effectiveness are not established.

      • Ques : What is the route of administration of Prostium ES Capsule?

        Ans : Prostium ES Capsule can be administered both orally and intravenously.

      References

      • Estradiol-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/estradiol

      • Estradiol-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 28 May 2022].Available from:

        https://go.drugbank.com/drugs/DB00783

      • Estradiol Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Estradiol

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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