Quinidine

Quinidine is helpful in treating the problem of irregular heartbeats and heart arrhythmias such as atrial fibrillation. It can be helpful by reducing the number of irregular heartbeats and by blocking abnormal heartbeat signals.

Your doctor may also prescribe certain other drugs in combination with these medicines like blood thinners, anticoagulants and beta-blockers. This is done to reduce any blood clots in the heart and to slow down the pulse rate.

Before using this medicine, please check whether you are allergic to it or any of its constituents. Consult your doctor before taking this medication. Inform the doctor about your medical history and allergies. It is advised to consume this drug with a glass full of water. The best way to take this drug is on an empty stomach.

The dose and duration of this drug is dependent on the patient’s medical condition. Hence, consult your doctor for details regarding dosage. Avoid the consumption of grapefruit juice during the course of medication as it can cause interference with the mechanism of medicine. The amount of salt you consult in your food can also change the amount of absorption of this drug. It is important to keep your doctor updated if your medical condition does not approve after this drug.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Atrial Fibrillation

• Arrhythmia

• Irregular Heart Beat

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Hypersensitivity

• Thrombocytopenia

• Prolong Qt Interval

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Severe Diarrhea

• Nausea Or Vomiting

• Loss Of Appetite

• Stomach Pain

• Heartburn

• Change In Vision

• Eye Pain

• Hypoglycaemia (Low Blood Sugar Level)

• Easy Bruising And Bleeding

• Excessive Tiredness

• Dark Urine

• Skin Yellowing

• Hypotension

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Are there any pregnancy warnings?

  Please consult your doctor and take all the necessary precautions as this drug is probably unsafe to be used during pregnancy.

• Are there any breast-feeding warnings?

  The drug can pass through milk, hence exercise caution if you are taking this medicine.

• Is it habit forming?

  No habit forming tendencies were reported.

• Does this affect kidney function?

  Please consult your doctor before taking this medication if you have kidney problems. Caution must be taken. Adjustment of dose is needed.

• Does this affect liver function?

  Please consult your doctor before taking this medication if you have liver problems. Adjustment of dose is needed. Larger loading dose may be indicated, reduce maintenance doses by 50% and monitor serum levels closely.

• How long is the duration of effect?

  The drug remain active for about 6 - 8 hours after its administration.

• What is the onset of action?

  The action of this drug is initiated within 60 minutes after its administration.

• Is it safe to drive while on this medicine?

  No information available

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Are there any overdose instructions?

  In case of an overdose, you may experience some side effects. Therefore, it is advised to take medical help immediately.

• Are there any missed dose instructions?

  It is advised to not to miss a dosage since there is just one dose per day. Consume the missed dosage as soon as you remember.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

Below is the list of medicines, which contains Quinidine as ingredient

• Dospin 150 Mg/75 Mg Tablet

  Ajanta Pharma Ltd

• Pidlet Plus 150 Mg/75 Mg Tablet

  Orchid Chemicals & Pharmaceuticals Ltd

• Rozucor Asp -10 Tablet

  Torrent Pharmaceuticals Ltd

• Mactor Asp Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Clopilet A 75 Capsule

  Sun Pharmaceutical Industries Ltd

• Jupiros A 75 Capsule

  Alkem Laboratories Ltd

• Rosycap-Gold 10/75 Tablet

  Akumentis Healthcare Ltd

• Razel Gold 20Mg Capsule

  Glenmark Pharmaceuticals Ltd

• Novastat Gold Tablet

  Lupin Ltd

• Ecorose 10 Capsule

  Alde Medi Impex Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

This medication works by decreasing myocardial excitability and conduction velocity, and myocardial contractility by decreasing sodium influx during depolarization and potassium efflux in repolarization It also depresses phase O of the action potential and lastly it also reduces calcium transport across the cell membrane.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  • Amiloride may cause prolonged ventricular conduction leading to arrhythmias.
  • Amiodarone may increase quinidine blood levels; monitor quinidine levels.
  • Cimetidine: Increase quinidine blood levels; closely monitor levels or use an alternative H2 antagonist.
  • Cisapride and quinidine may increase risk of malignant arrhythmias; concurrent use is contraindicated.
  • Codeine: Analgesic efficacy may be reduced.
  • Digoxin blood levels may be increased. Monitor digoxin blood levels.
  • Enzyme inducers (aminoglutethimide, carbamazepine, phenobarbital, phenytoin, primidone, rifabutin, rifampin) may decrease quinidine blood levels.
  • Metoprolol: Increased metoprolol blood levels.
  • Mexiletine blood levels may be increased.
  • Nifedipine blood levels may be increased by quinidine; nifedipine may decrease quinidine blood levels.
  • Drugs which prolong the QT interval include amiodarone, amitriptyline, astemizole, bepridil, disopyramide, erythromycin, haloperidol, imipramine, pimozide, procainamide, sotalol, and thioridazine. Effects may be additive; use with caution.
  • Propafenone blood levels may be increased.
  • Propranolol blood levels may be increased.
  • Ritonavir, nelfinavir and amprenavir may increase quinidine levels and toxicity; concurrent use is contraindicated.
  • Sparfloxacin, gatifloxacin, and moxifloxacin may result in additional prolongation of the QT interval; concurrent use is contraindicated.
  • Timolol blood levels may be increased.
  • Urinary alkalinizers (antacids, sodium bicarbonate, acetazolamide) increase quinidine blood levels.
  • Verapamil and diltiazem increase quinidine blood levels.
  • Warfarin effects may be increased by quinidine; monitor INR closely during addition or withdrawal of quinidine.

• Interaction with Food

  Excessive intake of fruit juices or vitamin C may decrease urine pH and result in increased clearance of quinidine with decreased serum concentration. Alkaline foods may result in increased quinidine serum concentrations. Food has a variable effect on the absorption of the sustained-release formulation.

• Interaction with Disease

  Monitor and adjust dose to prevent QTc prolongation. Watch for proarrhythmic effects. May precipitate or exacerbate CHF. Reduce dosage in hepatic impairment. In patients with atrial fibrillation or flutter, block the AV node before initiating. Correct hypokalemia before initiating therapy. Hypokalemia may worsen toxicity. Use may cause digoxin-induced toxicity (adjust digoxin's dose). Use caution with concurrent use of other antiarrhythmics. Avoid use in myasthenia gravis (may worsen condition). Can unmask sick sinus syndrome (causes bradycardia). Has been associated with severe hepatotoxic reactions, including granulomatous hepatitis. Hemolysis may occur in patients with G-6-PD (glucose-6-phosphate dehydrogenase) deficiency.

• Ques : Is it safe to take Quinidine before surgery?

  Ans : It is advised to not take Quinidine before surgery, and if it is taken notify your doctor. Quinidine may cause adverse effects and may interfere with surgical procedures.

• Ques : Is Quinidine safe for patients suffering from heart disease?

  Ans : Quinidine should be used with care in patients suffering from heart disorders as it may affect the heart rhythm and blood pumping capacity. Based on the disorder and condition, alternative medicine may also be considered.

• Ques : How is Quinidine administered?

  Ans : Quinidine is administered orally and its dosage depends on the age, condition, and medical history. Quinidine should be taken as directed.

• Ques : How is Quinidine stored and disposed of?

  Ans : Quinidine should be stored at room temperature in darkness, in its original packaging.

• Ques : Are regular checkups necessary while taking Quinidine?

  Ans : it is important to get regular checkups for kidney, liver, and heart function while taking Quinidine.

• Ques : What are the dietary instructions with Quinidine?

  Ans : It is advised to not consume grapes as it may delay the absorption of Quinidine. Additionally, do not change the salts in your diet while taking this medication without consulting your doctor first.

• Ques : What is the route of elimination of Quinidine?

  Ans : When the pH of the urine is below 7, 20% of the Quinidine is eliminated via the urine. This number goes down by 5% if the pH of the urine is above 7.

• Ques : What is the half-life of Quinidine?

  Ans : The half-life of Quinidine is between 6 to 8 hours.

• Aspirin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/aspirin

• Aspirin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 28 May 2022].Available from:

  https://go.drugbank.com/drugs/DB00945

• ASPIRIN capsule,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=ASPIRIN