Ramipril

Ramipril is an Angiotensin converting enzyme (ACE) inhibitor. Ramipril is used for the treatment of hypertension or high blood pressure. It is also given to patients who have suffered from heart attacks previously, to improve their condition.

It works by preventing the blood vessels from tightening. It relaxes the blood vessels. This lowers blood pressure and increases the oxygen and blood supply to the heart. It also prevents the narrowing of arteries and thus reduces the stress on heart muscles.

After a heart attack, the muscles might weaken. It makes the pumping of blood difficult for the heart. Ramipril ensures less train on heart muscles by normalizing blood pressure. The regular dose of Ramipril for a patient suffering from hypertension is 2.5 to 20 mg.

For a patient who has suffered from congestive heart attack, the dose amount is a 5mg tablet to be taken twice a day orally. It is important to follow the doctor’s prescription and continue the intake until he/she recommends not to. If you miss a dose, never try to compensate by overdosing as it is very dangerous.

While taking Ramipril, avoid alcohol as it might have an adverse effect on your blood pressure. To ensure that the intake of Ramipril is safe, if you have any kidney disease, liver disease,allergies or diabetes, mention it to your doctor.

Also it is dangerous for pregnant women to take this medication. So a pregnant women or someone who is trying to get pregnant should avoid Ramipril. It has a harmful effect on the development of the baby. Also, avoid breast feeding while using it.

If while using Ramipril, you suffer from vomiting or diarrhea, you should immediately consult a doctor. Some common side effects of Ramipril are dizziness, nausea, sweating or weariness . Some other side effects such as chest pain, jaw pain ,cloudy urine, cold sweat and shortness of breath.

Some of these side effects normally don’t require medical attention, but you can consult with your to doctor on how to reduce them. Ramipril should be stored at a cold temperature and should be kept out of the reach of children.

Take exactly as directed; do not discontinue without consulting prescriber. Take first dose at bedtime. This drug does not eliminate need for diet or exercise regimen as recommended by prescriber.

Do not take potassium supplements or salt substitutes containing potassium without consulting prescriber. May cause dizziness, fainting, lightheadedness (use caution when driving or engaging in tasks requiring alertness until response to drug is known).

Mild hypotension has been the only toxic effect seen with acute overdose. Bradycardia may also occur; mild hyperkalemia may occur even with therapeutic doses, especially in patients with renal insufficiency and those taking NSAIDs.

Following the initiation of essential overdose management, toxic symptom treatment and supportive treatment should be initiated. Hypotension usually responds to I.V. fluids or Trendelenburg positioning.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Hypertension

• Cardiovascular Risk Reduction

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Allergy

• Aliskiren

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Headache

• Dizziness

• Fatigue

• Vertigo

• Hypotension

• Syncope

• Hyperkalemia

• Vomiting

• Nausea

• Chest Pain

• Cough

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• How long is the duration of effect?

  This medicine is excreted in urine and faeces. The effect of this medicine lasts for a duration of 24 hours approximately.

• What is the onset of action?

  The peak effect of this medicine can be observed within 1 to 2 hours.

• Are there any pregnancy warnings?

  This medicine is not recommended for pregnant women.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for breastfeeding women.

• Is It safe with alcohol?

  Alcohol consumption must be avoided while taking this medicine.

• Is it safe to drive while on this medicine?

  This medicine might affect the consciousness of the patient taking this medicine. Driving must be avoided while taking this medicine.

• Does this affect kidney function?

  Caution must be taken while taking this medicine in patients with kidney disease. Adjustment of dose might be needed. Kindly consult your doctor before taking this medicine.

• Does this affect liver function?

  Caution must be taken while taking this medicine in patients with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Below is the list of medicines, which contains Ramipril as ingredient

• Ace Revelol 50/5 Tablet

  Ipca Laboratories Ltd

• Cardiopril 2.5 MG Capsule

  Dr. Reddys Laboratories Ltd

• Ramidil 2.5 MG Capsule

  Medley Pharmaceuticals

• Cardace 5 MG Tablet

  Sanofi India Ltd

• Cardace H 5 Tablet

  Sanofi India Ltd

• Ramistar 2.5 MG Capsule

  Lupin Ltd

• Cardiopril 10 MG Capsule

  Dr. Reddys Laboratories Ltd

• Artecure 5 MG Tablet

  Cure Quick Pharmaceuticals

• Cardace 2.5 MG Tablet

  Sanofi India Ltd

• Cardace 10 MG Tablet

  Sanofi India Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

This medicine works by inhibiting an enzyme called angiotensin-converting enzyme which results in decreased plasma angiotensin II and decreased aldosterone secretion. Thus prevents the blood vessel constriction, water reabsorption and helps in lowering the blood pressure.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  You should avoid the consumption of alcohol while taking this medicine as it may cause dizziness, headache, and changes in heart rate. Avoid driving or operating heavy machinery if you have these symptoms.

• Interaction with Lab Test

  Increases BUN, creatinine, potassium, positive Coombs' [direct]; decreases cholesterol (S); may cause false-positive results in urine acetone determinations using sodium nitroprusside reagent.

• Interaction with Medicine

  • Alpha1 blockers: Hypotensive effect increased.
  • Aspirin and NSAIDs may decrease ACE inhibitor efficacy and/or increase risk of adverse renal effects.
  • Diuretics: Hypovolemia due to diuretics may precipitate acute hypotensive events or acute renal failure.
  • Insulin: Risk of hypoglycemia may be increased.
  • Lithium: Risk of lithium toxicity may be increased; monitor lithium levels, especially the first 4 weeks of therapy.
  • Mercaptopurine: Risk of neutropenia may be increased.
  • Potassium-sparing diuretics (amiloride, spironolactone, triamterene): Increased risk of hyperkalemia.
  • Potassium supplements may increase the risk of hyperkalemia.
  • Trimethoprim (high dose) may increase the risk of hyperkalemia.

• Interaction with Food

  Food

  Information not available.

• Interaction with Disease

  • Angioedema can occur at any time during treatment (especially following first dose). Careful blood pressure monitoring with first dose (hypotension can occur especially in volume depleted patients).
  • Dosage adjustment needed in renal impairment. Use with caution in hypovolemia; collagen vascular diseases; valvular stenosis (particularly aortic stenosis); hyperkalemia; or before, during, or immediately after anesthesia.
  • Avoid rapid dosage escalation, which may lead to renal insufficiency.
  • Neutropenia/agranulocytosis with myeloid hyperplasia can rarely occur.
  • If patient has renal impairment then a baseline WBC with differential and serum creatinine should be evaluated and monitored closely during the first 3 months of therapy.
  • Hypersensitivity reactions may be seen during hemodialysis with high-flux dialysis membranes (eg, AN69).
  • Use with caution in unilateral renal artery stenosis and pre-existing renal insufficiency.

• Ques : What is Ramipril used for?

  Ans : Ramipril is used for the treatment of hypertension or high blood pressure.

• Ques : Should Ramipril be taken with a meal or without a meal?

  Ans : The effectiveness of Ramipril does not depend on a meal, it can be taken either way.

• Ques : Is Ramipril safe for usage in paediatrics?

  Ans : Ramipril is not recommended for usage in paediatrics as its safety and effectiveness are not known.

• Ques : Does Ramipril cause cough?

  Ans : Ramipril may cause cough in some patients, however, it is resolved when the medication is discontinued.

• Ques : What is the half-life of Ramipril?

  Ans : The half-life of Ramipril is between 13 to 17 hours, however, the half-life also depends upon the medicine dosage.

• Ques : How is Ramipril administered?

  Ans : Ramipril is administered orally with a glass of water.

• Ques : What are the storage indications of Ramipril?

  Ans : Ramipril should be stored between 15°C to 30°C away from direct heat and humidity.

• Ramipril-Drug Information portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 23 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/ramipril

• Ramipril-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 23 May 2022].Available from:

  https://go.drugbank.com/drugs/DB00178

• Ramipril Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 23 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=RAMIPRIL