Remdesivir

Remdesivir came under the spotlight due to its possible usage to treat critical cases of COVID-19 cases. As per the WHO officials, it is the only medicine that shows any significant effect as compared to other available options. It is one of the drugs in the WHO unanimity clinical trials. However, it's the only manufacturer, Gilead is also organising the same.

Indian drug-making companies recently received the approval for the Drug Controller-General of India (DCGI) approval to manufacture and sell the generic version of Gileads Remdesivir for COVID-19 treatment in the country. Remdesivir is available in the form of injectable.

Remdesivir belongs to the class of antiviral drugs. It was first manufactured to treat Ebola cases in 2014 by a US-based Biotechnology Company. It was also tried to treat MERS and SARS, both the diseases are caused by the coronavirus family and showed promising results back then.

Coronaviruses, in terms of genetic engineering, have single-strand RNA. When this novel coronavirus SARS-CoV2 enters a human cell, it starts to get replicated with the help of an enzyme called RdRP. Remdesivir works by inhibiting the activity of this enzyme.

Currently, it is approved to get manufactured and freely available in the market. About six clinical trials are being done globally for Remdesivir. These clinical trials focus more over critically ill patients with low oxygen levels and the patients which are with moderate symptoms.

The Indian Council of Medical Research (ICMR) has waited for the results of the WHO clinical trials to make an assessment on the efficacy of this drug to treat COVID-19. And now Remdesivir is available in India.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Severe Acute Respiratory Syndrome (SARS-CoV)

• Middle East Respiratory Syndrome (MERS-CoV)

• COVID-19

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Low Blood Pressure

• Nausea Or Vomiting

• Sweating

• Shivering

• Increased Liver Enzymes

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any pregnancy warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Does this affect kidney function?

  There is no data available. Please consult a doctor before consuming the drug.

• Does this affect liver function?

  Dose adjustment is needed in patients with liver disease. This drug is found to cause an increase in liver enzymes. You must consult your doctor before taking it.

• What is the onset of action?

  No relevant information available

• How long is the duration of effect?

  The drug remains active for a moderate time, as it is given only once daily.

• Is It safe with alcohol?

  No relevant information available.

• Is it safe to drive while on this medicine?

  No relevant information available.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any missed dose instructions?

  If you miss a dose of Remdesivir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which contains Remdesivir as ingredient

• Cipremi Injection

  Cipla

• Covifor Injection

  Hetro Drugs

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Remdesivir is an antiviral drug. Structurally, it is a nucleoside analogue that is expected to inhibit the action of RNA polymerase. This RNA polymerase helps the virus to replicate. This drug gets incorporated into the RNA, thus additional nucleotides cannot get added up. This leads to the termination of the RNA transcription process.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Remdesivir is still under trials, thus full information is yet to be identified.

• Interaction with Lab Test

  Remdesivir is still under trials, thus full information is yet to be identified.

• Interaction with Medicine

  Remdesivir is still under trials, thus full information is yet to be identified.

• Interaction with Food

  No interactions found.

• Interaction with Disease

  Remdesivir is still under trials, thus full information is yet to be identified.

• Ques : What is Remdesivir?

  Ans : Remdesivir is an antiviral drug. And recently received limelight due to its effectiveness in treating COVID-19 patients

• Ques : What is Remdesivir used for?

  Ans : It was primarily synthesized to treat Ebola cases. But recently received Indian regulatory approval for treating mild to moderate COVID-19 infected patients.

• Ques : What are the side effects of Remdesivir?

  Ans : The following are the side effects that might appear in a patient taking Remdesivir, that includes: low blood pressure, nausea/vomiting, sweating, shivering and increased liver enzymes.

• Ques : For how long should I continue Remdesivir?

  Ans : You must follow the prescription. Remdesivir must be taken for the period suggested by the doctor. It will depend on the severity of your condition.

• Ques : What are the instructions for storage and disposal of Remdesivir?

  Ans : This medication should be kept in a cool dry place and in its original pack. Make sure Remdesivir remains unreachable to children and pets. Proper disposal of the expired and unused medications is important to avoid health problems.

• Ques : How does Remdesivir work?

  Ans : Remdesivir worked by getting incorporated into the RNA, as structurally it is a nucleoside analogue. Thus it inhibits the action of RNA polymerase. No additional nucleotide get added up. This, in turns, leads to the termination of the RNA transcription process.

• Ques : What was Remdesivir originally used for?

  Ans : Remdesivir was first manufactured to treat Ebola cases. At that time, it was also clinically studied and results found that it can be used to treat MERS and SARS. That clinical study leads this medication to get more explored and finally received the approval to treat COVID-19 cases.

• Ques : Is Remdesivir approved in India?

  Ans : Yes, Remdesivir recently received DCGI approval for treating COVID-19 cases

• Ques : What is Remdesivir price?

  Ans : Remdesivir is available at the price or MRP of [covifor 100mg injection price in india] 5400 per vial.

• Remdesivir- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 22 June 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/remdesivir

• Remdesivir- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 22 June 2020]. Available from:

  https://www.drugbank.ca/drugs/DB14761

• Eastman RT, Roth JS, Brimacombe KR, Simeonov A, Shen M, Patnaik S, Hall MD. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19. ACS Central Science. 2020 May 27 [Cited 22 June 2020]. Available from:

  https://pubs.acs.org/doi/pdf/10.1021/acscentsci.0c00489