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Overview

Terlipressin

Prescription vs OTC : Prescription by Doctor required

About Terlipressin

Terlipressin is used to treat patients with low blood pressure levels, bleeding esophageal varices, hepatorenal syndrome, and septic shock. It works the same way as vasopressin does, and is its analog.

This medication regulates the amount of water retained in the body by increasing the amount of water absorbed by the kidney. It is found to be very much effective in cases where norepinephrine does not seem to work.

You should avoid taking this medicine if you are allergic to any of its components, if you have had chronic renal inflammation and if you have a medical history of heart ailments. This medicine could pose a risk to a fetus, and should not be used by pregnant women.

This medicine is administered intravenously, by means of injection. The initial recommended dosage for adults is 2 mg, followed by 1 or 2 mg every 4 to 6 hours, up to 72 hours, or until the bleeding of the varices stops. This medicine may cause chest pain, abdominal cramps, arrhythmia, and increased arterial pressure.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the uses of Terlipressin

    • Carcinoid Tumours And Bleeding Esophageal Varices

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the contraindications of Terlipressin ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the side effects of Terlipressin ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    Key highlights of Terlipressin

    • Is It safe with alcohol?

      Interaction with alcohol is unknown. Please consult your doctor.

    • Are there any pregnancy warnings?

      This medication is highly unsafe to use during pregnancy.

    • Are there any breast-feeding warnings?

      This medication is probably unsafe to use during breastfeeding. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      There is no data available. Please consult a doctor before consuming the drug.

    • Does this affect kidney function?

      There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

    • Does this affect liver function?

      There is no data available. Please consult a doctor before consuming the drug.

    • What is the onset of action?

      This medication initiates its action in the first 5 minutes after its administration.

    • How long is the duration of effect?

      The time for which this medication remain active and produces its action will vary patient to patient. It may range from 40 -180 minutes.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      If you miss a dose of this medication, skip it and continue with your normal schedule. Do not double the dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    Medicines containing Terlipressin

    Below is the list of medicines, which contains Terlipressin as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

    How does this medication work?

    This medication forms an analogue of an antidiuretic hormone (ADH) known as vasopressin acts on three separate receptors; vasopressin receptor V1b, vasopressin V1a receptor and vasopressin receptor V2 which plays part in controlling reabsorption of free water within the renal medullary.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

      What are the interactions of Terlipressin ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        Concomitant use of the following drugs must be avoided- propofol, sufentanil, lass IA and III antiarrhythmics, erythromycin, certain antihistamines, tricyclic antidepressants, some diuretics, and β-blockers.

      FAQs about Terlipressin

      • Ques : What is Terlipressin?

        Ans : This is a salt which performs its action by narrowing the blood vessels and reducing the blood flow into the affected veins. This helps to stop or slow the bleeding. It is used to treat conditions such as bleeding esophageal varices.

      • Ques : What are the uses of Terlipressin?

        Ans : This salt is used for the treatment and prevention of conditions such as Bleeding in the food pipe and Dilated blood vessels in the esophagus or stomach.

      • Ques : What are the Side Effects of Terlipressin?

        Ans : The side effects of Terlipressin are as follows Abdominal cramps, Insufficient supply of oxygen to heart, Paleness, Headache, Loss of breath rhythm, Shortening of breath, and Diarrhea.

      • Ques : What are the instructions for storage and disposal Terlipressin?

        Ans : Store Terlipressin in a cool dry place and keep it in the original pack or container until it is time to take them. Store this medication out of sight and reach of children.

      • Ques : How long do I need to use Terlipressin before I see improvement of my conditions?

        Ans : This is a medicine that takes 1 or 2 days before you see an improvement in your health conditions.

      • Ques : Will Terlipressin be more effective if taken in more than the recommended dose?

        Ans : No, taking higher than the recommended dose of Terlipressin can lead to increased chances of side effects such as Abdominal cramps, Insufficient supply of oxygen to the heart, Paleness, Headache, and Loss of breath rhythm.

      References

      • Terlipressin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 6 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/terlipressin

      • Terlipressin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 6 December 2019]. Available from:

        https://www.drugbank.ca/drugs/DB02638

      • Variquel 1mg powder and solvent for solution for injection- EMC [Internet] medicines.org.uk. 2017 [Cited 6 December 2019]. Available from:

        https://www.medicines.org.uk/emc/product/6583/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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