Topra D 10 Mg/20 Mg Tablet

This medication is indicated for treating GERD (Gastro-esophageal reflux disease), which does not respond to Pantoprazole medications alone. It prevents the tendency of vomiting and nausea in people suffering from gastrointestinal problems.

Topra D 10 Mg/20 Mg Tablet is a combination of Domperidone and Pantoprazole. The active ingredients fall under the class of dopamine antagonist and PPI (Proton pump inhibitor), respectively.

It is also prescribed to the patients of peptic ulcer and who take certain medicines for Parkinson’s disease. The medicine tightens the muscles near the entrance of the stomach and relaxes the ones present at the exit.

The action of this medication helps to speed up the passing of the food that you intake - from your stomach to your intestine, reducing the feeling of nausea and sickness, also preventing vomiting.

This medicine also works by blocking or reducing the stimulation in the ‘vomiting centre’ of your brain, which will eventually reduce the feeling of nausea and vomiting. The possible side effects of taking this medication can be headache, migraine, dryness of the mouth or breast pain.

You are advised not to take Topra D 10 Mg/20 Mg Tablet if you have the following conditions:

• An allergy to Topra D 10 Mg/20 Mg Tablet or any other ingredient of this medicine
• Bleeding problems or blockage in your stomach or in the intestine
• Tumour in the pituitary gland
• Cardiac disease
• Incorrect levels of magnesium, potassium or calcium in the blood
• Severe/moderate liver impairment

• Gastroesophageal Reflux Disease

• Peptic Ulcer

• Allergy

  Domperidone is not recommended for use in people having a known history of allergy to it.

• Tumor Of Pituitary Gland

  Domperidone is not recommended for use in people having tumor of the pituitary gland.

• Heart Diseases

  Domperidone is not recommended for use in people having an active heart disease like Congestive Heart Failure.

• Skin Rash

• Diarrhoea

• Headache

• Stomach Pain

• Dizziness

• Weakness

• Dry Mouth

• Cough

• Rhinitis

• Flatulence

• Insomnia

• How long is the duration of effect?

  The effect of this medicine lasts up to 6 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 30 to 60 minutes of administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for use in pregnant women unless the potential benefits outweigh the risks involved. The effect of this medicine on the fetus is not clearly established and hence you are advised to consult a doctor before taking this medicine.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for use by breastfeeding mothers as there is a risk of side effects on the infant. You are advised to consult your doctors and consider the potential benefit and risks before consuming this medication.

Below is the list of medicines, which have the same composition, strength and form as Topra D 10 Mg/20 Mg Tablet , and hence can be used as its substitute.

• Nupenta-D Capsule

  Macleods Pharmaceuticals Pvt Ltd

• Pancruz D 10Mg/20Mg Capsule

  Biorex Healthcare Pvt Ltd

• Perfekt D 10 Mg/20 Mg Tablet

  Ozone Pharmaceuticals Ltd

• Ulpan D 10 Mg/20 Mg Tablet

  Corona Remedies Pvt Ltd

• Pansa-D Tablet

  Zuventus Healthcare Ltd

• Forpan-Dm Tablet

  Foregen Healthcare Ltd

• Dompan Tablet

  Medley Pharmaceuticals

• Cocid-D Capsule

  Talent India

• Domtac Tablet

  Rapross Pharmaceuticals Pvt Ltd

• Ppz-D Tablet

  Rizer Healthcare Pvt Ltd

• Are there any missed dose instructions?

  Skip the missed dose and resume with the next scheduled dose at the right time. The dose should not get doubled in an attempt to make up for the missed dose.

• Are there any overdose instructions?

  Contact your doctor if an overdose is suspected. Symptoms of overdose may include drowsiness, agitation, and convulsions and may be more prevalent in infants and children. Immediate medical attention including gastric lavage may be required in severe cases.

This medication attaches to the dopaminergic receptors without causing any release of the chemical dopamine. It, in turn, facilitates gastric emptying and decreases small bowel transit time. Also, it binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Lab

  The patients taking this medicine have been reported for false results, as it interacts with investigations of Neuroendocrine Tumors, Secretin Stimulation Test, Urine Tests for THC. Thus an alternative confirmatory test should be considered to verify the results.

• Interaction with Medicine

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  Concomitant use of Antiretrovirals, warfarin, methotrexate, digoxin, Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole), tacrolimus, antiarrhythmics, apomorphine, protease inhibitors, systemic azole antifungals, some macrolides (erythromycin, clarithromycin and telithromycin) is contraindicated.

• Interaction with Disease

  Kidney Disease

  Topra D 10 Mg/20 Mg Tablet should be used with caution if you are suffering from impaired kidney function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is severe.

  Liver Disease

  Topra D 10 Mg/20 Mg Tablet should be used with caution if you are suffering from impaired liver function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is mild to moderate. For severe impairment, use of this medicine is not recommended.

  Intestinal Disorders

  Topra D 10 Mg/20 Mg Tablet should be used with extreme caution in people having serious intestinal problems like internal bleeding, an obstruction or perforation of the stomach and intestine. Use of an alternate medicine is advised in such cases.

• Interaction with Food

  Food

  Information not available.

• Ques : What is Topra D 10 Mg/20 Mg Tablet used for?

  Ans : This medication is used for causes mentioned below:

  • GRD (gastroesophageal reflux disease)
  • Erosive esophagitis
  • Gastro-duodenal ulcers
  • Zollinger-ellison syndrome

• Ques : Is Topra D 10 Mg/20 Mg Tablet safe during pregnancy?

  Ans : This active ingredient of this medication belongs to a medicine group called Dopamine antagonist (domperidone). The active ingredient of this medication belongs to a medicine group called PPI (Pantoprazole) and Dopamine antagonist (Domperidone). It never shown any risk to the baby, as there are no studies or human experiments data is available on it, which establish or proves any risk to the baby. Although, this medication is considered safe to consume during pregnancy. any risk to the baby, as there are no studies or human experiments data is available on it, which establish or proves any risk to the baby. Although, this medication is considered safe to consume during pregnancy.

• Ques : What is the best time of day to take Topra D 10 Mg/20 Mg Tablet?

  Ans : The best time to take this medication is to consume it empty stomach or before the first meal. But it is not adequate for the patients who have known allergies to Topra D 10 Mg/20 Mg Tablet or other medication of the same group.

• Ques : Is Topra D 10 Mg/20 Mg Tablet safe while breastfeeding?

  Ans : This medicine is not adequate for the use of breastfeeding unless it’s extremely necessary. Consult your doctor about all the risks and benefits before consuming this medication.

• Ques : How long do I need to use Topra D 10 Mg/20 Mg Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Topra D 10 Mg/20 Mg Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : What are the instructions for the storage and disposal of Topra D 10 Mg/20 Mg Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 27 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/domperidone

• Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 27 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01184

• Pantoprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 27 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/pantoprazole

• Pantoprazole- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 27 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00213