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Overview

Toprazole D 40 Mg/30 Mg Tablet Sr

Manufacturer :  Karnataka Antibiotics & Pharmaceuticals Ltd
Medicine Composition :  Domperidone, Pantoprazole
Prescription vs OTC : Prescription by Doctor required

About Toprazole D 40 Mg/30 Mg Tablet Sr

This medication is indicated for treating GERD (Gastro-esophageal reflux disease), which does not respond to Pantoprazole medications alone. It prevents the tendency of vomiting and nausea in people suffering from gastrointestinal problems.

Toprazole D 40 Mg/30 Mg Tablet Sr is a combination of Domperidone and Pantoprazole. The active ingredients fall under the class of dopamine antagonist and PPI (Proton pump inhibitor), respectively.

It is also prescribed to the patients of peptic ulcer and who take certain medicines for Parkinson’s disease. The medicine tightens the muscles near the entrance of the stomach and relaxes the ones present at the exit.

The action of this medication helps to speed up the passing of the food that you intake - from your stomach to your intestine, reducing the feeling of nausea and sickness, also preventing vomiting.

This medicine also works by blocking or reducing the stimulation in the ‘vomiting centre’ of your brain, which will eventually reduce the feeling of nausea and vomiting. The possible side effects of taking this medication can be headache, migraine, dryness of the mouth or breast pain.

You are advised not to take Toprazole D 40 Mg/30 Mg Tablet Sr if you have the following conditions:

  • An allergy to Toprazole D 40 Mg/30 Mg Tablet Sr or any other ingredient of this medicine
  • Bleeding problems or blockage in your stomach or in the intestine
  • Tumour in the pituitary gland
  • Cardiac disease
  • Incorrect levels of magnesium, potassium or calcium in the blood
  • Severe/moderate liver impairment

    What are the uses of Toprazole D 40 Mg/30 Mg Tablet Sr

    • Gastroesophageal Reflux Disease

    • Peptic Ulcer

    What are the contraindications of Toprazole D 40 Mg/30 Mg Tablet Sr ?

    • Allergy

      Domperidone is not recommended for use in people having a known history of allergy to it.

    • Tumor Of Pituitary Gland

      Domperidone is not recommended for use in people having tumor of the pituitary gland.

    • Heart Diseases

      Domperidone is not recommended for use in people having an active heart disease like Congestive Heart Failure.

    What are the side effects of Toprazole D 40 Mg/30 Mg Tablet Sr ?

    Key highlights of Toprazole D 40 Mg/30 Mg Tablet Sr

    • How long is the duration of effect?

      The effect of this medicine lasts up to 6 hours.

    • What is the onset of action?

      The peak effect of this medicine can be observed within 30 to 60 minutes of administration.

    • Are there any pregnancy warnings?

      This medicine is not recommended for use in pregnant women unless the potential benefits outweigh the risks involved. The effect of this medicine on the fetus is not clearly established and hence you are advised to consult a doctor before taking this medicine.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is not recommended for use by breastfeeding mothers as there is a risk of side effects on the infant. You are advised to consult your doctors and consider the potential benefit and risks before consuming this medication.

    What are the substitutes for Toprazole D 40 Mg/30 Mg Tablet Sr ?

    Below is the list of medicines, which have the same composition, strength and form as Toprazole D 40 Mg/30 Mg Tablet Sr , and hence can be used as its substitute.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      Skip the missed dose and resume with the next scheduled dose at the right time. The dose should not get doubled in an attempt to make up for the missed dose.

    • Are there any overdose instructions?

      Contact your doctor if an overdose is suspected. Symptoms of overdose may include drowsiness, agitation, and convulsions and may be more prevalent in infants and children. Immediate medical attention including gastric lavage may be required in severe cases.

    How does this medication work?

    This medication attaches to the dopaminergic receptors without causing any release of the chemical dopamine. It, in turn, facilitates gastric emptying and decreases small bowel transit time. Also, it binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

      What are the interactions of Toprazole D 40 Mg/30 Mg Tablet Sr ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Lab

        The patients taking this medicine have been reported for false results, as it interacts with investigations of Neuroendocrine Tumors, Secretin Stimulation Test, Urine Tests for THC. Thus an alternative confirmatory test should be considered to verify the results.
      • Interaction with Medicine

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        Concomitant use of Antiretrovirals, warfarin, methotrexate, digoxin, Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole), tacrolimus, antiarrhythmics, apomorphine, protease inhibitors, systemic azole antifungals, some macrolides (erythromycin, clarithromycin and telithromycin) is contraindicated.
      • Interaction with Disease

        Kidney Disease

        Toprazole D 40 Mg/30 Mg Tablet Sr should be used with caution if you are suffering from impaired kidney function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is severe.

        Liver Disease

        Toprazole D 40 Mg/30 Mg Tablet Sr should be used with caution if you are suffering from impaired liver function. Suitable dose adjustment and safety monitoring is advised, especially if the impairment is mild to moderate. For severe impairment, use of this medicine is not recommended.

        Intestinal Disorders

        Toprazole D 40 Mg/30 Mg Tablet Sr should be used with extreme caution in people having serious intestinal problems like internal bleeding, an obstruction or perforation of the stomach and intestine. Use of an alternate medicine is advised in such cases.
      • Interaction with Food

        Food

        Information not available.

      FAQs about Toprazole D 40 Mg/30 Mg Tablet Sr

      • Ques : What is Toprazole D 40 Mg/30 Mg Tablet Sr used for?

        Ans : This medication is used for causes mentioned below:

        • GRD (gastroesophageal reflux disease)
        • Erosive esophagitis
        • Gastro-duodenal ulcers
        • Zollinger-ellison syndrome

      • Ques : Is Toprazole D 40 Mg/30 Mg Tablet Sr safe during pregnancy?

        Ans : This active ingredient of this medication belongs to a medicine group called Dopamine antagonist (domperidone). The active ingredient of this medication belongs to a medicine group called PPI (Pantoprazole) and Dopamine antagonist (Domperidone). It never shown any risk to the baby, as there are no studies or human experiments data is available on it, which establish or proves any risk to the baby. Although, this medication is considered safe to consume during pregnancy. any risk to the baby, as there are no studies or human experiments data is available on it, which establish or proves any risk to the baby. Although, this medication is considered safe to consume during pregnancy.

      • Ques : What is the best time of day to take Toprazole D 40 Mg/30 Mg Tablet Sr?

        Ans : The best time to take this medication is to consume it empty stomach or before the first meal. But it is not adequate for the patients who have known allergies to Toprazole D 40 Mg/30 Mg Tablet Sr or other medication of the same group.

      • Ques : Is Toprazole D 40 Mg/30 Mg Tablet Sr safe while breastfeeding?

        Ans : This medicine is not adequate for the use of breastfeeding unless it’s extremely necessary. Consult your doctor about all the risks and benefits before consuming this medication.

      • Ques : How long do I need to use Toprazole D 40 Mg/30 Mg Tablet Sr before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Toprazole D 40 Mg/30 Mg Tablet Sr?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : What are the instructions for the storage and disposal of Toprazole D 40 Mg/30 Mg Tablet Sr?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 27 February 2020]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/domperidone

      • Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 27 February 2020]. Available from:

        https://www.drugbank.ca/drugs/DB01184

      • Pantoprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 27 February 2020]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/pantoprazole

      • Pantoprazole- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 27 February 2020]. Available from:

        https://www.drugbank.ca/drugs/DB00213

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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