TP 4000mg/500mg Injection

TP 4000mg/500mg Injection is used for the treatment of several serious bacterial infections and belongs to the category of an antibacterial agent. It also helps in preventing infections during surgery. This medicine works by blocking the growth of the bacterial cell wall, which eventually kills the bacteria.

This medicine is prescribed for the treatment of susceptible infections such as septicemia, acute and chronic respiratory tract infections, skin and soft tissue infections, and urinary tract infections due to susceptible strains of Pseudomonas, Proteus, and Escherichia coli and Enterobacter; active against some streptococci and some anaerobic bacteria.

This medication is not recommended for people allergic to penicillin or cephalosporin drug. Avoid using it if you are taking a tetracycline antibiotic. Some medications may interact with it so inform your doctor if you are taking any other medicines.

Consult your doctor before taking the medicine if you are:

• pregnant
• planning to become pregnant
• breast-feeding
• cystic fibrosis
• bleeding problems
• bowel inflammation
• congestive heart failure
• kidney problems

Symptoms of penicillin overdose include neuromuscular hypersensitivity (agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures) and electrolyte imbalance with potassium or sodium salts, especially in renal failure.

Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise, most treatment is supportive or symptom directed. This medicine is not absorbed orally, and must be given through intramuscular or intravenous injection by a healthcare professional.

If being treated for sexually transmitted disease, partner will also need to be treated. Small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may reduce nausea or dry mouth.

Important to maintain good oral and vaginal hygiene to reduce incidence of opportunistic infection. Diabetics should use serum glucose testing while on this medication. If diabetic, drug may cause false tests with Clinitest® urine glucose monitoring; use of glucose oxidase methods (Clinistix®) or serum glucose monitoring is preferable.

This drug may interfere with oral contraceptives; an alternate form of birth control should be used. Report persistent diarrhoea, fever, chills, unhealed sores, bloody urine or stool, muscle pain, mouth sores, or difficulty breathing.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Bacterial Infections

• Bacterial Septicemia

• Respiratory Tract Infection

• Skin And Soft Tissue Infections

• Urinary Tract Infection

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Convulsions

• Confusion

• Drowsiness

• Fever

• Rash

• Electrolyte Imbalance

• Thrombophlebitis

• Anaphylaxis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  This medication is probably safe to use during pregnancy.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Does this affect kidney function?

  Caution should be used in patients with renal impairment.
  Caution to be advised in patients with impaired renal function.

• Does this affect liver function?

  There is no data available. Please consult a doctor before consuming the drug.

• What is the onset of action?

  The effect is produced within 5 - 10 minutes of medicine administration.

• How long is the duration of effect?

  The duration varies person to person. It might be observed for 6 to 12 hours.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• Are there any missed dose instructions?

  If you miss a dose of this medication, please consult your doctor.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medication works as an antibacterial drug that is injected intravenously or intramuscularly to prevent bacterial infection. It kills the bacteria by preventing them from forming their cell walls by binding with certain penicillin binding proteins present in the bacterial cells.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Lab Test

  May interfere with urinary glucose tests using cupric sulfate (Benedict's solution, Clinitest®); may inactivate aminoglycosides in vitro; false-positive urinary and serum proteins, positive Coombs' test [direct]

• Interaction with Medicine

  • Decreased effect: Tetracyclines may decrease penicillin effectiveness; aminoglycosides physical inactivation of aminoglycosides in the presence of high concentrations of piperacillin and potential toxicity in patients with mild to moderate renal dysfunction; decreased efficacy of oral contraceptives is possible.
  • Increased effect:
    • Probenecid may increase penicillin levels.
    • Neuromuscular blockers may increase duration of blockade.
    • Aminoglycosides synergistic efficacy.
    • Heparin with high-dose parenteral penicillins may result in increased risk of bleeding.

• Interaction with Disease

  This medication interacts with the following disease: GI disturbances, rash, headache, dizziness, fatigue, seizures, renal impairment, anaphylaxis, blood dyscrasias, and bleeding. Dosage modification required in patients with impaired renal function; history of seizure activity; use with caution in patients with a history of beta-lactam allergy

• Ques : What is TP 4000mg/500mg Injection?

  Ans : This medication being an anti-bacterial agent, is used for treating several serious bacterial infections. It may also be used to prevent infections during surgery.

• Ques : How long do I need to use TP 4000mg/500mg Injection before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use TP 4000mg/500mg Injection?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use TP 4000mg/500mg Injection empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of TP 4000mg/500mg Injection?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : Can TP 4000mg/500mg Injection cause allergic reaction?

  Ans : Although it is rare but yes, TP 4000mg/500mg Injection can cause allergic reaction and is harmful in patients with known allergy to penicillins. Get emergency medical help if you have any of the signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

• Piperacillin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 5 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/61477-96-1

• Piperacillin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 5 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00319

• Piperacillin- Integrative Medicine, Syrian Clinic [Internet]. syrianclinic.com 2000 [Cited 5 December 2019]. Available from:

  https://www.syrianclinic.com/med/en/ProfDrugs/Piperacillinpd.html