Tranexamic Acid

Tranexamic Acid is prescribed to stop heavy bleeding. It works as an antifibrinolytic and thus stops the blood clots from disintegrating very fast, which in turn reduces bleeding.

It is prescribed for short-term use (2 - 8 days) in hemophilia patients, during and following tooth extraction. This helps in the reduction or prevention of haemorrhage. It is also used as an alternative to aminocaproic acid for subarachnoid hemorrhage (SAH).

Patients are generally discouraged from taking Tranexamic Acid if they have/are:

• Allergic to any component present in the drug
• A problem of blood clots that are present in the brain, eye, or lungs.
• Bleeding because of a kidney problem or brain problem.
• Experience irregular bleeding but its reason has not yet been determined
• Currently on birth control, like the pill or even the vaginal ring. This is primarily because such birth controls contains estrogen as well as progestin.

Before you start Tranexamic Acid provide your doctor a detailed medical history of your current health condition. Do not forget to inform him about any allergies you have or conditions like kidney problems and issues with vision. Also inform him if you are with pregnant or planning to conceive in the near future.

Tranexamic Acid should be taken as per the directions given by your doctor. The drug is meant for oral consumption and can be taken before or with a meal. It is best that you swallow the drug whole with the help of water or any other liquid. Avoid crushing or chewing the tablet as your body will not be able to absorb it properly. The drug should only be taken after the start of a menstrual period.

Taking medicines result in some side effects, but most people may not experience any or if they do, the side effects are very minor. Tranexamic Acid can lead to some side effects like- headache, pain in the joints, spasms, onset of sinus congestion, tiredness and pain in the stomach.

Some severe side effects that can result when you take Tranexamic Acid includes allergic reaction, seizures, dizziness and changes in vision. If you experience a major side effect get in touch with your health care provider as soon as possible.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Short-Term Management Of Hemorrhage

• Subarachnoid Hemorrhage

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Allergy

  This medicine is not recommended for use in patients who have a known history of allergy to tranexamic acid or any other ingredient present in the dosage form.

• Acquired Defective Color Vision

  This medicine is not recommended for use in people having a defective color vision as it could make toxicity determination very difficult.

• Subarachnoid Hemorrhage

  This medicine is not recommended for use in people who have hemorrhage in the area between the brain and its outer covering.

• Obstructive Blood Clotting Disorder

  This medicine is not recommended for use in patients having clotting disorders of the heart and blood vessels. The clots may also move from the place of origin and lodge in other locations. It is not recommended for people having the disease in the past or who are at risk of getting it in the future.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Nausea

• Diarrhoea

• Vomiting

• Hypotension

• Deep Vein Thrombosis

• Blurred Vision

• Menstrual Abnormalities

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 2-10 hours.

• What is the onset of action?

  The effect of this medicine can be observed within 10-30 minutes of intravenous administration. Time taken for the effect to show may increase with other dosage forms.

• Are there any pregnancy warnings?

  Use of this medicine by pregnant women is not recommended unless absolutely necessary. The benefits of medication along with associated risks should be considered before using it. Consult your doctor before taking this medicine.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine can be used by women who are breastfeeding as the risk of adverse effects of nursing infants are less. Consult your doctor before taking this medicine.

• Does this affect kidney function?

  Dosing adjustment/interval in renal impairment:

  • Clcr 50-80 mL/minute: Administer 50% of normal dose or 10 mg/kg twice daily I.V. or 15 mg/kg twice daily orally.
  • Clcr 10-50 mL/minute: Administer 25% of normal dose or 10 mg/kg/day I.V. or 15 mg/kg/day orally.
  • Clcr <10 mL/minute: Administer 10% of normal dose or 10 mg/kg/dose every 48 hours I.V. or 15 mg/kg/dose every 48 hours orally.

  Consult your before taking Tranexamic Acid.

• Does this affect liver function?

  No relevant data available. Consult your doctor before taking Tranexamic Acid.

• Is It safe with alcohol?

  It is found to be unsafe to consume alcohol along with this medicine.

• Is it safe to drive while on this medicine?

  This medicine usually does not affect the consciousness of the patient. Thus patient can drive while taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• Missed Dose instructions

  Take the missed dose as soon as you remember given that the next scheduled dose is at least 6 hours away. If you missed a scheduled injection of this medicine, then contact your doctor for further instructions.

• Are there any overdose instructions?

  Contact a doctor immediately if an overdose with tranexamic acid is suspected.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Below is the list of medicines, which contains Tranexamic Acid as ingredient

• Tenacid 500Mg/5Ml Injection

  Leeford Healthcare Ltd

• Cosklot Plus 250 Mg/250 Mg Tablet

  Adcock Ingram Healthcare Pvt Ltd

• Pause 500 MG Tablet

  Emcure Pharmaceuticals Ltd

• Xamic 500 MG Tablet

  Torrent Pharmaceuticals Ltd

• Pause-Mf 500 Mg/250 Mg Tablet

  Emcure Pharmaceuticals Ltd

• Derma Radia Tablet

  Veritaz Healthcare Ltd

• Trapic 650 MG Tablet

  Sun Pharma Laboratories Ltd

• Melano-Tx Od 500Mg Tablet

  La Pristine Bioceuticals Pvt Ltd

• Ethasyl T 500 Mg/250 Mg Tablet

  FDC Ltd

• Xamic Mf Tablet

  Torrent Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

This medication works by acting on enzyme plasmin which is primarily responsible for the dissolution of clots. It binds to the plasmin receptors and preserves the clot formed. It forms a reversible complex that displaces plasminogen from fibrin resulting in inhibition of fibrinolysis; it also inhibits the proteolytic activity of plasmin

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  Tamoxifen

  Report the use of either of the medicine to the doctor. Since the risk of adverse effects is high, your doctor may determine the best possible course of treatment. It is recommended to take appropriate precautionary measures while taking them together.

  Ethinyl Estradiol

  Report the use of any hormonal contraceptive, irrespective of the form in which it is consumed, to the doctor. Use of these medicines together are not recommended as the risk of adverse effects are significantly high. Report any incidence of chest pain, breathing difficulties, the presence of blood in cough or urine to the doctor on priority.

  Tretinoin

  Report the use of either of the medicine to the doctor. Using these medicines together may increase the risks of serious adverse effects especially in the initial stages of treatment. Seek immediate help if you experience symptoms of internal blood clots like shortness of breast, chest pain, presence of blood in urine or cough, swelling of arms and legs.

  Factor IX complex

  Report the use of any medicine used for improving the clot formation process to the doctor. Your doctor may prescribe an alternate medication or schedule the dosing in such a way that there is sufficient time gap between the consumption of these medicines.

  Chlorpromazine

  Chlorpromazine if taken along with Tranexamic Acid (may increase cerebral vasospasm and ischemia).

• Interaction with Food

  Information not available.

• Interaction with Disease

  Dosage modification required in patients with renal impairment; ophthalmic exam before and during therapy required if patient is treated beyond several days; caution in patients with cardiovascular, renal, or cerebrovascular disease; when used for subarachnoid hemorrhage, ischemic complications may occur.

• Ques : What is Tranexamic Acid?

  Ans : Tranexamic Acid is a medication which has Tranexamic Acid as an active factor present in it. This medicine performs its action by preventing bleeding. This tablet is used to treat conditions such as heavy menstrual bleeding, Severe loss of blood, Blood clotting problems, and Swelling in various body parts.

• Ques : What is the use of Tranexamic Acid?

  Ans : Tranexamic Acid is a medication, which is used for the treatment and prevention from conditions such as Heavy menstrual bleeding and Severe loss of blood.

• Ques : What are the side effects of Tranexamic Acid?

  Ans : Side effects of Tranexamic Acid are Fainting, Unusual pain or swelling in arms or legs, Nausea, Sudden breathlessness, Coughing up of blood, Loose motion, Vomiting, Allergic skin reaction, Pain or feeling of heaviness in the chest, Diarrhea, Blurred vision, Low blood pressure, and Blood vessel obstruction by blood clots.

• Ques : Is Tranexamic Acid an over the counter product?

  Ans : No, Tranexamic Acid is not an over the counter product. it is available as a prescription medicine only.

• Ques : How long do I need to use Tranexamic Acid before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 6 hours to 1 day. But the same duration is not mandatory for everyone and so, it is not a standard time period for this medication's action. Please consult your doctor, for the time period you need to use this medication.

• Ques : At what frequency do I need to use Tranexamic Acid?

  Ans : This medication is generally used once or twice a day but it is not the standard frequency, for using this medication. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Tranexamic Acid empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. The salts involved in this medication react properly if it is taken with the food. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Tranexamic Acid?

  Ans : This medication contains salts which are suitable to store only at room temperature. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, for avoiding its inadequate effect.

• Ques : Can Tranexamic Acid cause pulmonary embolism?

  Ans : The medication promotes blood clotting. It is not known to facilitate a blood clot to travel to the lungs (pulmonary embolism). Pulmonary embolism is not a common side effect in patients taking Trenaxa. However, it may occur in overdosing patients with long bedrest or prone individuals.

• Ques : Can I take Tranexamic Acid for more than 5 days?

  Ans : The dose and duration of Tranexamic Acid depends on the type of disease for which it is prescribed. For heavy bleeding during monthly menstruation, it is usually prescribed for up to 5 days.

• Ques : Does Tranexamic Acid affect fertility?

  Ans : No, the medication is not known to have any effect on fertility. It is usually prescribed for heavy menstrual bleeding. Currently, there exists no evidence that suggests interference of this medicine with ovulation (release of eggs from the ovaries).

• Ques : Can Tranexamic Acid be taken for nose bleeding?

  Ans : Yes, the medication can be consumed for nose bleeding as well.

• Tranexamic acid- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/tranexamic%20acid

• TRANEXAMIC ACID injection- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d732fca-8157-49f9-9f08-acf9afb75aa2

• Tranexamic Acid 500mg/5ml Solution for Injection- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 24 Nov 2021]. Available from:

  https://www.medicines.org.uk/emc/product/3374/smpc