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Overview

Zydotum 1000 Mg/500 Mg Injection

Manufacturer :  Venus Remedies Ltd
Medicine Composition :  Ceftazidime, Sulbactam
Prescription vs OTC : Prescription by Doctor required

About Zydotum 1000 Mg/500 Mg Injection

A cephalosporin antibiotic, Zydotum 1000 Mg/500 Mg Injection is used to treat joint infections, meningitis, urinary tract infections, pneumonia, sepsis and malignant otitis externa. It classifies as a semi-synthetic, broad-spectrum antibiotic and acts especially against gram-negative infections. Administration of this medicine into the body is done by injecting it into a vein or a muscle.

Intake of Zydotum 1000 Mg/500 Mg Injection should be avoided if –

  • You have allergy from ceftazidime or other cephalosporin class of antibiotics.
  • You are taking chloramphenicol

Zydotum 1000 Mg/500 Mg Injection may interact with a few medical conditions so keeping your doctor informed if you have any of these medical conditions is important:

  • If you are pregnant or planning to soon be pregnant, or breastfeeding. < /li>
  • If you are already taking any medication, dietary supplement or herbal preparation.
  • If you are taking other medicines especially amnigycosides, diuretics, chloramphenicol, or hormonal birth control pills.
  • If you are allergic to food, medicines or other any other substances.
  • If you have had a history of stomach or bowel problems, kidney problems or poor nutrition.

Zydotum 1000 Mg/500 Mg Injection does not have many side effects. However, in rare cases allergic reactions, and gastrointestinal symptoms may occur along with red streaks on the skin and swelling. Your dosage depends on your age, your weight, your medical condition and the type of bacteria causing infection. It also varies for adults and children. It is advised to follow the doctor’s prescription completely to obtain best results.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the uses of Zydotum 1000 Mg/500 Mg Injection

    • Bacterial Meningitis

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord, caused by Streptococcus pneumoniae and Neisseria meningitidis.

    • Bacterial Septicemia

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of septicemia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.

    • Intra-Abdominal Infections

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of intra-abdominal infections caused by Helicobacter pylori, Staphylococci, and Streptococci.

    • Pneumonia

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of pneumonia which is a common type of lung infection caused by Streptococcus pneumoniae, and Haemophilus influenzae.

    • Bone And Joint Infections

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of bone and joint infections like septic arthritis and osteomyelitis caused by Staphylococci and Streptococci species.

    • Pyelonephritis

      Zydotum 1000 Mg/500 Mg Injection is used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the contraindications of Zydotum 1000 Mg/500 Mg Injection ?

    • Allergy

      Avoid if the patient has a known allergy to Zydotum 1000 Mg/500 Mg Injection or any other Beta-lactam antibiotics like penicillins and cephalosporins.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the side effects of Zydotum 1000 Mg/500 Mg Injection ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Key highlights of Zydotum 1000 Mg/500 Mg Injection

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 3 to 6 hours.

    • What is the onset of action?

      The peak effect of this medicine can be observed in 1 hours for an intramuscular injection.

    • Are there any pregnancy warnings?

      Limited data is available on the use of Zydotum 1000 Mg/500 Mg Injection in pregnant women. Use only if clearly needed when benefits overweigh the risk.

    • Is it habit forming?

      No habit forming tendency has been reported.

    • Are there any breast-feeding warnings?

      Small amounts of this medicine is excreted through human breast milk. Use only if clearly needed when benefits overweigh the risk. Monitoring of undesired effects like diarrhea and thrush is necessary.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the substitutes for Zydotum 1000 Mg/500 Mg Injection ?

    Below is the list of medicines, which have the same composition, strength and form as Zydotum 1000 Mg/500 Mg Injection , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Where is the Zydotum 1000 Mg/500 Mg Injection approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    How does this medication work?

    This medication belongs to the class of an antibiotic that provides protection against the enzymes produced by bacteria. It works by rupturing the bacteria’s cell wall and inhibiting the enzymes that are produced by the bacteria.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

      What are the interactions of Zydotum 1000 Mg/500 Mg Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Lab

        Information not available.
      • Interaction with Medicine

        Amikacin

        You may experience nausea or vomiting, increased or decreased urination, sudden weight gain, and fluid retention if these medicines are taken together. This interaction is more likely to occur if you have a kidney disease. Regular kidney function tests are to be performed and appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Ethinyl Estradiol

        The desired effect of contraceptive pills will not be achieved if these medicines are taken together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Cholera Vaccine

        Avoid cholera vaccine if the patient has taken Zydotum 1000 Mg/500 Mg Injection within 14 days before vaccination. Usage of other antibiotics and vaccines should be reported to the doctor.

        Furosemide

        You may experience nausea or vomiting, increased or decreased urination, sudden weight gain, and fluid retention if these medicines are used together. This interaction is more likely to occur in the elderly population with preexisting kidney disease. Regular kidney function tests are to be performed and appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

        Cyclosporine

        You may experience vomiting, diarrhea, dizziness and headache if these medicines are used together. Regular kidney function tests are to be performed and appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
      • Interaction with Disease

        Impaired Kidney Function

        The blood concentration of intravenous Zydotum 1000 Mg/500 Mg Injection may increase in the patients suffering from any kidney disease. Suitable dose adjustments are to be made based on the severity of the condition. Frequent monitoring of kidney function tests is necessary.

        Colitis

        Avoid if you experience severe diarrhea, abdominal pain, and blood in stools after taking Zydotum 1000 Mg/500 Mg Injection. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

        Seizure Disorders

        Use with caution if you have any seizure disorder or a family history of seizures. Appropriate dose adjustments are to be made if you have a kidney disease. Discontinue if seizure is due to Zydotum 1000 Mg/500 Mg Injection. Start with appropriate anticonvulsant medicine if it is clinically indicated.
      • Interaction with Food

        Food

        Information not available.

      References

      • Ceftazidime-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/ceftazidime

      • Ceftazidime-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:

        https://go.drugbank.com/drugs/DB00438

      • CEFTAZIDIME injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=CEFTAZIDIME

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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