Zymar 0.3% Ointment

Zymar 0.3% Ointment is an antibiotic that is used to treat Bacterial infections. It is prescribed for the treatment of the following infections when caused by susceptible bacteria including Acute bacterial exacerbation of chronic bronchitis, acute sinusitis, and community-acquired pneumonia.

It is also helpful in treating uncomplicated urinary tract infections (cystitis), complicated urinary tract infections, pyelonephritis, uncomplicated urethral and cervical gonorrhea and acute, uncomplicated rectal infections in women.

Don’t stop taking the medicine prematurely as it might cause a relapse of the infection. If you have been using other medication, it is advised to inform your doctor before taking it.

This medicine might be taken with or without food. Drink plenty of fluids. Exposure to direct sunlight must be avoided during therapy and for several days following. Do not take antacids within 4 hours before or 2 hours after dosing.

Contact your physician immediately if signs of allergy occur or if signs of tendon inflammation or pain occur. Do not discontinue therapy until your course has been completed. Take a missed dose as soon as possible, unless it is almost time for your next dose.

Use Zymar 0.3% Ointment cautiously during pregnancy. Discuss with your doctor the possibility of any complication cropping up. Steer clear of it if you have had any allergic reaction to quinolone antibiotics in the past.

Potential symptoms of overdose may include CNS excitation, seizures, QT prolongation, and arrhythmias (including torsade de pointes). Patients should be monitored by continuous EKG in the event of an overdose. Management is supportive and symptomatic. Not removed by dialysis.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• Bacterial Infections

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• Allergy

• Tendinitis Or Tendon Rupture

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• Headache

• Dizziness

• Nausea

• Diarrhoea

• Allergic Reaction

• Chills

• Fever

• Back Pain

• Chest Pain

• Abdominal Pain

• Constipation

• Dyspepsia

• Mouth Ulcers

• Vomiting

• Peripheral Edema

• Rash

• Sweating

• Tinnitus

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• How long is the duration of effect?

  This effect of this medicine lasts for a duration of 2 to 3 days.

• What is the onset of action?

  The peak effect of this medicine can be observed within 1 to 2 hours of oral administration.

• Are there any pregnancy warnings?

  Use of this medicine is not recommended for pregnant women. Use only if clearly needed under the supervision of a doctor.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Use of this medicine is not recommended in women who are breastfeeding due to the adverse effect on the development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Monitoring of undesired effects like diarrhea, diaper rash is necessary.

• Is It safe with alcohol?

  It is unsafe to consume alcohol along with this medicine.

• Is it safe to drive while on this medicine?

  This medicine might cause side effects which will affect the alertness of the patient. Thus driving must be avoided while taking this medicine.

• Does this affect kidney function?

  Caution must be taken in patient with kidney disease. As in patients with Creatinine clearance <40 mL/minute (or patients on hemodialysis/CAPD) should receive an initial dose of 400 mg, followed by a subsequent dose of 200 mg every 24 hours. Patients receiving single-dose or 3-day therapy for appropriate indications do not require dosage adjustment.

• Does this affect liver function?

  No dosage adjustment is required in mild-moderate hepatic disease. No data are available in severe hepatic impairment.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• Missed Dose instructions

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

• India

• United States

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

This medication belongs to the class of an antibiotic that works by inhibiting the enzyme DNA gyrase (topoisomerase II) and topoisomerase IV. This prevents bacterial DNA from replicating, transcribing, repairing and replicating, eventually leading to death.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pharmacologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  • Zymar 0.3% Ointment may prolong Q-T interval; avoid use with drugs which prolong Q-T interval (including class Ia and class III antiarrhythmics, erythromycin, cisapride, antipsychotics, and cyclic antidepressants).
  • Metal cations (magnesium, aluminum, iron, and zinc) bind quinolones in the gastrointestinal tract and inhibit absorption (by up to 98%). Antacids, electrolyte supplements, sucralfate, quinapril, and some didanosine formulations should be avoided. Zymar 0.3% Ointment should be administered 4 hours before or 8 hours after these agents.
  • Antineoplastic agents may decrease the absorption of quinolones.
  • Calcium carbonate was not found to alter the absorption of Zymar 0.3% Ointment.
  • Cimetidine, and other H2 antagonists may inhibit renal elimination of quinolones
  • Digoxin levels may be increased in some patients by Zymar 0.3% Ointment; monitor for increased effect/concentrations.
  • Foscarnet has been associated with an increased risk of seizures with some quinolones
  • H2 antagonists and proton pump inhibitors may decrease absorption of some quinolones
  • Loop diuretics: Serum levels of some quinolones are increased by loop diuretic administration. May diminish renal excretion.
  • NSAIDs: The CNS stimulating effect of some quinolones may be enhanced, resulting in neuroexcitation and/or seizures. This effect has not been observed with Zymar 0.3% Ointment.
  • Probenecid: Blocks renal secretion of Zymar 0.3% Ointment, increasing AUC and half-life.
  • Warfarin: The hypoprothrombinemic effect of warfarin is enhanced by some quinolone antibiotics. No significant effect has been demonstrated for Zymar 0.3% Ointment, however, monitoring of the INR during concurrent therapy is recommended by the manufacturer.

• Interaction with Food

  Food

  Information not available.

• Interaction with Disease

  • Use with caution in patients with significant bradycardia or acute myocardial ischemia.
  • May have potential to prolong Q-T interval; should avoid in patients with uncorrected hypokalemia, or concurrent administration of other medications known to prolong the Q-T interval (including class Ia and class III antiarrhythmics, cisapride, erythromycin, antipsychotics, and tricyclic antidepressants).
  • Safety and effectiveness in pediatric patients (<18 years of age) have not been established. Experience in immature animals has resulted in permanent arthropathy.
  • Use with caution in individuals at risk of seizures (CNS disorders or concurrent therapy with medications which may lower seizure threshold). Discontinue in patients who experience significant CNS adverse effects (dizziness, hallucinations, suicidal ideation or actions).
  • Use caution in renal dysfunction (dosage adjustment required) and in severe hepatic insufficiency (no data available).
  • Use caution in patients with diabetes - glucose regulation may be altered.

• Gatifloxacin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/gatifloxacin

• Gatifloxacin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 28 May 2022].Available from:

  https://go.drugbank.com/drugs/DB01044

• GATIFLOXACIN Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=GATIFLOXACIN