When the body cells encounter foreign invasion (bacterial or viral invasion) into the blood the white blood cells release proteins called Antibodies. The white blood cells sometimes recognize Double-Stranded DNA as a foreign invader and release the Antibodies. This is called DS-DNA- Antibody. It is also called as Antinuclear Antibodies or ANA. It causes inflammation to the body part such as Kidney, lung, heart, and skin. This condition is called Lupus. The DS-DNA- Antibody test is essential when the person encounters fatigue, tiredness, weight loss, hair loss, Urine passes out in dark color, Skin sensitivity for light, headache, and fluctuation in mental status.