The SMA test is performed to find any smooth muscle origin tumours. This test is also performed during the ongoing treatment and again, once the treatment for smooth muscle origin tumour is concluded. To conduct this test, the doctor takes a sample of the biopsy tissue and measures the levels of SMA present in it. While it may sound scary for some, in reality, it is a very simple procedure. The biopsy procedure is entirely pain-free and non-risky. This test is also known as IHC Marker SMA Immunohistochemistry Biopsy Test.