Glutathion helps in skin lightening, but Injectable form of glutathion is only approved for the use to treat liver diseases and not for skin lightening because of potential dose related side-effects. 35-40 injections are needed, placed at 2-3 day intervals. Patchy skin may develop over sun-exposed areas after 10-12 injections, which tends to clear after 20-25 injections. The result lasts for almost 1 year and has to be maintained with oral glutathione. A combination therapy of sunscreens and skin lightening creams, oral glutathion, multivitamins and other antioxidants, along with external treatments like chemical peels, mesopeels, electroporation and lasers will help you achieve the best result in minimum time. According to the FDA, the US drug watchdog, side-effects of the injection range from skin rashes, disruption in thyroid function, kidney damage, Stevens-Johnson syndrome and toxic epidermal necrolysis. The last two life-threatening conditions cause fever, severe rash, blisters and skin peeling. Affected people have to be treated in the hyper-sterile burns wards of hospitals.