How cancer causes? What happen in our body when we are suffering from this? And by which organism ,cancer causes?

Question

Cancer is caused by uncontrolled growth of cells in an area of our body. It can be due to loss of function of tumor suppressor genes or due to increased function of oncogenes. There are many cancers and that many causes of cancer. If localised, it may form a lump or swelling. Usually painless. If it has spread then symptoms due to the affected organ can occur. It is not possible to write about all cancers and all it's symptoms. You can read a book called Devita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology if you want all the symptoms and causes. It is considered a bible of oncology (but the treatment is ever changing) I will enumerate a few causes and symptoms of common cancers in non metastatic settings. Please note that most cancers donot have any cause and are asymptotic 1) Oral cavity and laryngeal cancers Symptoms: ulcer, Leukoplakia or erythroplakia rarely pain, neck node swelling, hoarseness of voice Cause: tobacco, alcohol, smoking, HPV, sharp tooth or ill fitting dentures with chronic trauma 2) Breast Cancer Symptoms: lump, nipple discharge especially blood stained, armpit swelling, nipple retraction, skin redness or thickening, skin dimpling Cause: increasing age and female sex are the most important non modifiable risk factors. Others include obesity, increased estrogen exposure due to early menarche, late menopause, no breast feeding, no children, OC pills, HRT, obesity. Familial due to BRCA genes 3) Colon or rectal cancer: Symptoms: bleeding per Rectum, alternating constipation or loose motions, lump in abdomen, intestinal obstruction Causes: Age, low fibre diet, Familial in AFP or HNPCC 4) kidney cancer Symptoms: Pain, lumbar swelling, hematuria Cause: Smoking, familial 5) urinary bladder cancer Symptoms: Hematuria, urinary retention Causes: smoking 6) lung cancer Symptoms: cough, hemoptysis, breathing difficulty, hoarseness of voice Causes: smoking 7) esophageal cancer Symptoms: difficulty in swallowing food, Causes: smoking, smoked fish 8) stomach cancer Symptoms: black stools, hematemesis, lump in abdomen, obstruction with vomiting Causes: smoking, alcohol 9) liver cancer Symptoms: lump in abdomen Causes: hepatitis B infection with cirrhosis, toxins 10) gall bladder cancer Symptoms: asymptotic, lump in abdomen, jaundice Cause: gall stones, cholesterosis 11) prostate cancer Symptoms: urinary retention, hematuria Cause: age, androgens 12) penile cancer Symptoms: ulcer Cause: HPV related 13) ovarian cancer Symptoms: mass in pelvis Cause: familial 14) endometrial cancer Symptoms: post menopausal bleeding or inter menstrual bleeding Cause: hormonal 15) cervical cancer Symptoms: bleeding pv Cause: HPV related 16) pancreatic cancer Symptoms: jaundice, lump in abdomen Cause: smoking 17) bone cancers: Symptoms: swelling, pain, fracture Cause: multifactorial 18) skin cancer Symptoms: ulcer or black lesion Cause UV rays 19) brain tumor Symptoms: neurological deficit, vomiting, visual deficit Causes: multifactorial 20) blood cancer Symptoms: bleeding, infections Cause: genetic, multifactorial I may have missed many. Have put down what came to my mind.

Nikhilesh Borkar · Accepted Answer

Cancer is caused by uncontrolled growth of cells in an area of our body. It can be due to loss of function of tumor suppressor genes or due to increased function of oncogenes. There are many cancers and that many causes of cancer. If localised, it may form a lump or swelling. Usually painless. If it has spread then symptoms due to the affected organ can occur. It is not possible to write about all cancers and all it's symptoms. You can read a book called Devita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology if you want all the symptoms and causes. It is considered a bible of oncology (but the treatment is ever changing) I will enumerate a few causes and symptoms of common cancers in non metastatic settings. Please note that most cancers donot have any cause and are asymptotic 1) Oral cavity and laryngeal cancers Symptoms: ulcer, Leukoplakia or erythroplakia rarely pain, neck node swelling, hoarseness of voice Cause: tobacco, alcohol, smoking, HPV, sharp tooth or ill fitting dentures with chronic trauma 2) Breast Cancer Symptoms: lump, nipple discharge especially blood stained, armpit swelling, nipple retraction, skin redness or thickening, skin dimpling Cause: increasing age and female sex are the most important non modifiable risk factors. Others include obesity, increased estrogen exposure due to early menarche, late menopause, no breast feeding, no children, OC pills, HRT, obesity. Familial due to BRCA genes 3) Colon or rectal cancer: Symptoms: bleeding per Rectum, alternating constipation or loose motions, lump in abdomen, intestinal obstruction Causes: Age, low fibre diet, Familial in AFP or HNPCC 4) kidney cancer Symptoms: Pain, lumbar swelling, hematuria Cause: Smoking, familial 5) urinary bladder cancer Symptoms: Hematuria, urinary retention Causes: smoking 6) lung cancer Symptoms: cough, hemoptysis, breathing difficulty, hoarseness of voice Causes: smoking 7) esophageal cancer Symptoms: difficulty in swallowing food, Causes: smoking, smoked fish 8) stomach cancer Symptoms: black stools, hematemesis, lump in abdomen, obstruction with vomiting Causes: smoking, alcohol 9) liver cancer Symptoms: lump in abdomen Causes: hepatitis B infection with cirrhosis, toxins 10) gall bladder cancer Symptoms: asymptotic, lump in abdomen, jaundice Cause: gall stones, cholesterosis 11) prostate cancer Symptoms: urinary retention, hematuria Cause: age, androgens 12) penile cancer Symptoms: ulcer Cause: HPV related 13) ovarian cancer Symptoms: mass in pelvis Cause: familial 14) endometrial cancer Symptoms: post menopausal bleeding or inter menstrual bleeding Cause: hormonal 15) cervical cancer Symptoms: bleeding pv Cause: HPV related 16) pancreatic cancer Symptoms: jaundice, lump in abdomen Cause: smoking 17) bone cancers: Symptoms: swelling, pain, fracture Cause: multifactorial 18) skin cancer Symptoms: ulcer or black lesion Cause UV rays 19) brain tumor Symptoms: neurological deficit, vomiting, visual deficit Causes: multifactorial 20) blood cancer Symptoms: bleeding, infections Cause: genetic, multifactorial I may have missed many. Have put down what came to my mind.