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Last Updated: May 02, 2022
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Chronic Fatigue and Exhaustion: Possible Causes and Difference

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Dr. Nishi Nath JhaGeneral Physician • 40 Years Exp.MBBS, MD - Medicine
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Chronic fatigue syndrome is more than just being wary. It's a new level of exhaustion that has lasted at least six months and is severe enough to interfere with your typical daily activities, both at home and at work. 

The difference between chronic fatigue and exhaustion is hard to understand, however, certain parameters can help you determine whether you are just exhausted or have CFS - 

  • Rest and sleep appear to be ineffective
  • Physical exercise might make you feel worse the next day
  • You wake up practically every morning feeling as if you haven't gotten enough sleep, and you frequently wake up in the middle of the night for no apparent reason
  • It's possible that you'll have problems concentrating and multitasking
  • You may feel lightheaded and your heart may race when you stand up from a sitting or lying posture. You may feel dreadful after being on your feet for a time and need to rest down flat

Possible Causes 
Chronic fatigue syndrome has no known explanation, although doctors have discovered a number of underlying problems in those who suffer from it.

  • Immune system issues: People with chronic fatigue syndrome have abnormalities in several elements of their immune system, and some research suggests that these abnormalities may be the source of the illness's symptoms. People with chronic fatigue syndrome, unlike HIV/AIDS patients, do not have a damaged immune system.
  • Energy production: People with chronic fatigue syndrome have problems producing enough energy in their cells.
  • Brain abnormalities: Abnormalities can be visible in brain images (such as MRI or CT scans), brain hormone levels, and the electrical system of the brain (brain waves). These anomalies can appear and disappear, and they are not always permanent.
  • Genes: Several studies have found abnormalities in the structure of particular genes. Other studies have discovered inconsistencies in the way some genes are turned on and off inside cells. Some people inherit a genetic sensitivity to the condition, according to investigations of identical and non-identical twins.
  • Infections or other illnesses: Chronic fatigue syndrome is frequently preceded by a sudden infectious-like sickness, however, this is not always the case. Several infectious agents, including the Epstein-Barr virus (a major cause of mononucleosis), Lyme disease bacteria, and Q fever bacteria, have been shown to induce the onset of the condition.
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