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Diseases: some animals carry bacteria and/or viruses which are harmless to them but pathogenic to humans. There is (an unproved to the best of my knowledge) scientific hypothesis, that aids was introduced by sexual encounters between human and apes. Physical damage: in some cases, the human involved might get hurt. One of the more known cases happened about 2 years ago in the uk where a woman had sex with a horse and died when the horse tore her intestinal tract apart.
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