Dear doctor greetings my wife, 64 years is on pd medication since last 5 years. Presently she is on syndopa plus 1-1-1-1, pramipex er1. 5 mg 1-0-0, pacitane 2 mg 1-1-0, amantrel 100 1-1-1 she has slight dyskinesia since last 6 months. She is able to manage her routine work, despite slight swaying. Our neuro prescribed amantrel 100 to address dyskinesia but we do not see any benefit. Request your opinion. Off late she experiences calf muscle sprain just when she is about to take 2nd dosage of syndopa plus. This sprain lasts for 45 minutes to 1.30 hrs after which she feels relieved & happy our neuro prescribed catch free tab - vitamin supplement. Request opinion exercise 30 minutes in the morning and evening is part of other routine. Doctor sir, replacing syndopa plus with syndopa cr 125 mg only for first dose is of any benefit in addressing calf muscle sprain? Awaiting your valuable response