IHC - Synaptophysin Test

HC stains are very useful category of special tests. IHC or immunohistochemistry is used in diagnosis of abnormal cells such as those found in cancerous tumors. It is based on the principle that each type of antibody recognizes and attaches to antigens that fit it exactly. If the cells have specific antigen, they will attract the antibody that fits the antigen. Chemicals are added that make the cells change color only if a certain antibody is present. Synaptophysin is a glycoprotein that is an integral part of the neuroendocrine secretory granule membrane and is recognized by monoclonal antibody in a variety of neuroendocrine tumors. Using IHC, synaptophysin can be demonstrated in a range of neural and neuroendocrine tissues. As a specific maker for these tissues, it can be used to identify tumors arising from them. Synaptophysin is reliable, and hence, is the most commonly used IHC marker for neuronal differentiated tumor. It is performed to confirm neuroendocrine Tumors and also during the treatment and after the treatment of Neuroendocrine Tumors. It is also known as IHC Marker Synaptophysin Immunohistochemistry Biopsy Tissue.

No special preparations are required. However information about previous medications or any underlying medical conditions or allergies before undergoing Synaptophysin IHC Biopsy Tissue should be disclosed. The doctor considers the factors like the kind of tumor suspected, signs, symptoms, age, medical conditions and result of earlier medical tests to determine the kind of diagnostic test that should be done. . Specific instructions will be given accordingly.

By using IHC the source of the cancer cells can also be deducted. Other tests can suggest that a tumor is present, but only a biopsy can make a definite diagnosis. Some IHC stains can help recognize specific substances in cancer cells that influence a patient’s prognosis and/or whether they are likely to benefit from certain drugs. The result for Synaptophysin IHC Biopsy Tissue for Synaptophysin is A positive staining is seen in case of detection of Neuroendocrine Tumors for Unisex gender and for all age groups.

Synaptophysin IHC biopsy tissue is done using IHC method on a biopsy tissue sample. Biopsy is a procedure of removing a piece of tissue or a sample of cells from a person’s body so that it can be analyzed.