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Hello, I have been diagnosed with LABC -- locally advanced breast cancer (Stage 3C) I would like to know more about the tumour markers CA 15-3 ,CA 27-29 and CEA. I would like to know how many breast cancer cells must exist in the body to elicit a positive response --- 1, 5, 20 or a few hundred. If a single breast cancer cell can elicit a positive tumour marker response then these tests can be used after treatment (chemo, surgery and radiation) to see if any cancer cell has survived. Alternatively after treatment I can get my blood tested every two weeks to see if there is any recurrence. In other words I am looking for information about the SENSITIVITY of these tumour marker tests. Waiting for your reply (Female, 40 years)
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Unfortunately the tumour markers for breast cancer are not at all sensitive or specific. As such they are not used for surveillance or diagnosis or follow up. For diagnosis a combination of clinical breast examination, mammogram (xray and/or usg) and biopsy gives almost 100% diagnosis. After completion of treatment, the follow up is with clinical examination and a mammogram.
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