My 7 years old labrador has been dull for the last 15 days, appetite normal, had blood in stool 2 days ago, blood test revealed low BUN at 7.24, elevated sgot at 69.63, elevated alkaline phosphatase at 107. Xrays and ultrasound revealed enlarged spleen. Stool test showed presence of pus cells, blood. He has had thyroid issue for the last 3 years for which we give him thyronorm 100 daily. What disease could he possibly have?

Dr. Kaustubh GarudVeterinarian10yrs exp

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How are his platelets? bun could be low because of long term fasting or because of reduced generation by liver. In latter case, get him blood ammonia levels checked. Its a test to done immediately (within 1 hr latest) after the blood is drawn. I would not consider sgpo and alkaline phosphatase elevated at those levels, however laboratory standards are different everywhere. Discuss following things with your vet. 1) contribution of ammonia levels in dullness. 2) possible underdosing of thyroid hormone supplements. For which, you can sent his blood 4-6 hrs post tablet, to see if 100mcg dose is helping you to achieve normal blood levels. If not, you may need to increase dosing and make it twice daily, after discussing with your vet. Hope this is helpful. 

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