My brother have multiloculated pleural effusion and fever, loss of appetite taking att 11sep (akurit4). Patient conditions not improving since 28 Oct, LFT was done sgpt 745and sgot422 then AKURIT4 withdraw and give new regimen levofloxacin, ethambutol, streptomycin and amoxyclav till 17 nov, again LFT was done, LFT finding is normal. THEN again H/R/Z/E/S/Levofloxacin is again, LFT is done on2 dec sgpt 145and sgot72. During this period fever Pleural effusion, loss of appetite and weakness continue.