Want to talk regarding Kawasaki disease and prognosis. Role of iv ig. Please suggest.

Question

Kawasaki disease is a multisystem disease which is diagnosed on the basis of many clinical (high fever, rashes, asymmetrical cervical lymphadenopathy, nonpurulant conjuctivitis, strawberry tongue, peeling aseptic pyourea, leykocytosis, high CRP / ESR,) and lab parameters. This needs to be differentiated from bacterial and viral exanthemes. KD may be classified as typical and atypical KD. Scarlet fever is closest DD. All issues can be resolved but coronary artery changes. CA gets involved in 25 to 40 % cases. Echo diagnosis of changes can be seen after 10 days of fever. An early diagnosis is important. Usually IVIG therapy between 5 to 10 day of fever, may prevent coronary artery aneurysm / stenosis in upto 95 to 98% cases. Most accepted theory about the pathogenesis is AUTOIMMUNE process.

Smita Mishra · Accepted Answer

Kawasaki disease is a multisystem disease which is diagnosed on the basis of many clinical (high fever, rashes, asymmetrical cervical lymphadenopathy, nonpurulant conjuctivitis, strawberry tongue, peeling aseptic pyourea, leykocytosis, high CRP / ESR,) and lab parameters. This needs to be differentiated from bacterial and viral exanthemes. KD may be classified as typical and atypical KD. Scarlet fever is closest DD. All issues can be resolved but coronary artery changes. CA gets involved in 25 to 40 % cases. Echo diagnosis of changes can be seen after 10 days of fever. An early diagnosis is important. Usually IVIG therapy between 5 to 10 day of fever, may prevent coronary artery aneurysm / stenosis in upto 95 to 98% cases. Most accepted theory about the pathogenesis is AUTOIMMUNE process.