My daughter is 18 years old thalassemia child. She has been detected combs Direct positive. Kindly advise the treatmen. Thank you.

Question

As she is thalassemic, so I think, she is receiving regular blood transfusion. The direct coombs test may become positive in many situations and treatment is completely different for those. First the test may give false positive report, if done within 3 weeks of last transfusion. If it is true positive, then we need to do indirect coombs test with specific card (3 card or 11 card) to know whether it is auto immune or allo immune in nature. For details evaluation you need to contact with immuno hematologist with very good transfusion medicine lab facility. You can contact in paid online consultation for further evaluation and management protocol. Thanks.

Dibyendu De · Accepted Answer

As she is thalassemic, so I think, she is receiving regular blood transfusion. The direct coombs test may become positive in many situations and treatment is completely different for those. First the test may give false positive report, if done within 3 weeks of last transfusion. If it is true positive, then we need to do indirect coombs test with specific card (3 card or 11 card) to know whether it is auto immune or allo immune in nature. For details evaluation you need to contact with immuno hematologist with very good transfusion medicine lab facility. You can contact in paid online consultation for further evaluation and management protocol. Thanks.