Hello, my sister has primary hypogonadism due to turner syndrome with hishimoto's thyroiditis. Doctors suggested a course of estrogen tablet called evadiol with another tablet called deviry and thyroxine tablets for thyroid problem. We continued the thyroid tablets with multiple testing of THS and increased dose but ditched the estrogen course about after one year. And its been 6 moths since then. Now she is facing some sort of problem, she can not explain correctly what is the problem exactly but she is saying that she is feeling weak and disturbed. What can be the reason behind it? And please help me with this. What should we do? Should we continue with the old course? Her current age is 20. She was diagnosed with all these in 18. Please help.