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If both partners are clean and they do not have any sexual transmitted diseases means they can do anal sex without wearing a condom.
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Hello- no, they can't. The anus contains several harmful bacterial infections apart from std (that you are discussing). So its best not to do it without protection. Secondly, the anus is not lubricated like the vagina so it may harm you or your partner and cause frictional injury too during the act. Condom and external lubrication can provide ease and safety both at the same time.
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